Anxiogenic-like activity of 3,4-methylenedioxy-methamphetamine (“Ecstasy”) in the social interaction test is accompanied by an increase of c-fos expression in mice amygdala

Navarro, José Francisco; Rivera, Alicia; Maldonado, E.; Cavas, M.; Calle, Adélaïda de la

doi:10.1016/j.pnpbp.2003.10.016

Cited by 44 publications

(31 citation statements)

References 33 publications

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“…MDMA has been shown to induce oxidative stress and thus increase expressions of c-fos and HO-1 genes in the brain (Salzmann et al, 2003;Navarro et al, 2004;Puerta et al, 2010). However, expressions of c-fos and HO-1 appeared to be unchanged in MDMA pups ( Fig.…”

Section: Discussionmentioning

confidence: 90%

Maternal MDMA administration in mice leads to neonatal growth delay

et al. 2014

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-The psychoactive recreational drug 3,4-methylenedioxymethamphetamine (MDMA) is widely abused. The fact that MDMA induces neurotoxic damage in serotonergic nerve endings is well known. However, the effects of MDMA on pregnant and neonatal animals remain unknown. Therefore, we studied the effects of gestational exposure to MDMA on birth, growth, and behavior of pups. Female BALB/c mice were orally administered either water (10 ml/kg) or MDMA (20 mg/10 ml/kg) from gestational day 1 to postnatal day (P) 21. MDMA did not affect the birth rate, but the survival rate of the pups significantly decreased. A significant reduction in body weight gain was observed in pups from MDMAadministered dams during P3-P21. Maternal MDMA treatment caused an attenuated cliff avoidance reaction and decreased motor function in the pups, as determined by the wire hanging test. These results suggest that MDMA treatment during pregnancy and lactation causes growth retardation and dysfunction of motor neurons in mouse pups.

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Section: Discussionmentioning

confidence: 90%

Maternal MDMA administration in mice leads to neonatal growth delay

et al. 2014

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“…In adolescent mice, the highest dose increased this behavior, but no significant effects were observed after the administration of lower doses. The increase in nonsocial exploration after receiving several drugs has been related to a rise in the level of anxiety [Navarro et al, 2004]. However, as this behavior is greatly influenced by changes in locomotion, such an increase could be interpreted in different ways.…”

Section: Discussionmentioning

confidence: 99%

“…Changes in time allocated to social investigation during agonistic encounters are also said to reflect changes in anxiety [Navarro et al, 2004[Navarro et al, , 2006Redolat et al, 1991Redolat et al, , 2005a. Thus, it has been proposed that an increase in time allocated to this category is reflective of anxiolytic activity, whereas a decrease is indicative of anxiogenic activity.…”

Section: Discussionmentioning

confidence: 99%

Differential sensitivity to the effects of nicotine and bupropion in adolescent and adult male OF1 mice during social interaction tests

Gómez

Carrasco

Redolat

2008

Aggressive Behavior

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Few studies have compared the action of both nicotine (NIC) and bupropion (BUP), an antidepressant used to treat NIC dependence, on social and aggressive behavior at different ages. This study aims to determine whether these drugs produce differential effects in adolescent (postnatal day: 36-37) and adult (postnatal day: 65-66) mice that have been housed individually for 2 weeks in order to induce aggressive behavior. Mice received BUP (40, 20, or 10 mg/kg), NIC (1, 0.5, and 0.25 mg/kg as base), or vehicle earlier to a social interaction test. BUP (40 mg/kg) decreased social investigation and increased nonsocial exploration in both adolescent and adult mice. The same effects were also observed in adult mice administered with a lower dose of the same drug (20 mg/kg). In adolescents, NIC (1 mg/kg) decreased social investigation, but this effect did not reach statistical significance in adults. In conclusion, a differential sensitivity to the effects of NIC or BUP emerged in some of the behavioral categories when the two age groups were compared.

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“…As shown in Table 2, selected hallucinogens drugs affect both c-fos and cortisol levels in adult zebrafish. Notably, altered c-fos brain expression and cortisol/corticosterone levels have been reported in various mammalian models following hallucinogenic drugs, including LSD, 163,164 MDMA, 165,166 ketamine, 167,168 and PCP. 113,169 Zebrafish display a welldeveloped neuroendocrine system 74,170 and show high sensitivity of their CNS proto-oncogene expression to various experimental manipulations.…”

Section: ■ Modeling Hallucinogenic Drug Action In Zebrafishmentioning

confidence: 99%

Perspectives on Zebrafish Models of Hallucinogenic Drugs and Related Psychotropic Compounds

Neelkantan

Mikhaylova

Stewart

et al. 2013

ACS Chem. Neurosci.

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Among different classes of psychotropic drugs, hallucinogenic agents exert one of the most prominent effects on human and animal behaviors, markedly altering sensory, motor, affective, and cognitive responses. The growing clinical and preclinical interest in psychedelic, dissociative, and deliriant hallucinogens necessitates novel translational, sensitive, and high-throughput in vivo models and screens. Primate and rodent models have been traditionally used to study cellular mechanisms and neural circuits of hallucinogenic drugs' action. The utility of zebrafish (Danio rerio) in neuroscience research is rapidly growing due to their high physiological and genetic homology to humans, ease of genetic manipulation, robust behaviors, and cost effectiveness. Possessing a fully characterized genome, both adult and larval zebrafish are currently widely used for in vivo screening of various psychotropic compounds, including hallucinogens and related drugs. Recognizing the growing importance of hallucinogens in biological psychiatry, here we discuss hallucinogenic-induced phenotypes in zebrafish and evaluate their potential as efficient preclinical models of drug-induced states in humans.

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Anxiogenic-like activity of 3,4-methylenedioxy-methamphetamine (“Ecstasy”) in the social interaction test is accompanied by an increase of c-fos expression in mice amygdala

Cited by 44 publications

References 33 publications

Maternal MDMA administration in mice leads to neonatal growth delay

Maternal MDMA administration in mice leads to neonatal growth delay

Differential sensitivity to the effects of nicotine and bupropion in adolescent and adult male OF1 mice during social interaction tests

Perspectives on Zebrafish Models of Hallucinogenic Drugs and Related Psychotropic Compounds

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