Anxiety, Depression, and Quality of Life in Parkinson’s Disease

Quelhas, Rosa; Costa, Manuela

doi:10.1176/jnp.2009.21.4.413

Cited by 70 publications

(37 citation statements)

References 23 publications

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“…A recent systematic review concluded that depression, disease severity and disability negatively influence the patient-reported impact of PD and thus determined depression to be an important predictor of QOL (36). Similar results have been reported for anxiety (3)(4)(5); however, with insufficient supporting data (37). Many studies have heretofore focused on the impact of depression and motor disability on poor life quality while neglecting to examine the role of anxiety.…”

Section: Discussionmentioning

confidence: 71%

“…Quelhas et al (4) also showed anxiety to be the strongest predictor of QOL. Further research is necessary to address this issue since these studies dealt with a small number of patients, used a generic measure for QOL (the Short Form-36 Health Survey questionnaire) and excluded specific aspects of PD management such as iatrogenic symptoms (4).…”

Section: Discussionmentioning

confidence: 99%

“…However, it is unclear whether these two symptoms share common pathophysiological mechanisms (1,2). The effects of depression on quality of life (QOL) in patients with PD have been intensively studied; however, less attention has been paid to anxiety (3)(4)(5), even though anxiety can contribute to a patient's discomfort. Although earlier studies describing the QOL in patients with PD found either depression or disease severity to be the most frequently associated with the QOL (6)(7)(8), the majority of these studies did not include both anxiety and depression in their models.…”

Section: Introductionmentioning

confidence: 99%

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Anxiety and Depression in Patients with Parkinson's Disease

et al. 2013

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Objective To investigate the prevalence and clinical correlates of anxiety and depression in patients with Parkinson's disease (PD) and to examine the relationship between anxiety and depression and the quality of life (QOL). Methods One hundred and seventeen patients with PD completed the State-Trait Anxiety Inventory (STAI), the Beck Depression Inventory Second Edition (BDI-II), Starkstein's Apathy Scale (AS) and QOL battery. Hoehn and Yahr (HY) staging, the Unified Parkinson's Disease Rating Scale (UPDRS) and the Mini-Mental State Examination (MMSE) were administered on the same day. Results Anxiety (STAI score ! 41 for men or ! 42 for women) was diagnosed in 55% of the patients and depression (BDI-II score ! 14) was diagnosed in 56% of the patients. Anxiety coexisted with depression in 41% of the patients, while depression without anxiety was observed in 15% of the patients and anxiety without depression was observed in 14% of the patients. The STAI score was found to be significantly correlated with the UPDRS (I, IVC) and AS scores, whereas the BDI-II score was found to correlate with the HY stage and the UPDRS (I, III, IVB, C) and AS scores. Both the STAI and BDI-II scores were found to negatively correlate with QOL. A multivariate analysis revealed that depression and anxiety are similarly associated with the PD specific QOL (PDQ-39), while motor severity, as judged by the HY stage and UPDRS III score, is not. Conclusion These findings indicate that recognizing anxiety and depression in patients with PD is important, since both conditions are commonly observed in patients with PD and are similarly associated with the QOL, independent of motor severity.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anxiety and Depression in Patients with Parkinson's Disease

et al. 2013

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“…Previous studies have found a strong relationship between cognitive and affective symptomatology in PD and decreased QoL [5,52,53,54], as well as impairment of everyday functioning [7,55]. Therefore, identifying neuropsychological impairments in EOPD should be important to clinicians to provide a more comprehensive treatment that includes multidisciplinary interventions.…”

Section: Discussionmentioning

confidence: 99%

Mild Cognitive Impairment in Patients with Early-Onset Parkinson's Disease

Seubert-Ravelo

Yáñez-Téllez²,

Salgado–Ceballos³

et al. 2016

Dement Geriatr Cogn Disord

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Background/Aims: Few studies have described mild cognitive impairment (MCI) and cognitive characteristics in early-onset Parkinson's disease (EOPD). This study describes attention/working memory, language, memory, visuospatial abilities, executive function, and frequency of MCI and dementia in EOPD. Methods: Eighty-one EOPD patients were administered neuropsychological tests and the Beck Depression Inventory. Scores were compared with age/education-appropriate norms and were correlated to years of disease progression and severity of motor symptoms. The frequency of MCI and dementia was determined by the Movement Disorder Society criteria. Results: Thirty-one percent of patients met the MCI criteria, but none had dementia. Commonly affected domains were memory, visuospatial, and executive function. Cognitive dysfunction was not explained by depression or severity of motor symptoms. Conclusion: One third of EOPD patients presented with MCI, which was not associated with the same risk factors as reported in late-onset Parkinson's disease. MCI could have a different prognostic value in EOPD.

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“…12 Many studies report comparable effects of depression and anxiety on quality of life, but at least one suggested that anxiety may be the strongest predictor of quality of life in PD. 13 In addition, psychiatric symptoms contribute significantly to level of caregiver burden and distress. [14][15][16] One study found that the greatest predictor of caregiver-endorsed depressive symptomology on the Geriatric Depression Scale (GDS) was the cared-for patient's GDS score, 17 suggesting that depressive symptoms in PD patients predict depressive symptoms in their spouses, arguably leading to overall greater health-care burden and cost.…”

Section: Impactmentioning

confidence: 99%