Anxiety symptoms are the strongest predictor of quality of life in temporal lobe epilepsy

Lima, Ellen Marise; Gois, Juliana; Paiva, Maria L.; Vincentiis, Silvia; Moschetta, Sylvie P.; Valente, Kette D.

doi:10.1016/j.seizure.2021.03.021

Cited by 14 publications

(13 citation statements)

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“…Available screening tools have been discussed [e.g., ( 9 , 10 )]. Presently, in both epileptological research and clinical care of PWE, a number of questionnaires with different aims have been used, including scales that explicitly or implicitly address the multiple aspects of anxiety, e.g., assessments of quality of life ( 11 – 13 ), social functioning ( 14 ), health locus of control ( 15 ), or psychological flexibility ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Anxiety in Patients With Epilepsy: A Literature Review

2022

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ObjectiveApproximately 20% of people with epilepsy (PWE) suffer from anxiety. These fears are quite diverse and may manifest periictally or interictally, be part of the seizure's semiology, or an expression of reactive psychological distress from seizures themselves. Our review addresses the question of what screening tools are used in clinical care and epileptological research to capture the complexity of epilepsy-specific anxieties.MethodOn 2021/11/11, we entered a search string in PubMed that covered our research interest as completely as possible. We also screened the bibliographies of our findings and followed PubMed's recommendations. From the assessments we found in the included studies, we extracted domains that represent the range of manifestations of anxiety, in order to compare the tools and to discuss to what extent they are suitable for assessing epilepsy-specific anxieties.ResultsWe screened 1,621 abstracts. In total, we identified 24 different anxiety assessments. In addition to the psychiatric assessments in use, we found 7 tools that were designed to assess epilepsy-specific anxieties. The latter focus on different aspects of epilepsy-specific anxieties. In some cases, the conceptual frameworks are not sufficiently transparent or divergent.ConclusionBecause a diagnosis of epilepsy can result in, or seizures may appear as, anxiety, it is important to better understand this psychological burden and address it therapeutically, if necessary. There is a need for screening tools that integrate specific points of a variety of assessments, so as to cover the broad range of epilepsy-specific fears. None of the assessments we found meets this integrative perspective. At the same time, the appropriate design of such a required tool presupposes a conceptual framework of what should be considered as epilepsy-specific anxiety.

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Section: Introductionmentioning

confidence: 99%

Assessment of Anxiety in Patients With Epilepsy: A Literature Review

2022

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“…However, accumulating studies revealed that the overproduction of reactive oxygen species (ROS) and free radicals is also involved in the pathogenesis of TLE ( Frantseva et al., 2000 ; Shin et al., 2011 ; Kandeda et al., 2021a ). Around half of people with TLE have frequent complaints about neuropsychiatric disorders such as anxiety and depression ( Kimiskidis and Valeta, 2012 ; Gur-Ozmen et al., 2017 ; Lima et al., 2021 ). Their interictal anxiety behavior is associated with adverse outcomes such as drug resistance, poor surgical outcomes, and worse quality of life ( Chapouthier and Venault, 2001 ; Vazquez and Devinsky, 2003 ; Kimiskidis and Valeta, 2012 ; Lima et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Around half of people with TLE have frequent complaints about neuropsychiatric disorders such as anxiety and depression ( Kimiskidis and Valeta, 2012 ; Gur-Ozmen et al., 2017 ; Lima et al., 2021 ). Their interictal anxiety behavior is associated with adverse outcomes such as drug resistance, poor surgical outcomes, and worse quality of life ( Chapouthier and Venault, 2001 ; Vazquez and Devinsky, 2003 ; Kimiskidis and Valeta, 2012 ; Lima et al., 2021 ). Anxiety disorders in patients with TLE are due to multiple factors including multi-drug therapy, drug resistance, brain injury, and recurrent seizures ( Chapouthier and Venault, 2001 ; Vazquez and Devinsky, 2003 ; Kimiskidis and Valeta, 2012 ; Lima et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Their interictal anxiety behavior is associated with adverse outcomes such as drug resistance, poor surgical outcomes, and worse quality of life ( Chapouthier and Venault, 2001 ; Vazquez and Devinsky, 2003 ; Kimiskidis and Valeta, 2012 ; Lima et al., 2021 ). Anxiety disorders in patients with TLE are due to multiple factors including multi-drug therapy, drug resistance, brain injury, and recurrent seizures ( Chapouthier and Venault, 2001 ; Vazquez and Devinsky, 2003 ; Kimiskidis and Valeta, 2012 ; Lima et al., 2021 ). Also, anxiety disorders and TLE seem to share common neurobiology with the involvement amygdala and hippocampus ( Chapouthier and Venault, 2001 ; Vazquez and Devinsky, 2003 ; Kimiskidis and Valeta, 2012 ; Lima et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Anxiety disorders in patients with TLE are due to multiple factors including multi-drug therapy, drug resistance, brain injury, and recurrent seizures ( Chapouthier and Venault, 2001 ; Vazquez and Devinsky, 2003 ; Kimiskidis and Valeta, 2012 ; Lima et al., 2021 ). Also, anxiety disorders and TLE seem to share common neurobiology with the involvement amygdala and hippocampus ( Chapouthier and Venault, 2001 ; Vazquez and Devinsky, 2003 ; Kimiskidis and Valeta, 2012 ; Lima et al., 2021 ). It is well known that the GABA inhibitory network plays an important role in the regulation of emotional responses in multiple pathological conditions.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An aqueous extract of Khaya senegalensis (Desv.) A. Juss. (Meliaceae) prevents seizures and reduces anxiety in kainate-treated rats: modulation of GABA neurotransmission, oxidative stress, and neuronal loss in the hippocampus

Kandeda¹,

Lewale²,

Djeuzong³

et al. 2022

Heliyon

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Determinants of health‐related quality of life of patients with focal epilepsy: A systematic literature review

Engelhart,

Marcin,

Lerner

et al. 2024

Epileptic Disorders

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ObjectiveFocal epilepsy can have significant negative impacts on a person's health‐related quality of life (HRQoL). Although studies have been published on HRQoL in persons with focal epilepsy (PWFE), determinants of HRQoL have not been comprehensively examined. This systematic literature review (SLR) queried existing literature to identify aspects associated with HRQoL in PWFE without focus on resective epilepsy surgery, with an interest in identifying modifiable determinants for medical/nonmedical interventions.MethodsThis SLR was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Searches were conducted in PubMed and Google Scholar for articles published from January 1, 1900, to February 19, 2023, reporting on the association between HRQoL or employability and a range of demographic, psychosocial, or epilepsy‐related factors and comorbidities in PWFE.ResultsA total of 879 abstracts were identified, with 126 manuscripts reviewed and 37 studies selected for inclusion that quantified the relationship between HRQoL and the variable of interest by multivariate (N = 21) or univariate only (N = 15) methods; 10 multivariate models also included univariate data. In adjusted models, the most commonly examined determinants of HRQoL included depression (n = 15/21), number of antiseizure medications (ASMs; n = 13/21), seizure frequency (continuous seizure count, n = 11/21; seizure freedom, n = 5/21), anxiety (n = 10/21), duration of disease (n = 9/21), and cognition (n = 9/21). Depression, anxiety, and cognition were frequently seen as significant contributors to HRQoL when studied (14/15 [93%], 9/10 [90%], and 7/9 [78%], respectively). Among concepts studied less frequently, ASM severity/adverse event burden was significant each time examined (in 5/19 studies). Attainment of seizure freedom and employability was significant 75% (n = 3/4) and 72% (n = 5/7) of the time, respectively.SignificancePoor HRQoL in PWFE can be attributed to a multitude of factors, including depression, anxiety, factors in disease management, and employability. An unmet need remains in addressing elements associated with poor HRQoL in this population.

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Anxiety symptoms are the strongest predictor of quality of life in temporal lobe epilepsy

Cited by 14 publications

References 28 publications

Assessment of Anxiety in Patients With Epilepsy: A Literature Review

Assessment of Anxiety in Patients With Epilepsy: A Literature Review

An aqueous extract of Khaya senegalensis (Desv.) A. Juss. (Meliaceae) prevents seizures and reduces anxiety in kainate-treated rats: modulation of GABA neurotransmission, oxidative stress, and neuronal loss in the hippocampus

Determinants of health‐related quality of life of patients with focal epilepsy: A systematic literature review

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