Anxiety disorders: Where do we stand now? Current medicamentous treatment knowledge and future perspectives

Stojanović, Nikola; Nikolić, Gordana; Todorovska, Milica; Randjelović, Pavle J.; Stojiljković, Nenad; Radulović, Niko S.

doi:10.5937/afmnai1902091s

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…Aside from the emotional component, cognitive processing of "dangerous" stimuli has a significant role in anxiety. This cognitive component is linked to earlier anxiety experiences, such as cognitive worry about oneself, prospective consequences, and anticipatory negative future effects (35). Anxiety disorders in the general population tend to be chronic and, as a result, direct to longitudinal psychological complications (36).…”

Section: Discussionmentioning

confidence: 99%

Psychoeducational training for healthcare workers psychoeducational training for reducing the impact of COVID-19 pandemic on healthcare workers

Boiko,

Mats,

Zhyvotovska

et al. 2023

Acta fac medic Naissensis

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Introduction. Healthcare workers are increasingly exposed to long-term traumatic events in the context of the COVID-19 pandemic. Methods. We conducted a study that included 100 healthcare workers and 50 healthy individuals. We used the Perceived Stress Scale, Hospital Anxiety and Depression Scale, and Global Patient Impression for Improvement in the assessment of the psychological condition of respondents. To improve the psychoemotional state of health care workers, we proposed a program of psychoeducational training that was conducted at the workplace. After it, we reassessed the level of perceived stress, anxiety, and depression. Results. During the COVID-19 pandemic, in healthcare workers, the level of stress and anxiety was higher than in non-medical specialties, and the level of depression was not significantly different. The reduction of stress and anxiety was found. The subjective assessment of the improvement of the general condition indicates its positive dynamics after the psychoeducational training in both doctors and nurses. Conclusion. We showed the effectiveness of the proposed psychoeducational methodology for improving the psychoemotional condition of healthcare workers during the COVID-19 pandemic.

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Section: Discussionmentioning

confidence: 99%

Psychoeducational training for healthcare workers psychoeducational training for reducing the impact of COVID-19 pandemic on healthcare workers

Boiko,

Mats,

Zhyvotovska

et al. 2023

Acta fac medic Naissensis

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“…It takes roughly around 20 min for stressful stimuli to cause an increase in salivary cortisol levels [ 15 ]. The effects that cortisol exerts are mediated directly through the main brain structures, hippocampus, prefrontal cortex, etc., involved in stress processing and HPAA regulation [ 4 , 37 ]. The response of HPAA and the release of cortisol as a response to psychological stressors is suggested to be more intense in males than females [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

An Impact of Psychological Stress on the Interplay between Salivary Oxidative Stress and the Classic Psychological Stress‐Related Parameters

Stojanović

Randjelović

Pavlović

et al. 2021

Oxidative Medicine and Cellular Longevity

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Both oxidative and psychological (mental) stress are the likely culprits for several acute and chronic health disturbances, and adequate tests mimicking that are needed. Herein, in controlled laboratory surroundings, a PEBL (Psychology Experiment Building Language) test battery was used to evoke stress-related biological responses followed by tracking changes in saliva parameters. The study objectives were to determine the impact of psychological stress on selected salivatory parameters and to assess the correlation between the determined oxidative and stress parameters. The study was conducted on 36 healthy young subjects, mainly females ( n = 24 ). Before and following the completion of a battery of four PEBL tests, subjects’ saliva samples were collected. Stress-evoking changes in total antioxidant capacity and nitrite/nitrate levels, as oxidative stress parameters, and cortisol and immunoglobulin A (IgA), as parameters of psychological stress, were established and mutually correlated by comparing the values of the evaluated parameters pre- and post-PEBL test. The results showed that there is no change in the total salivary antioxidant capacity ( p > 0.05 ); however, there was a significant increase in nitrites/nitrates levels after the PEBL test ( p = 0.007 ). On the other hand, the determined cortisol levels after the test battery were found to be statistically significantly increased ( p = 0.025 ) when compared to the values obtained before the test, while the levels of IgA were found to be statistically significantly decreased ( p < 0.001 ). The only statistically significant correlation between the changes in the studied parameters was found to be the one between cortisol and IgA levels (Spearman’s Rö = -0.4). These results suggest that the short-term stress induced by the PEBL test does evoke changes in the salivary mental stress-related parameters (an increase in cortisol and nitrite/nitrate levels, and a decrease in IgA), but not in the total antioxidant capacity. They also indicate that the constructed PEBL four-test battery might represent an adequate laboratory stress-inducing paradigm.

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“…However, serotonin levels were increased in the amygdala, while simultaneously being decreased in the striatum and prefrontal cortex (29). One of the crucial neural structures involved in the anxiety is the locus coeruleus, which is essential for sleep regulation (30).…”

Section: Anxietymentioning

confidence: 99%

Relationship between sleep disorders and neuropsychiatric symptoms in Parkinson's disease: A narrative review

Shkodina¹,

Iengalychev²,

Tarianyk³

et al. 2022

Acta fac medic Naissensis

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Aim: The objective of this narrative review was to describe the versatile links between mental status and sleep in patients with Parkinson's disease. Methods: We searched randomized controlled studies, observational studies, meta-analyses, systematic reviews, and case reports written in English in PubMed during 2015 - 2021. Additionally, to ensure the completeness of the review, a second, more in-depth literature search was performed using the same electronic database with the search inquiries of increased specificity. Results: The information on pathophysiology, epidemiology, clinical features and risk factors was extracted and formed the basis for this review. Despite how widespread sleep disorders in Parkinson's disease are, there is no systematic information about their association with neuropsychiatric symptoms, such as depression, anxiety, impulse control disorders, apathy, cognitive impairment and psychosis. In this review, we described relationships between these non-motor symptoms of Parkinson's disease, their timeline occurrence, gap in knowledge and perspectives for further research. We suppose that early treatment of sleep disorders in patients with Parkinson's disease can reduce the incidence and extent of neuropsychiatric symptoms. Conclusion: We have demonstrated multiple, multidirectional relationships between sleep disorders and neuropsychiatric symptoms. However, some of them remain unexplored. The described knowledge can be applied to further study the possibility of influencing neuropsychiatric symptoms through the correction of sleep disorders in patients with different stages of Parkinson's disease.

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Anxiety disorders: Where do we stand now? Current medicamentous treatment knowledge and future perspectives

Cited by 6 publications

References 26 publications

Psychoeducational training for healthcare workers psychoeducational training for reducing the impact of COVID-19 pandemic on healthcare workers

Psychoeducational training for healthcare workers psychoeducational training for reducing the impact of COVID-19 pandemic on healthcare workers

An Impact of Psychological Stress on the Interplay between Salivary Oxidative Stress and the Classic Psychological Stress‐Related Parameters

Relationship between sleep disorders and neuropsychiatric symptoms in Parkinson's disease: A narrative review

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