Anxiety, Depressive, and Posttraumatic Stress Disorders Among Mothers of Pediatric Survivors of Hematopoietic Stem Cell Transplantation

Manne, Sharon L.; DuHamel, Katherine N.; Ostroff, Jamie S.; Parsons, Susan K.; Martini, Daniela; Williams, Sharon E.; Mee, Laura; Sexson, Sandra B.; Austin, Jane E.; Difede, Joanne; Rini, Christine; Redd, William H.

doi:10.1542/peds.113.6.1700

Cited by 88 publications

(97 citation statements)

References 55 publications

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“…Maternal age (younger) has been previously identified as a risk factor for psychopathology in this population. 16 Young mothers who care for very ill children may have limited personal and external resources to address the multiple stressors related to their child caring role, which may increase their risk for psychological distress. In contrasting, older fathers who, before the child's illness, may have been less involved in childcare than mothers 3 may cope differently than mothers when taking child-caring responsibilities.…”

Section: Discussionmentioning

confidence: 99%

“…15 A small percentage of mothers have been diagnosed with major depression, posttraumatic stress and generalized anxiety 18 months post SCT, with younger mothers presenting the highest symptoms at pre-SCT. 16 The longitudinal studies addressing parental distress after SCT are mainly for mothers. [17][18][19][20][21] In summary, the current literature is inconclusive regarding parental gender differences and psychological distress, and related factors after pediatric SCT.…”

Section: Introductionmentioning

confidence: 99%

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Differences in mothers’ and fathers’ psychological distress after pediatric SCT: a longitudinal study

Barrera

Atenafu

Doyle

et al. 2011

Bone Marrow Transplant

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The purpose of this study was to examine longitudinally psychological distress and its correlates in mothers and fathers of children who undergo SCT, up to 2 years post SCT. A total of 111 parents of patients diagnosed mainly with leukemia completed standardized measures of depression and anxiety symptoms as indicators of psychological distress, 85 at 1 year pre-SCT and 81 at 2 years post SCT. Parents' age and gender, child's age, diagnosis, radiation history, behavior and physical health were examined as potential related factors. Linear mixed models for repeated measures with appropriate covariance structure were used in the analysis. Depression and anxiety scores significantly decreased by 2 years for mothers and fathers. Mothers reported significantly more depression symptoms than did fathers, but reported comparable symptoms of anxiety. Pre-SCT depression and anxiety scores, mother's age (younger), child's behavior problems, radiation history and diagnosis of neuroblastoma predicted maternal distress 2 years post SCT; pre-SCT depression and anxiety scores, father's age (older) and child's diagnosis predicted father's distress. This study highlights differences and similarities in mothers' and fathers' psychological distress and identifies related risk factors. The results can guide interventions for mothers and fathers whose children undergo SCT based on their pre-SCT psychosocial risk.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Differences in mothers’ and fathers’ psychological distress after pediatric SCT: a longitudinal study

Barrera

Atenafu

Doyle

et al. 2011

Bone Marrow Transplant

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“…Research has shown that parents of children undergoing SCT can suffer from posttraumatic stress symptoms [25,27], depression [6,26], distress [35,39], and anxiety [6,25]. Maternal post-SCT anxiety and depression scores have been found to correlate with their children's QoL ratings at 6 months post-SCT [6].…”

Section: Discussionmentioning

confidence: 99%

Child and parental adaptation to pediatric stem cell transplantation

Vrijmoet-Wiersma

Kolk

Grootenhuis

et al. 2008

Support Care Cancer

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Goals of work Allogeneic pediatric stem cell transplantation (SCT) is a very intensive treatment with a high mortality and morbidity. The objectives of this study were to assess the (1) self-and proxy-reported health-related quality of life (HRQoL) compared to a norm group, (2) levels of parenting stress compared to a norm group, (3) differences in HRQoL and parenting stress pre-and post-SCT, and (4) effect of child age and parenting stress on selfand proxy-reported HRQoL pre-and post-SCT. Materials and methods Pre-and on average 10 months post-SCT, 21 children and adolescents and their parent(s) completed questionnaires on HRQoL and the mothers completed a measure of parenting stress. Main results Post-SCT, home functioning, physical functioning, and total HRQoL scores were lower than the norm group. We found stable HRQoL scores over time with the exception of the domain home functioning, which was rated lower post-SCT than pre-SCT. Parents reported lower HRQoL scores than the children pre-and post-SCT and younger children experienced better HRQoL than older children. Parenting stress was higher post-SCT than pre-SCT and high levels of parenting stress were predictive of poor parental ratings of child HRQoL post-SCT. Conclusions Ongoing psychosocial assessment post-SCT is necessary to target children with a lowered HRQoL and parents who experience elevated parenting stress who may be in greater need of more supportive care.

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“…Approximately 20% of mothers had clinically significant PTSD spectrum symptoms. This prevalence increased to nearly one third when subthreshold PTSD was included [17].…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 98%

Post-traumatic Stress Response to Life-Threatening Illnesses in Children and Their Parents

Stuber

Shemesh

2006

Child and Adolescent Psychiatric Clinics of North America

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Anxiety, Depressive, and Posttraumatic Stress Disorders Among Mothers of Pediatric Survivors of Hematopoietic Stem Cell Transplantation

Abstract: A subset of mothers of children who survive HSCT may require psychological intervention. Mothers who are most at risk are younger and evidence anxiety and depressive symptoms at the time of transplantation.

Cited by 88 publications

References 55 publications

Differences in mothers’ and fathers’ psychological distress after pediatric SCT: a longitudinal study

Differences in mothers’ and fathers’ psychological distress after pediatric SCT: a longitudinal study

Child and parental adaptation to pediatric stem cell transplantation

Post-traumatic Stress Response to Life-Threatening Illnesses in Children and Their Parents

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