Anxiety-Related Adverse Event Clusters After Janssen COVID-19 Vaccination — Five U.S. Mass Vaccination Sites, April 2021

Hause, Anne M.; Gee, Julianne; Johnson, Tara; Jazwa, Amelia; Marquez, Paige; Miller, Elizabeth M.; Su, John R.; Shimabukuro, Tom T.; Shay, David K.

doi:10.15585/mmwr.mm7018e3

Cited by 74 publications

(63 citation statements)

References 6 publications

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“…For example, Centers for Disease Control and Prevention, in a report published on April 30, 2021, recorded 64 anxiety-related events (syncope in 17) among 8,624 Janssen COVID-19 vaccine recipients. None of the event was labeled as serious [ 4 ].…”

Section: Mild Neurological Eventsmentioning

confidence: 99%

Spectrum of neurological complications following COVID-19 vaccination

2021

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Section: Mild Neurological Eventsmentioning

confidence: 99%

Spectrum of neurological complications following COVID-19 vaccination

2021

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“…51 Furthermore, 64 anxietyrelated adverse events (such as syncope, sweating or dizziness) were reported in clusters following Ad26.CoV2.S vaccination in the USA. 52 All were classified as non-serious, but the authors highlighted that the importance of recognising such events to provide reassurance to the affected individuals and to other members of public attending vaccination centres.…”

Section: Postapproval Surveillancementioning

confidence: 99%

Considerations for causality assessment of neurological and neuropsychiatric complications of SARS-CoV-2 vaccines: from cerebral venous sinus thrombosis to functional neurological disorder

Butler¹,

Tamborska

Wood

et al. 2021

J Neurol Neurosurg Psychiatry

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“…Specifically, if symptoms characteristic of i), ii), or iii) were observed at any time before, during, or after vaccination, they were determined to be ISRR according to the AEFI reporting manual [ 1 ]. Patients were excluded if drugs had been administered for adverse reactions because of the possibility of anaphylaxis [ 14 ], or if they had persistent symptoms at the time of completing the questionnaire, as CRPS, POTS, and CFS could not be ruled out [ [15] , [16] , [17] ].…”

Section: Methodsmentioning

confidence: 99%

Investigation of the incidence of immunisation stress-related response following COVID-19 vaccination in healthcare workers

Takano

Hirose

Yamasaki

et al. 2022

Journal of Infection and Chemotherapy

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Introduction Safe vaccination worldwide is critical to end the coronavirus disease 2019 (COVID-19) pandemic. We aimed to evaluate adverse reactions to vaccination using a web-based questionnaire and examine the risk factors for the occurrence of immunisation stress-related response (ISRR). Methods We conducted a questionnaire survey using Google Form® among the employees of St. Marianna University Hospital who had received the COVID-19 vaccine between April 2021 and May 2021, 1 week after the first and second vaccinations. We developed and used a questionnaire to identify individuals with ISRR according to the World Health Organization diagnostic criteria. A generalised linear mixed model was constructed with ISRR onset as the dependent variable, subjects as the random factor, and each parameter as a fixed factor. A multivariate model was constructed using the forced imputation method with factors that were significant in the univariate analysis. Results We enrolled 2,073 and 1,856 respondents in the first and second questionnaire surveys, respectively. Fifty-five and 33 ISRR cases were identified in the first and second vaccinations, respectively. In the univariate analysis, strong pre-vaccination anxiety (odds ratio [OR], 2.3; 95% confidence interval [CI], 1.30–4.12, p = 0·004) and history of allergy (OR, 1.6; 95% CI, 1.14–2.24, p = 0·007) were significant risk factors. Multivariate analysis also showed that strong pre-vaccination anxiety (OR, 2.1; 95% CI, 1.15–3.80, p = 0.016) and history of allergy (OR, 1.5; 95% CI, 1.09–2.15, p = 0.014) were significant risk factors. Conclusions Confirmation of allergy prior to vaccination and subsequent action are essential for addressing ISRR.

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Anxiety-Related Adverse Event Clusters After Janssen COVID-19 Vaccination — Five U.S. Mass Vaccination Sites, April 2021

Cited by 74 publications

References 6 publications

Spectrum of neurological complications following COVID-19 vaccination

Spectrum of neurological complications following COVID-19 vaccination

Considerations for causality assessment of neurological and neuropsychiatric complications of SARS-CoV-2 vaccines: from cerebral venous sinus thrombosis to functional neurological disorder

Investigation of the incidence of immunisation stress-related response following COVID-19 vaccination in healthcare workers

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