Anxiety disorders are associated with verbal memory impairment in patients with Parkinson’s disease without dementia

Dissanayaka, N.; Forbes, Elana J.; Yang, Jihyun; Pourzinal, Dana; O’Sullivan, John D.; Mitchell, Leander K.; Copland, David A.; McMahon, Katie L.; Byrne, Gerard

doi:10.1007/s00415-021-10736-x

Cited by 6 publications

(12 citation statements)

References 61 publications

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“…Anxiety was associated with both motor and non-motor symptoms in PD patients [63, 78–80]. Accumulated studies have shown that higher anxiety level was associated with CI of PD patients [63, 64, 78]. Consistently, in our study, we also found MoCA scores and CI were associated with anxiety levels measured by STAI, which suggested anxiety exerted an essential impact on cognitive ability of PD patients.…”

Section: Discussionsupporting

confidence: 90%

“…CI can critically affect quality of life and has been proven to produce substantial economic impacts over the motor symptoms, even at the early stage of PD [61, 62]. According to previous literature, CI was associated with a multitude of clinical features, including age, education, baseline cognition, hypertension, motor symptoms, depressive symptoms, EDS, and anxiety levels [20–24, 63, 64]. In agreement with these results, we observed MoCA scores were significantly associated with age, UPDRS-III scores, ESS scores, GDS scores, and STAI scores (Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…PD patients displayed high anxiety levels than healthy controls [77]. Anxiety was associated with both motor and non-motor symptoms in PD patients [63, 78–80]. Accumulated studies have shown that higher anxiety level was associated with CI of PD patients [63, 64, 78].…”

Section: Discussionmentioning

confidence: 99%

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Structural network topology mediated cognitive impairment in Parkinson’s disease

Chen,

Li,

Zhou

et al. 2023

Preprint

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Cognitive impairment (CI) is one of the most prominent non-motor symptoms in Parkinson's disease (PD). How brain network abnormalities contribute to CI in PD patients remain largely unclear. The goal of this study is to explore whether aberrations of brain network topology were causally associated with cognitive decline in PD patients. PD patients receiving magnetic resonance imaging from Parkinson's Progression Markers Initiative (PPMI) database were specifically selected. According to the scores of Montreal Cognitive Assessment (MoCA), PD patients were classified into CI+ group (MoCA score ≤ 25) and CI- group (MoCA score > 25) to investigate whether clinical features and brain networks were significantly different between two groups. Mediation analysis was utilized to evaluate whether brain network alterations contributed to CI in PD patients. We revealed CI + group exhibited more severe non-motor symptoms compared to CI- group. In addition, age, excessive daytime sleepiness, and depressive symptoms were found to be significantly associated with CI of PD patients. Moreover, CI+ group exhibited statistically different local topological properties in structural network compared to CI- group. Furthermore, differential local topological metrics in structural network meditated the effects of age, excessive daytime sleepiness, and depression on cognitive decline of PD patients. Taken together, out study suggested that PD patients with CI exhibited notable disturbances of structural network topology, which mediated negative associations between of age, excessive daytime sleepiness, depression and cognitive decline of PD patients.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

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Structural network topology mediated cognitive impairment in Parkinson’s disease

Chen,

Li,

Zhou

et al. 2023

Preprint

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“…However, decline in card sorting and trail making is perhaps a reflection of increasing impairments becoming more pervasive and impacting adjacent cognitive domains. Notably, the synchronous decline in verbal memory and increase in anxiety aligns with the literature linking verbal memory deficits to anxiety in PD (Dissanayaka et al., 2022).…”

Section: Discussionsupporting

confidence: 83%

Longitudinal follow up of data‐driven cognitive subtypes in Parkinson's disease

Pourzinal,

Yang,

Sivakumaran

et al. 2023

Brain and Behavior

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AimThe dual syndrome hypothesis proposes that there are two cognitive subtypes in Parkinson's disease (PD): a frontal subtype with executive/attention impairment and gradual cognitive decline, and a posterior‐cortical subtype with memory/visuospatial deficits and rapid cognitive decline. We aimed to compare the rate of global cognitive decline between subtypes derived using data‐driven methods and explore their longitudinal performance within specific cognitive domains to better understand the prognosis of each subtype.MethodFrontal, posterior‐cortical, globally impaired, and cognitively intact PD subtypes were identified at baseline using k‐means clustering (N = 85), and 29 participants (34%) returned for follow‐up assessments on average 4.87 years from baseline. Linear mixed effects models compared progression of subtypes on global cognition; psychological symptoms; parkinsonism; and the memory, attention, executive, language, and visuospatial cognitive domains.ResultsThe frontal subtype was lost to attrition. While rate of change in parkinsonism, anxiety, and apathy differed between subtypes, there was no difference in the rate of global cognitive decline. However, the posterior‐cortical subtype declined most rapidly in verbal memory, card sorting, trail making, and judgement of line orientation (JLO), while the cognitively intact group declined most rapidly on verbal memory and semantic fluency. The globally impaired subtype declined most rapidly in JLO, although this should be interpreted with caution due to high attrition.ConclusionDespite limited sample size, the present study supports the differential progression of the posterior‐cortical subtype compared to cognitively intact and globally impaired PD. These results encourage further, large‐scale longitudinal investigations of cognitive subtypes in PD.

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“…Specifically, anxiety is associated with worse motor manifestations and complications, including freezing of gait 18,19,22,23 , impaired motor control 17 , dyskinesias and motor fluctuations 16 . Anxiety is also significantly associated with more severe non-motor symptoms, such as cognitive impairment 20,21,24 , sleep disorders 8,10 , physical pain 25 , frailty 25 , impulse control disorders 26,27 , autonomic dysfunction 11,28 , and depression 5,28,29 . Therefore, anxiety is an important non-motor symptom significantly shaping disease severity and outcomes 7,30 .…”

Section: Introductionmentioning

confidence: 99%

High-level anxiety is associated with worse clinical symptoms and aberrant brain networks in Parkinson’s disease

Chen,

Li,

Zhou

et al. 2023

Preprint

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BackgroundAnxiety is one of the most common psychiatric symptoms in Parkinson’s disease (PD). Whether anxiety shapes disease progression and brain network aberrations in PD remain largely unknown. The objective of present study is to investigate whether anxiety exacerbates clinical symptoms and brain network abnormalities of PD patients.MethodsPD patients performing magnetic resonance imaging from Parkinson’s Progression Markers Initiative (PPMI) database were specifically included. According to the scores of State-Trait Anxiety Inventory (STAI), PD patients were classified into lower quartile group (STAI score rank: 0%∼25%), interquartile group (STAI score rank: 26%∼75%), and upper quartile group (STAI score rank: 76%∼100%) based on their STAI score quartiles to investigate how anxiety affects clinical manifestations and brain networks.ResultsAnxiety was independently associated with both motor and non-motor symptoms of PD patients. Consistently, PD patients in the upper quartile group showed more severe non-motor symptoms compared to lower quartile group. Moreover, they also exhibited significantly different topological metrics in structural network compared to lower quartile group. Furthermore, we demonstrated that differential network metrics mediated the associations between anxiety and motor and non-motor symptoms of PD patients.ConclusionsPD patients with higher anxiety level exhibited more severe clinical manifestations and disruptions of brain network topology. Diverse structural network metrics were associated with motor and non-motor symptoms of PD patients.

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Anxiety disorders are associated with verbal memory impairment in patients with Parkinson’s disease without dementia

Cited by 6 publications

References 61 publications

Structural network topology mediated cognitive impairment in Parkinson’s disease

Structural network topology mediated cognitive impairment in Parkinson’s disease

Longitudinal follow up of data‐driven cognitive subtypes in Parkinson's disease

High-level anxiety is associated with worse clinical symptoms and aberrant brain networks in Parkinson’s disease

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