Anxiety disorders in adult ADHD: A frequent comorbidity and a risk factor for externalizing problems

Quenneville, Andréanne Filion; Kalogeropoulou, Eleni; Nicastro, Rosetta; Weibel, Sébastien; Chanut, Florence; Perroud, Nader

doi:10.1016/j.psychres.2022.114423

Cited by 17 publications

(14 citation statements)

References 39 publications

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“…ED is characterized by several transdiagnostic phenotypes, including inattention, hyperactivity, and poor impulse control [ 2 – 4 ]. As well as disrupting development and education, ED are associated with a range of debilitating comorbidities (bipolar disorder [ 5 ], depression [ 6 , 7 ], anxiety [ 8 – 10 ], substance misuse [ 11 , 12 ], and sleep disorders [ 13 ]).…”

Section: Introductionmentioning

confidence: 99%

adgrl3.1-deficient zebrafish show noradrenaline-mediated externalizing behaviors, and altered expression of externalizing disorder-candidate genes, suggesting functional targets for treatment

Fontana,

Reichmann,

Tilley

et al. 2023

Transl Psychiatry

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Externalizing disorders (ED) are a cause of concern for public health, and their high heritability makes genetic risk factors a priority for research. Adhesion G-Protein-Coupled Receptor L3 (ADGRL3) is strongly linked to several EDs, and loss-of-function models have shown the impacts of this gene on several core ED-related behaviors. For example, adgrl3.1−/− zebrafish show high levels of hyperactivity. However, our understanding of the mechanisms by which this gene influences behavior is incomplete. Here we characterized, for the first time, externalizing behavioral phenotypes of adgrl3.1−/− zebrafish and found them to be highly impulsive, show risk-taking in a novel environment, have attentional deficits, and show high levels of hyperactivity. All of these phenotypes were rescued by atomoxetine, demonstrating noradrenergic mediation of the externalizing effects of adgrl3.1. Transcriptomic analyses of the brains of adgrl3.1−/− vs. wild-type fish revealed several differentially expressed genes and enriched gene clusters that were independent of noradrenergic manipulation. This suggests new putative functional pathways underlying ED-related behaviors, and potential targets for the treatment of ED.

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Section: Introductionmentioning

confidence: 99%

adgrl3.1-deficient zebrafish show noradrenaline-mediated externalizing behaviors, and altered expression of externalizing disorder-candidate genes, suggesting functional targets for treatment

Fontana,

Reichmann,

Tilley

et al. 2023

Transl Psychiatry

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show abstract

“…However, it chimes with other studies that suggest it is the most common comorbidity experienced by individuals diagnosed with ADHD [ 26 ]. Unsurprisingly, individuals with concurrent anxiety have been shown to be more symptomatic, have lower occupational achievements, and increased levels of anger [ 27 ]. Help with anger management was also identified in our study, fitting with other research that found emotional dysregulation and outbursts of temper to be common in people with ADHD [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Service Users’ Perspectives on the Implementation of a Psychoeducation Group for People on the Waiting List of a Specialist ADHD Service: A Pilot Study

et al. 2023

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In the UK, Attention Deficit Hyperactivity Disorder and waits for assessment, diagnosis, and treatment are all growing problems. This study set out to gather service users’ suggestions as to how one specialist ADHD service could improve the experiences of people on their waiting list. Following a semi-structured focus group, an inductive thematic analysis of data yielded three themes: (1) support for psychoeducation in principle, (2) psychoeducation regarding the wider, holistic impact of ADHD, and (3) suggested structures and approaches, as well as (4) a set of general feedback that could inform service developments. Service users supported the notion of psychoeducation sessions to inform people on the waiting list about the wide range of potential impacts of ADHD, the most common psychiatric comorbidities, some potential coping strategies they could try, and the service they could ultimately expect to receive. Some form of one-to-one telephone support was also advocated, primarily to address their concerns about the lack of individualisation group psychoeducation could offer. The potential benefits of these suggestions combined with the low risk of adverse effects makes group psychoeducation a worthwhile waiting list initiative. However, as with any service development, it should be piloted and evaluated before being termed treatment as usual for the service.

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“…During the recent Covid-19 pandemic, it has been shown that suicidal thoughts in young adults have increased (Pirkis et al, 2021). There are also other mental disorders associated with increased suicidality, such as ADHD, (Quenneville et al, 2022) depression, substance-related disorders, psychosis (Bachmann, 2018) and repeated self-harming behaviour (Ekdahl et al, 2011). However, it appears that suicidal intention has been found in only 44% of clinically depressed patients and 66% of new-onset depression patients (Elzinga et al, 2020;Harmer et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Saving lives by asking questions: nurses’ experiences of suicide risk assessment in telephone counselling in primary health care

Wärdig

Engström

Carlsson

et al. 2022

Prim Health Care Res Dev

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Aim: To explore nurses’ experiences of suicide risk assessment in telephone counselling (TC) in primary health care (PHC). Background: Globally, priority is given to developing suicide prevention work in PHC. However, suicide risk assessments in TC are not included in these interventions even though these are a common duty of nurses in PHC. More expertise in the field can contribute to knowledge important for developing nurses’ tasks within PHC. Methods: A qualitative interview study was conducted with 15 nurses. Data were analysed using conventional content analysis. Findings: As suicide risk assessment in TC is a common duty for nurses in PHC, they need to be listened to and given the right conditions to perform this work. The nurses lack training in how to carry out suicide risk assessments and are forced to learn through experience. Intuition guides them in their work. A prerequisite for making correct assessments over the telephone is that the nurses are given time as well as the right competence. The PHC organisation needs to create these conditions. Furthermore, interventions to support suicide prevention need to include strategies to help nurses perform suicide assessment in TC.

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Anxiety disorders in adult ADHD: A frequent comorbidity and a risk factor for externalizing problems

Cited by 17 publications

References 39 publications

adgrl3.1-deficient zebrafish show noradrenaline-mediated externalizing behaviors, and altered expression of externalizing disorder-candidate genes, suggesting functional targets for treatment

adgrl3.1-deficient zebrafish show noradrenaline-mediated externalizing behaviors, and altered expression of externalizing disorder-candidate genes, suggesting functional targets for treatment

Service Users’ Perspectives on the Implementation of a Psychoeducation Group for People on the Waiting List of a Specialist ADHD Service: A Pilot Study

Saving lives by asking questions: nurses’ experiences of suicide risk assessment in telephone counselling in primary health care

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