2019
DOI: 10.1037/abn0000422
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Anxiety sensitivity and intolerance of uncertainty facilitate associations between generalized Pavlovian fear and maladaptive avoidance decisions.

Abstract: Generalization of Pavlovian fear to safe stimuli resembling conditioned-danger cues (CS+) is a widely accepted conditioning correlate of clinical anxiety. Though much of the pathogenic influence of such generalization may lie in the associated avoidance, few studies have assessed maladaptive avoidance decisions associated with Pavlovian generalization. Lab-based assessments of this process, here referred to as aversive Pavlovian-instrumental covariation during generalization (APIC-G), have recently begun. The … Show more

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Cited by 59 publications
(49 citation statements)
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“…Based on a reviewer's suggestion, we exploratively looked at the modulatory role of trait anxiety (Haddad et al, 2012) as well as anxiety sensitivity (Hunt et al, 2019) on context-dependent fear generalization. To this purpose, mean scores for the two generalization test phases were calculated for each dependent variable.…”
Section: Statistical Analysesmentioning
confidence: 99%
“…Based on a reviewer's suggestion, we exploratively looked at the modulatory role of trait anxiety (Haddad et al, 2012) as well as anxiety sensitivity (Hunt et al, 2019) on context-dependent fear generalization. To this purpose, mean scores for the two generalization test phases were calculated for each dependent variable.…”
Section: Statistical Analysesmentioning
confidence: 99%
“…In rodents, for example, rats successfully learn to jump on a safe platform during a CS+ to avoid aversive foot‐shocks but otherwise leave the platform to approach food (Bravo‐Rivera et al, 2014, 2015; Martínez‐Rivera et al, 2019). In human paradigms, avoidance responses are likewise in conflict with appetitive outcomes (e.g., incentives for approach; Pittig, 2019; Pittig & Dehler, 2019; Pittig et al, 2014) or inflict other costs (e.g., temporal delay, physical effort; Hunt et al, 2019; Meulders et al, 2016; van Meurs et al, 2014; Rattel et al, 2017). Such competing outcomes strongly modulate avoidance (for an overview see Pittig et al, 2020).…”
Section: Introductionmentioning
confidence: 99%
“…Along with these cognitiveaffective responses, AS may play a role in key biobehavioral mechanisms underlying PTSS development and maintenance (Nees et al, 2018). For example, AS may facilitate maladaptive fear conditioning by increasing the overgeneralization of conditioned fear to safety cues, promoting avoidance in response to such cues, and hindering fear extinction on both behavioral and neural levels (Hunt et al, 2019;van Well et al, 2012). It is also possible that AS plays a role in increased stress reactivity, as some evidence suggests that AS is associated with altered hypothalamic-pituitary-axis reactivity to stressors (Sjörs et al, 2010), although findings regarding this have been mixed (McCaul et al, 2017).…”
Section: Discussionmentioning
confidence: 99%