2016
DOI: 10.1002/cncr.29876
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Anxiety, pain, and nausea during the treatment of standard‐risk childhood acute lymphoblastic leukemia: A prospective, longitudinal study from the Children's Oncology Group

Abstract: BACKGROUND This prospective study describes the procedure-related anxiety, treatment-related anxiety, pain, and nausea experienced by children with standard-risk acute lymphoblastic leukemia (ALL) during the first year of treatment. METHODS This study was undertaken at 31 Children’s Oncology Group (COG) sites. Eligible children who were 2 to 9.99 years old were enrolled in a COG trial for patients with newly diagnosed standard-risk ALL from 2005 to 2009. Parents completed a demographic survey at the baseline… Show more

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Cited by 88 publications
(105 citation statements)
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“…The majority of relatively recent published RCTs conducted in Europe and North America administered IM PEG‐ASP . A recently (2015) published RCT (DFC 005‐01) by Place et al .…”
Section: Discussionmentioning
confidence: 99%
“…The majority of relatively recent published RCTs conducted in Europe and North America administered IM PEG‐ASP . A recently (2015) published RCT (DFC 005‐01) by Place et al .…”
Section: Discussionmentioning
confidence: 99%
“…Vinblastine and vincristine were the first vinca alkaloids approved for clinical use as anticancer agents. Vincristine is approved and used for induction therapy in childhood ALL (77). Several studies in pediatric patients show that vincristine has a sensitizing effect with cytotoxic chemotherapy (78-80).…”
Section: Microtubule Inhibitorsmentioning
confidence: 99%
“…Pediatric patients with cancer are prone to sleep problems due to physical (i.e., tumor location, treatment, and toxicity) as well as psychosocial factors (i.e., anxiety and fatigue) . Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer and it requires an intensive treatment regimen of frequent chemotherapy administrations over the course of 2‐3 years .…”
Section: Introductionmentioning
confidence: 99%