Anxiety, Depression and Quality of Life in Patients with Irritable Bowel Syndrome

Cho, Hyun Sun; Park, Jae Myung; Lim, Chul-Hee; Cho, Yu Kyung; Lee, In Seok; Kim, Sang Woo; Choi, Myung-Gyu; Chung, In Sik; Chung, Yun Kyung

doi:10.5009/gnl.2011.5.1.29

Cited by 139 publications

(133 citation statements)

References 43 publications

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“…In this study, the prevalence of CES-D 16 depression among individuals with IBS was 32.8%. The prevalence of CES-D 16 depression in our study was within the range of previous results (16-39%) (2,9,23,24). After adjustment for confounders, “active solution” coping behaviors were significantly associated with somatic symptoms.…”

Section: Discussionsupporting

confidence: 89%

Depressive Symptoms and Coping Behaviors among Individuals with Irritable Bowel Syndrome in Japan

et al. 2017

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Objective Irritable bowel syndrome (IBS) is associated with a high prevalence of psychological disorders. Coping, which is used to manage stressful events, can have adaptive or maladaptive effects on a patient's health status. However, these coping behaviors have not been well studied in individuals with IBS. The association between the use of coping behaviors and the reported levels of depressive symptoms was examined in individuals with IBS. Methods Among 993 volunteers (382 men and 611 women) who participated in the Iwaki Health Promotion Project in 2013, we included 58 subjects who fulfilled the Rome III criteria for IBS in our analysis. Coping behaviors were assessed using the Brief Scale for Coping Profile (BSCP). The Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess the four dimensions of depressive symptoms (depressed affect, somatic symptoms, interpersonal problems, and lack of positive affect) and the prevalence of probable depression using a cut-off score of 16. Results Among the 58 subjects with IBS, 22 (36.1%) exhibited probable depression. After adjustment for confounders, “active solution” was found to be significantly associated with somatic symptoms. Under the same conditions, “avoidance and suppression” was significantly associated with the CES-D total score, depressed affect, somatic symptoms, and (lack of) positive affect. There were no other significant relationships between depressive symptoms and the BSCP sub-scale scores. Conclusion These findings indicate that coping behaviors may influence the experience of depressive symptoms among individuals with IBS. Psychological therapy may reduce depressive symptoms as well as the severity of IBS symptoms. Additional studies are needed to examine the relationships between coping behaviors and depressive symptoms using a longitudinal study design.

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Section: Discussionsupporting

confidence: 89%

Depressive Symptoms and Coping Behaviors among Individuals with Irritable Bowel Syndrome in Japan

et al. 2017

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“…Regardless of etiology, IBS patients have heightened anxiety and depression scores, compared to healthy controls [11][12][13][14], as well as a significantly lower quality of life [11,15,16]. Lack of reliable diagnostic tests for IBS, combined with the patients' anxiety and stress induced by symptom variability, could lead to increased health care seeking [17,18], consequently exposing patients to numerous invasive, unpleasant and often unnecessary tests.…”

Section: Introduction/backgroundmentioning

confidence: 99%

Fecal Calprotectin and serum chromogranin A as potential biomarkers of irritable bowel syndrome symptom severity

et al. 2015

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“…[10][11][12][13][15][16][17][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] The baseline characteristics of included studies are shown in Table 1 22,29 Sphere score in 1 study, 24 and the Beck Anxiety Inventory (BAI) in 1 study. 30 …”

Section: Baseline Characteristics Of Included Studiesmentioning

confidence: 99%

“…A total of six studies were included. 15,17,18,37,38,65 In those studies, healthy-control groups were used for multiple comparisons with the three IBS-subtypes; we divided the healthy-control group into three groups for meta-analysis of three IBS-subtypes alongside healthy controls. Depression levels were significantly higher in IBS-C (SMD = 0.83; 95% CI, 0.61-1.06; I 2 = 0%; P < 0.001), IBS-D (SMD = 0.73; 95% CI, 0.51-0.96; I 2 = 0%; P < 0.001), and IBS with mixed bowel habits (SMD = 0.62; 95% CI, 0.39-0.84; I 2 = 0%; P < 0.001) (Fig.…”

Section: Depression and Anxiety In Irritable Bowel Syndrome-subtypementioning

confidence: 99%

The Increased Level of Depression and Anxiety in Irritable Bowel Syndrome Patients Compared with Healthy Controls: Systematic Review and Meta-analysis

Lee

Doo

Choi

et al. 2017

J Neurogastroenterol Motil

177

151

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Background/AimsIrritable bowel syndrome (IBS) patients commonly experience psychiatric disorders, such as depression and anxiety. This meta-analysis sought to compare depression and anxiety levels between IBS patients and healthy controls. MethodsWe searched major electronic databases (PubMed, EMBASE, MEDLINE, and Cochrane library) to find comparative studies on IBS patients and healthy controls. The primary outcome was a standardized mean difference (SMD) of anxiety and depression levels; subgroup analyses were conducted according to IBS-subtypes. ResultsIn total, 2293 IBS patients and 4951 healthy controls from 27 studies were included. In random effect analysis, depression and anxiety levels were significantly higher in IBS patients (pooled SMD = 0.76; 95% CI, 0.62-0.90; P < 0.001; I 2 = 77.2% and pooled SMD = 0.84; 95% CI, 0.67-1.01; P < 0.001; I 2 = 85.6%, respectively). Both analyses' funnel plots showed symmetry. In meta-regression analysis, heterogeneity was due to the studied region and questionnaire type for both depression and anxiety. In sub-group analyses of IBS-subtype, the pooled SMDs of depression and anxiety levels (IBS with predominant constipation: 0.83 and 0.81, IBS with predominant diarrhea: 0.73 and 0.65, and IBS with mixed bowel habits: 0.62 and 0.75; P < 0.001, respectively) were significantly higher in all IBS-subtypes. ConclusionsThe present meta-analysis showed depression and anxiety levels to be higher in IBS patients than in healthy controls, regardless of IBSsubtype. However, the gender effect on psychological factors among IBS patients could not be determined and should be evaluated in prospective studies.

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Anxiety, Depression and Quality of Life in Patients with Irritable Bowel Syndrome

Abstract: Anxiety and depression were frequently observed in Korean IBS patients and were related to the severity of their symptoms and the impairment of the patient's QOL. Our data suggest that assessing anxiety and depression is important when evaluating IBS patients.

Cited by 139 publications

References 43 publications

Depressive Symptoms and Coping Behaviors among Individuals with Irritable Bowel Syndrome in Japan

Depressive Symptoms and Coping Behaviors among Individuals with Irritable Bowel Syndrome in Japan

Fecal Calprotectin and serum chromogranin A as potential biomarkers of irritable bowel syndrome symptom severity

The Increased Level of Depression and Anxiety in Irritable Bowel Syndrome Patients Compared with Healthy Controls: Systematic Review and Meta-analysis

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