Anxiety predicts impulsive-compulsive behaviours in Parkinson's disease: Clinical relevance and theoretical implications

Rosa, Elisa Di; Mapelli, Daniela; Ronconi, Lucia; Macchia, Eleonora; Gentili, Claudio; Bisiacchi, Patrizia; Edelstyn, Nicola M.J.

doi:10.1016/j.jpsychires.2022.01.052

Cited by 2 publications

(2 citation statements)

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“…The intention here is not to “explain” ICB in terms of abnormal modulation of the constructs of reward, impulsivity, negative affect or cognitive inflexibility. Instead, having identified that ICB is likely to reflect the confluence of changes in a number of different neural systems, future research should investigate the multiple constituent mechanisms [18]. So, in relation to reward, this might include, reward responsiveness, reward learning and reward valuation [19].…”

Section: Discussionmentioning

confidence: 99%

Identifying the Basic Dimensions of Medication-Triggered Impulsive Compulsive Behaviours in Parkinson’s Disease

2023

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Background: This review article integrates findings from published behavioural and neuroimaging studies of impulsive-compulsive behaviours (ICBs) in Parkinson’s disease, with the aim of identifying the basic correlates of these problematic and distressing behaviours. The underlying premise is that for any feature to be a reliable marker of ICBs, it should be evident across multiple levels of analyses. When changes are evident only at one level, but not in the others, their reliability as indicators of ICBs should be questioned. Summary: To this end, we draw on the conclusions from three published systematic reviews of dopamine metabolic processes in the striatum, functional magnetic resonance imaging and cognitive, affective, and motivational assessments of medicated Parkinson’s patients with and without ICBs (ICB+ and ICB−, respectively). The key findings are as follows: ICB+ showed abnormal dopaminergic of the striatum, including the brain network supporting reward processing. Fronto-striatal connectivity was also reduced. These findings are consistent with the broader evidence of psychological dysfunction, evident on assessments of cognitive control (goal-driven behaviour, impulsivity), reward-driven decision-making (temporal discounting, gambling), and elevated rates of self-report negative affect (anxiety, depression, anhedonia). The implications of these findings are discussed with reference to the research domain criteria and, relatedly, directions for future research. Key Messages: The identification of markers of ICB that allow early diagnosis, monitoring, and optimisation of therapy is an ambitious goal. And whilst we have pulled together a number of convergent findings identified using different paradigms, we are still some distance off understanding the mechanism(s) that increase vulnerability to ICB. It is our hope that this review spurs future studies to further investigate the interaction between motivation and cognition with the twin aims of identifying markers of ICB that have both clinical utility and function as outcome measures in therapeutic clinical trials.

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Section: Discussionmentioning

confidence: 99%

Identifying the Basic Dimensions of Medication-Triggered Impulsive Compulsive Behaviours in Parkinson’s Disease

2023

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“…Specifically, anxiety is associated with worse motor manifestations and complications, including freezing of gait 18,19,22,23 , impaired motor control 17 , dyskinesias and motor fluctuations 16 . Anxiety is also significantly associated with more severe non-motor symptoms, such as cognitive impairment 20,21,24 , sleep disorders 8,10 , physical pain 25 , frailty 25 , impulse control disorders 26,27 , autonomic dysfunction 11,28 , and depression 5,28,29 . Therefore, anxiety is an important non-motor symptom significantly shaping disease severity and outcomes 7,30 .…”

Section: Introductionmentioning

confidence: 99%

High-level anxiety is associated with worse clinical symptoms and aberrant brain networks in Parkinson’s disease

Chen,

Li,

Zhou

et al. 2023

Preprint

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BackgroundAnxiety is one of the most common psychiatric symptoms in Parkinson’s disease (PD). Whether anxiety shapes disease progression and brain network aberrations in PD remain largely unknown. The objective of present study is to investigate whether anxiety exacerbates clinical symptoms and brain network abnormalities of PD patients.MethodsPD patients performing magnetic resonance imaging from Parkinson’s Progression Markers Initiative (PPMI) database were specifically included. According to the scores of State-Trait Anxiety Inventory (STAI), PD patients were classified into lower quartile group (STAI score rank: 0%∼25%), interquartile group (STAI score rank: 26%∼75%), and upper quartile group (STAI score rank: 76%∼100%) based on their STAI score quartiles to investigate how anxiety affects clinical manifestations and brain networks.ResultsAnxiety was independently associated with both motor and non-motor symptoms of PD patients. Consistently, PD patients in the upper quartile group showed more severe non-motor symptoms compared to lower quartile group. Moreover, they also exhibited significantly different topological metrics in structural network compared to lower quartile group. Furthermore, we demonstrated that differential network metrics mediated the associations between anxiety and motor and non-motor symptoms of PD patients.ConclusionsPD patients with higher anxiety level exhibited more severe clinical manifestations and disruptions of brain network topology. Diverse structural network metrics were associated with motor and non-motor symptoms of PD patients.

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Anxiety predicts impulsive-compulsive behaviours in Parkinson's disease: Clinical relevance and theoretical implications

Cited by 2 publications

References 91 publications

Identifying the Basic Dimensions of Medication-Triggered Impulsive Compulsive Behaviours in Parkinson’s Disease

Identifying the Basic Dimensions of Medication-Triggered Impulsive Compulsive Behaviours in Parkinson’s Disease

High-level anxiety is associated with worse clinical symptoms and aberrant brain networks in Parkinson’s disease

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