Anxiolytic activity of aerial part of Mercurialis annua aqueous extract in using light/dark and hole board tests

Doukkali, Zouhra

doi:10.21767/2471-9633-c1-006

Cited by 2 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The dried, powdered plant also promotes wound healing [30] . Several studies have confirmed the various traditional reputations [18,23,31] . Mercurialis annua is plenty of biological effects, such as anti-cancer [23] , anti-inflammatory [23] , anti-microbial [23] , anti-anxiety [18] , and anxiolytic effects [31] .…”

Section: Introductionmentioning

confidence: 82%

“…Several studies have confirmed the various traditional reputations [18,23,31] . Mercurialis annua is plenty of biological effects, such as anti-cancer [23] , anti-inflammatory [23] , anti-microbial [23] , anti-anxiety [18] , and anxiolytic effects [31] . Many reports have demonstrated that pharmacological activities of M. annua are related to their rich content of phenolic compounds such as rutin, narcissin, flavonol glycosides [32][33][34] .…”

Section: Introductionmentioning

confidence: 82%

“…The aerial parts are known for diuretic, galactogenic, and aphrodisiac properties [10] , and are used to treat cancer and sciatica [14], and as a styptic [15] , the leaves are frequently used against burns, rheumatism, and urinary diseases [14][15][16]. Several pharmacological and phytochemical works have confirmed their traditional uses in folk medicine [11,17,18] . The methanolic extract of the Urtica urens aerial part has proved to have anxiolytic activity [11] , free radical scavenging activity, and antimicrobial potential [19] .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Radical-Scavenging Effect, Ferric Reducing Ability and Phytochemical Analysis of Urtica urens (L.) and Mercurialis annua (L.)

Zouhra,

El Jemli,

Bouyahya

et al. 2023

Prog Micobes Mol Biol

View full text Add to dashboard Cite

Important Moroccan medicinal plants known for their food and medicinal potential include Urtica urens and Mercurialis annua. We examined the antioxidant activity of the methanolic and aqueous extracts by several in vitro systems of the assay, namely the ferric reducing/antioxidant power (FRAP) assay, the DPPH radical-scavenging activity, and the ABTS free radical-scavenging capacity. In addition, all active extracts were subjected to phytochemical screening to determine the key groups of chemicals implicated in their therapeutic activity. Total phenolic and flavonoid concentrations were also measured to see how they affected the antioxidant properties of the plant extracts. The extracts of Urtica urens and Mercurialis annua were found to have different levels of antioxidant effect in the systems tested. Based on the three different antioxidant assays, the Mercurialis annua extracts showed the highest values of antioxidant ability, based on the three used assays. Phytochemical testing of studied extracts revealed the presence of flavonoids, anthocyanins, and tannins. Total phenol and flavonoid contents were shown to provide the highest association with different antioxidant methods. The present study provides evidence that the extracts of Urtica urens and Mercurialis annua are a potential source of natural antioxidants, and this justifies their uses in Moroccan traditional medicine.

show abstract

Section: Introductionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Radical-Scavenging Effect, Ferric Reducing Ability and Phytochemical Analysis of Urtica urens (L.) and Mercurialis annua (L.)

Zouhra,

El Jemli,

Bouyahya

et al. 2023

Prog Micobes Mol Biol

View full text Add to dashboard Cite

show abstract

“…To evaluate the anxiolytic effect of the chloroform extract, mirror chamber, light/dark box and elevated plus-maze (EPM) animal models were used [12][13] and the experimental protocol is given in Figure 1.…”

Section: Animal Models Used For Anti-anxiety Activitymentioning

confidence: 99%

Anxiolytic Potential of Chloroform Extract of Ziziphus mauritiana Lam. Leaves in Mice

Kumar¹,

Kaur²,

Singh³

et al. 2023

Ind. J. Pharm. Edu. Res

View full text Add to dashboard Cite

Introduction: With a tremendous spike in the cases of anxiety in recent years, scientists are looking for herbal drug alternatives for its treatment as all the conventional medication options available in the market have side effects and lead to dependence. Ethnopharmacological reports revealed the usefulness of Ziziphus mauritiana Lam. for anxiety and depression. Therefore, it was envisaged to explore this plant's possible anxiolytic activity. Objectives: The purpose of the present study was to evaluate the anxiolytic activity of Z. mauritiana leaves based on its ethno pharmacological relevance. Materials and Methods: Anxiolytic activity of the chloroform leaf extract of this plant was determined with the use of animal models elevated plus maze, mirrored chamber and light/dark box test. The chloroform extract was given orally to mice at 200 and 400 mg/kg and number of entries and time spent in the animal models was observed. The extract was then subjected to PTLC and a pentacyclic triterpenoid (RJ11) was isolated which was then characterized using spectroscopic techniques. Molecular docking studies of isolated compound RJ11 was done on GABA A receptors. Results: The chloroform extract showed significant anxiolytic effect in mirrored chamber, elevated plus maze and light/ dark models at the dose of 400mg/kg. Molecular docking studies of isolated compound RJ11 on GABA A receptors revealed good binding affinity and interactions with central benzodiazepine binding site on GABA A that may be responsible for the anxiolytic effect of this plant. Conclusion: The chloroform extract of leaves of Z. mauritiana Lam. possess anxiolytic effect which may be attributed to binding affinity of pentacyclic triterpenoid present in this plant with GABA A receptors on its benzodiazepines receptor site.

show abstract

Anxiolytic activity of aerial part of Mercurialis annua aqueous extract in using light/dark and hole board tests

Cited by 2 publications

References 0 publications

Radical-Scavenging Effect, Ferric Reducing Ability and Phytochemical Analysis of Urtica urens (L.) and Mercurialis annua (L.)

Radical-Scavenging Effect, Ferric Reducing Ability and Phytochemical Analysis of Urtica urens (L.) and Mercurialis annua (L.)

Anxiolytic Potential of Chloroform Extract of Ziziphus mauritiana Lam. Leaves in Mice

Contact Info

Product

Resources

About