Anxiety, depression, impulsivity and substance misuse in violent and non-violent adolescent boys in detention in China

Zhou, Jiansong; Witt, Katrina; Zhang, Yingdong; Chen, Chen; Qiu, Changjian; Cao, Liping; Wang, Xiaoping

doi:10.1016/j.psychres.2014.01.024

Cited by 38 publications

(23 citation statements)

References 54 publications

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“…Pathological impulsivity is a core symptom of ASPD (Swann et al, 2009) that relates to the aversive behaviors and comorbidities associated with the disorder, including violent offending (Zhou et al, 2014) and alcohol dependence (Rubio et al, 2008). There are very few molecular imaging studies of ASPD and, to the best of our knowledge, no abnormalities identified from postmortem investigations in clinically diagnosed individuals with the condition, although brain phenotypes such as low orbitofrontal cortex (OFC) 5-HT 2A receptor binding in impulsive males with ASPD (Meyer et al, 2008;Rylands et al, 2012) and increased amphetamine-induced nucleus accumbens dopamine release in humans with high impulsive-antisocial psychopathic traits (Buckholtz et al, 2010) have been reported.…”

Section: Introductionmentioning

confidence: 99%

Lower Monoamine Oxidase-A Total Distribution Volume in Impulsive and Violent Male Offenders with Antisocial Personality Disorder and High Psychopathic Traits: An [11C] Harmine Positron Emission Tomography Study

Kolla

Matthews

Wilson

et al. 2015

Neuropsychopharmacol

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Antisocial personality disorder (ASPD) often presents with highly impulsive, violent behavior, and pathological changes in the orbitofrontal cortex (OFC) and ventral striatum (VS) are implicated. Several compelling reasons support a relationship between low monoamine oxidase-A (MAO-A), an enzyme that regulates neurotransmitters, and ASPD. These include MAO-A knockout models in rodents evidencing impulsive aggression and positron emission tomography (PET) studies of healthy subjects reporting associations between low brain MAO-A levels and greater impulsivity or aggression. However, a fundamental gap in the literature is that it is unknown whether brain MAO-A levels are low in more severe, clinical disorders of impulsivity, such as ASPD. To address this issue, we applied [(11)C] harmine PET to measure MAO-A total distribution volume (MAO-A VT), an index of MAO-A density, in 18 male ASPD participants and 18 age- and sex-matched controls. OFC and VS MAO-A VT were lower in ASPD compared with controls (multivariate analysis of variance (MANOVA): F2,33=6.8, P=0.003; OFC and VS MAO-A VT each lower by 19%). Similar effects were observed in other brain regions: prefrontal cortex, anterior cingulate cortex, dorsal putamen, thalamus, hippocampus, and midbrain (MANOVA: F7,28=2.7, P=0.029). In ASPD, VS MAO-A VT was consistently negatively correlated with self-report and behavioral measures of impulsivity (r=-0.50 to -0.52, all P-values<0.05). This study is the first to demonstrate lower brain MAO-A levels in ASPD. Our results support an important extension of preclinical models of impulsive aggression into a human disorder marked by pathological aggression and impulsivity.

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Section: Introductionmentioning

confidence: 99%

Lower Monoamine Oxidase-A Total Distribution Volume in Impulsive and Violent Male Offenders with Antisocial Personality Disorder and High Psychopathic Traits: An [11C] Harmine Positron Emission Tomography Study

Kolla

Matthews

Wilson

et al. 2015

Neuropsychopharmacol

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“…More importantly, the K-SADS-PL (the Schedule for Affective Disorder and Schizophrenia for School-Age Children-Present and Lifetime) 15–17 , a semi-structured psychiatric interview based on DSM-IV criteria (the Diagnostic and Statistical Manual of Mental Disorders) 1 , was adopted in this study to exclude the additional psychiatric disorders by a professional interview psychiatrist. Consequently, all CD subjects met the K-SADS-PL criteria for CD and also the following criteria 18–21 : (1) satisfying the DSM-V criteria for CD; (2) no histories of neurological disorders; (3) no histories of other psychiatric disorders (e.g., attention deficit/hyperactivity disorder (ADHD), anxiety and depression disorders, affective disorders, obsessive-compulsive disorder, oppositional defiant disorder (ODD), mental retardation, alcohol- and drug-use disorder, and substance use disorder); (4) right handed; and (5) normal and corrected-to-normal vision. The subjects used for the present study were the same with the screened ones in the previous work 18 .…”

Section: Methodsmentioning

confidence: 99%

Investigation of the Changes in the Power Distribution in Resting-State Brain Networks Associated with Pure Conduct Disorder

Zhang

Zhou

et al. 2017

Sci Rep

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Conduct disorder (CD) is a psychiatric disorder in children and adolescence. To investigate changes in the power distribution in brain networks between CD and typically developing (TD) groups, resting-state functional magnetic resonance imaging (rsfMRI) data of thirty-six subjects were first recorded, and then the data were preprocessed using DPARSF and SPM8. Meanwhile, the power of the blood oxygenation level-dependent (BOLD) signals of ninety brain regions was acquired using the integral of the Welch power spectral density (PSD). Additionally, the powers of the brain regions that reached significance (p < 0.05) were extracted using the bootstrap statistics, in which the standardized z-scores of the powers were used as a reference. The results of the analysis of the changes in power exhibited that there were significant power differences in some pairs of brain regions between the CD and TD groups, indicating a change in the power distribution. In addition, the results also suggest that the total power consumption of brain networks in CD patients is less than that observed in the TD group. Consequently, the study provided a paradigm for establishing quantifiable indicators via the power spectrum approach for the comparison and analysis of the BOLD signal power between CD patients and healthy controls.

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“…Pesquisa com adolescentes infratores chineses, também com idade média de 16 anos, recrutados em centros de detenção localizados em três diferentes províncias do país, verificou que entre os transtornos psiquiátricos prevalentes estavam os de conduta, os por uso de substâncias e o transtorno de déficit de atenção e hiperatividade (Zhou et al, 2014).…”

Section: O Uso De Substâncias Psicoativas Em Meio a Adolescentes Infrunclassified

“…Primeiramente, em relação à prevalência de adolescentes que referiram fazer uso de maconha, a proporção encontrada no presente estudo se assemelhou àquelas encontradas em muitos estudos desenvolvidos, em diversas partes do mundo, nos quais também se verifica porcentagens, variando entre 70% e 87%, em amostras de adolescentes infratores (Copur et al, 2005;Kohler, et al, 2009;Robertson, et al, 2004;Sedlak & McPherson, 2010;Teplin, et al, 2002;Zhou et al, 2014). Os resultados vão ao encontro dos estudos nacionais com adolescentes em conflito com a lei.…”

Section: Procedimentos De Análise Dos Dadosunclassified

“…Conforme o mencionado, o álcool apareceu como segunda substância mais utilizada entre os participantes da presente pesquisa (57,7%). Diversos estudos internacionais e nacionais apontam na mesma direção, indicando proporções elevadas de adolescentes infratores que referem usar álcool (Copur et al, 2005;Kohler, et al, 2009;Robertson, et al, 2004;Sedlak & McPherson, 2010;Teplin, et al, 2002;Zhou et al, 2014), sendo que em alguns dos trabalhos a prevalência do uso de álcool se sobressai até mesmo ao de maconha.…”

Section: Procedimentos De Análise Dos Dadosunclassified

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Adolescentes em conflito com a Lei: relações entre o comportamento delituoso e o de uso de substâncias psicoativas

Bono¹

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Most young emits some antisocial behaviors; a minority, however, will manifest these behavior often, which may pose a risk to the persistence and aggravation of these, over time. Among the antisocial behaviors are criminal and use of substances behaviors. Studies show that substance use among the young offenders is higher than in the general population of adolescents and happens more worryingly. The purpose of this study was characterizing the offending behavior and the substance use, using data from a sample of 120 juvenile offenders. The adolescents were recruited in the context of initial custody, after the police report. They were invited to participate and their parents/guardians were contacted and asked to authorize their participation in the research, following the ethical standards. To collect data, we used: Sociodemographic Interview; Self-Report Delinquency Interview; DUSI-R (Drug Use Screening Inventory). Descriptive analyzes and subsequently Clusters tests were performed. To observe the internal and external statistical differences between subgroups, we used appropriate tests. Results revealed that teenagers have committed other offenses beyond that for which they were held in custody, most nonviolent. With regard to psychoactive substances, 84% reported having used and 70% use in the last month. Cannabis and alcohol was the substances with a higher prevalence of lifetime use and use in the month. The most adolescents who reported substance use in the past month, has quite frequent use of cannabis (more than 20 times). The pattern of substance use on average was: initial use to 12 years of age and simultaneous use of more than one distinct substance. The frequency use in the last month among these was substantially high, with everyday use. However, most adolescents have usage pattern considered abstinent and experimental and the major problems related to substance use was the relationship with "peers" and "school". The criminal engagement, taking into account the age of initiation of offenses, number of different offenses committed and overall frequency of crimes committed in life, contributed to the establishment of three clusters. The clusters was significantly diferentes in the substance use patterns, indicating a positive relationship between greater infraction engagement and standard more problematic use. The clusters also differed externally in the marjority of the DUSI-R constructs-eight of the ten constructs investigated by the instrument showed statistical differences. Different drug-crime relationships were noted; however, we can not be established with accuracy the direction of these relationship. Anyway, it was noted in this study the differences among the offenders in the two focused variables, which require some reflection on the need for for specialized and differentiated interventions.

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Anxiety, depression, impulsivity and substance misuse in violent and non-violent adolescent boys in detention in China

Cited by 38 publications

References 54 publications

Lower Monoamine Oxidase-A Total Distribution Volume in Impulsive and Violent Male Offenders with Antisocial Personality Disorder and High Psychopathic Traits: An [11C] Harmine Positron Emission Tomography Study

Lower Monoamine Oxidase-A Total Distribution Volume in Impulsive and Violent Male Offenders with Antisocial Personality Disorder and High Psychopathic Traits: An [11C] Harmine Positron Emission Tomography Study

Investigation of the Changes in the Power Distribution in Resting-State Brain Networks Associated with Pure Conduct Disorder

Adolescentes em conflito com a Lei: relações entre o comportamento delituoso e o de uso de substâncias psicoativas

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