Anxiety-Induced Plasma Norepinephrine Augmentation Increases Reactive Oxygen Species Formation by Monocytes in Essential Hypertension

Yasunari, Kenichi; Matsui, Toshiyasu; Maeda, Kensaku; Nakamura, Munehiro; Watanabe, Takanori; Kiriike, Nobuo

doi:10.1016/j.amjhyper.2005.10.027

Cited by 56 publications

(32 citation statements)

References 25 publications

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“…Individuals with higher plasma NE concentrations also have more severe anxiety symptoms and the concentrations of plasma NE of patients with anxiety disorders are drastically higher than those of healthy individuals (Yasunari et al, 2006). We conclude that high intensity aircraft noise exposure may similarly induce anxiety symptoms in rats.…”

Section: Levels Of Plasma Nementioning

confidence: 67%

Aircraft noise exposure affects rat behavior, plasma norepinephrine levels, and cell morphology of the temporal lobe

Zhou

et al. 2011

J. Zhejiang Univ. Sci. B

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Abstract:In order to investigate the physiological effects of airport noise exposure on organisms, in this study, we exposed Sprague-Dawley rats in soundproof chambers to previously recorded aircraft-related noise for 65 d. For comparison, we also used unexposed control rats. Noise was arranged according to aircraft flight schedules and was adjusted to its weighted equivalent continuous perceived noise levels (L WECPN ) of 75 and 80 dB for the two experimental groups. We examined rat behaviors through an open field test and measured the concentrations of plasma norepinephrine (NE) by high performance liquid chromatography-fluorimetric detection (HPLC-FLD). We also examined the morphologies of neurons and synapses in the temporal lobe by transmission electron microscopy (TEM). Our results showed that rats exposed to airport noise of 80 dB had significantly lower line crossing number (P<0.05) and significantly longer center area duration (P<0.05) than control animals. After 29 d of airport noise exposure, the concentration of plasma NE of exposed rats was significantly higher than that of the control group (P<0.05). We also determined that the neuron and synapsis of the temporal lobe of rats showed signs of damage after aircraft noise of 80 dB exposure for 65 d. In conclusion, exposing rats to long-term aircraft noise affects their behaviors, plasma NE levels, and cell morphology of the temporal lobe.

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Section: Levels Of Plasma Nementioning

confidence: 67%

Aircraft noise exposure affects rat behavior, plasma norepinephrine levels, and cell morphology of the temporal lobe

Zhou

et al. 2011

J. Zhejiang Univ. Sci. B

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“…23 Recent clinical evidence has shown that anxiety may increase reactive oxygen species formation independent of blood pressure in hypertensive patients. 37 Moreover, in mice, the expression levels of the antioxidant enzymes glyoxalase-1 and glutathione reductase are correlated with anxiety-related behavior. 38 Therefore, we hypothesized that mental stress would aggravate vascular oxidative stress and investigated lipid peroxidation, a global marker of oxidative stress, as well as the activity of the NADPH oxidase, an important source of Figure 5.…”

Section: Discussionmentioning

confidence: 99%

Heart Rate Contributes to the Vascular Effects of Chronic Mental Stress

Custodis

Gertz

Balkaya

et al. 2011

Stroke

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Background and Purpose-Vascular effects of mental stress are only partially understood. Therefore, we studied effects of chronic stress and heart rate (HR) on endothelial function and cerebral ischemia. Methods-129S6/SvEv mice were randomized to the I(f)-channel inhibitor ivabradine (10 mg/kg per day) or vehicle and underwent a chronic stress protocol for 28 days. Results-Stress increased HR from 514Ϯ10 bpm to 570Ϯ14 bpm, this was prevented by ivabradine (485Ϯ7 bpm).Endothelium-dependent relaxation of aortic rings was impaired in mice exposed to stress. HR reduction restored endothelial function to the level of naive controls. Vascular lipid hydroperoxides were increased to 333%Ϯ24% and vascular NADPH oxidase activity was upregulated to 223Ϯ38% in stressed mice, which was prevented by ivabradine. Stress reduced aortic endothelial nitric oxide synthase mRNA expression to 84%Ϯ3% and increased AT1 receptor mRNA to 168%Ϯ18%. Both effects were attenuated by HR reduction. In brain tissue, stress resulted in an upregulation of lipid hydroperoxides to 140%Ϯ11%, which was attenuated by HR reduction. Ivabradine increased brain capillary density in naive and in stressed mice.

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“…There is some evidence linking depression and anxiety to hypertension (28). One possible mechanism could be the presence of increased levels of circulating catecholamine in people with anxiety or depression (29). A recent quantitative review concluded for a moderate support of the use of psychological factors as predictors of the development of hypertension, especially anxiety, depression, and anger variables (30).…”

Section: Variablementioning

confidence: 99%

Clustering of psychiatric and somatic illnesses in the general population: multimorbidity and socioeconomic correlates

Andrade

Viana

Andreoni

et al. 2010

Braz J Med Biol Res

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The distribution of psychiatric disorders and of chronic medical illnesses was studied in a population-based sample to determine whether these conditions co-occur in the same individual. A representative sample (N = 1464) of adults living in households was assessed by the Composite International Diagnostic Interview, version 1.1, as part of the São Paulo Epidemiologic Catchment Area Study. The association of sociodemographic variables and psychological symptoms regarding medical illness multimorbidity (8 lifetime somatic conditions) and psychiatric multimorbidity (15 lifetime psychiatric disorders) was determined by negative binomial regression. A total of 1785 chronic medical conditions and 1163 psychiatric conditions were detected in the population concentrated in 34.1 and 20% of respondents, respectively. Subjects reporting more psychiatric disorders had more medical illnesses. Characteristics such as age range (35-59 years, risk ratio (RR) = 1.3, and more than 60 years, RR = 1.7), being separated (RR = 1.2), being a student (protective effect, RR = 0.7), being of low educational level (RR = 1.2) and being psychologically distressed (RR = 1.1) were determinants of medical conditions. Age (35-59 years, RR = 1.2, and more than 60 years, RR = 0.5), being retired (RR = 2.5), and being psychologically distressed (females, RR = 1.5, and males, RR = 1.4) were determinants of psychiatric disorders. In conclusion, psychological distress and some sociodemographic features such as age, marital status, occupational status, educational level, and gender are associated with psychiatric and medical multimorbidity. The distribution of both types of morbidity suggests the need of integrating mental health into general clinical settings.

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Anxiety-Induced Plasma Norepinephrine Augmentation Increases Reactive Oxygen Species Formation by Monocytes in Essential Hypertension

Abstract: Trait anxiety may increase plasma norepinephrine and increase ROS formation by MNC independent of BP in hypertensive patients.

Cited by 56 publications

References 25 publications

Aircraft noise exposure affects rat behavior, plasma norepinephrine levels, and cell morphology of the temporal lobe

Aircraft noise exposure affects rat behavior, plasma norepinephrine levels, and cell morphology of the temporal lobe

Heart Rate Contributes to the Vascular Effects of Chronic Mental Stress

Clustering of psychiatric and somatic illnesses in the general population: multimorbidity and socioeconomic correlates

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