Anxiolytic and antidepressant-like effects of the hydroalcoholic extract from Aloysia polystachya in rats

Mora, Sergio; Dı́az-Véliz, Gabriela; Millán, Raquel; Lungenstrass, H.; Quirós, Steve; Coto-Morales, Teresita; Hellión-Ibarrola, M.C.

doi:10.1016/j.pbb.2005.09.007

Cited by 71 publications

(47 citation statements)

References 15 publications

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“…The reduction in the number of rearings and crossings may suggest that S. guaraniticum caused alterations in the activity of the central nervous system (Morais, Barbosa-Filho, Almeida, 1998;Mora et al, 2005;Yasar et al, 2012). Further, it is interesting to note that the behavioral effects were more pronounced 48 h after treatment, and the behavior of the rats was similar to the controls at day 14 after treatment.…”

Section: Discussionmentioning

confidence: 91%

Safety assessment and behavioral effects of Solanum guaraniticum leaf extract in rats

Bonfanti

Bitencourt

Bona

et al. 2016

Braz. J. Pharm. Sci.

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Solanum guaraniticum is a medicinal plant traditionally used to treat gastric and liver diseases. However, there is no documented evidence corroborating its safety. The present study evaluated the potential toxicity of S. guaraniticum leaf extract after acute administration in rats. Single doses of the extract (1.250, 2.500, and 5.000 mg/kg) were administered by gavage, and the rats were then monitored for 48 h and/or 14 days. Mortality, acute signs of toxicity, and general activity in the open field test were assessed as well as hematological and biochemical parameters, enzymatic activity (δ-aminolevulinate dehydratase and acetylcholinesterase), and oxidative stress parameters (lipid peroxidation level, nonprotein thiol content, tissue catalase activity, and serum ferrous reducing power). Phytochemical analysis was also performed by HPLC. The results showed that extract administration produced no deaths (LD 50 > 5,000 mg/kg), and no significant adverse effects regarding food consumption, body weight gain, gross pathology, or other parameters. However, the open field tests showed a decrease in spontaneous activity (crossing and rearing) mainly at 48 h after treatment. The results suggest that S. guaraniticum extract is not acutely toxic, but causes alterations in central nervous system activity.Uniterms: Solanum guaraniticum/leaf extract/toxicity. Solanum guaraniticum/phytochemistry. Medicinal plants. Solanaceae.Solanum guaraniticum é uma planta medicinal tradicionalmente usada para tratar doenças gástricas e hepáticas. Porém, não há evidências documentadas sobre sua segurança. O presente estudo avaliou a toxicidade do extrato das folhas de S. guaraniticum após administração aguda em ratos. Doses únicas do extrato (1.250, 2.500 and 5.000 mg/kg) foram administradas por gavagem e os animais foram monitorados por 48 h ou 14 dias. Mortalidade, sinais de toxicidade aguda e atividade geral, através do teste de campo aberto, foram analisados, assim como parâmetros hematológicos e bioquímicos, atividades enzimáticas (δ-aminolevulinato desidratase e acetilcolinesterase) e parâmetros de estresse oxidativo (nível de peroxidação lipídica, conteúdo de tióis não protéicos, atividade da catalase em tecidos e poder redutor em soro). A análise fitoquímica também foi realizada por HPLC. Os resultados mostraram que a administração do extrato não provoca mortes (LD 50 >5.000 mg/kg) ou efeitos adversos significativos com relação ao consumo de comida, ganho de peso corporal, análise patológica, entre outros. Entretanto, o teste de campo aberto mostrou uma diminuição na atividade espontânea geral (cruzamentos e levantadas), principalmente em 48 h após o tratamento. Portanto, nossos resultados sugerem que o extrato de S. guaraniticum não é agudamente tóxico, mas causa alterações na atividade do sistema nervoso central. Unitermos:Solanum guaraniticum/extrato de folhas/toxicidade. Solanum guaraniticum/fitoquímica. Plantas medicinais. Solanaceae.

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Section: Discussionmentioning

confidence: 91%

Safety assessment and behavioral effects of Solanum guaraniticum leaf extract in rats

Bonfanti

Bitencourt

Bona

et al. 2016

Braz. J. Pharm. Sci.

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“…(Verbenaceae), planta aromática nativa da América do Sul e popularmente usada no tratamento de desordens gatrintestinais e como sedativa, possui atividades ansiolítica, no labirinto em cruz elevado; e antidepressiva, no teste da natação forçada, em roedores. Estudos químicos reportaram a presença de muitos compostos monoterpênicos no óleo volátil desta planta, principalmente a-e b-tujona e carvona, juntamente com limoneno, sabineno, b-pineno, carvacrol e eucarvona (Mora et al, 2005). Já a exposição prolongada ao óleo volátil de limão (Citrus limon L.), que possui grande quantidade de limoneno, provocou ação ansiogênica no labirinto em cruz elevado (Ceccarelli et al, 2004 (Salah & Jäger, 2005).…”

Section: Outros Monoterpenóidesunclassified

Terpenóides com atividade sobre o Sistema Nervoso Central (SNC)

Passos¹,

Arbo²,

Rates³

et al. 2009

Rev. bras. farmacogn.

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RESUMO:Os terpenóides constituem um vasto grupo de metabólitos secundários com ações sobre o SNC, destacando-se suas atividades sedativa, ansiolítica, antinociceptiva, anticonvulsivante, pró-convulsivante e alucinógena. Neste trabalho foi realizada uma revisão bibliográfica sobre terpenóides com ações descritas no SNC, enfocando moléculas e sistemas neurotransmissores relacionados com sua atividade. As substâncias abordadas encontram-se divididas em mono, sesqui, di, tri e meroterpenóides e incluem compostos isolados e plantas que apresentam ação principalmente sobre os sistemas neurotransmissores GABAérgico, glutamatérgico, dopaminérgico e opióide.Unitermos: Terpenóides, sistema nervoso central, neurotransmissores.ABSTRACT: "Terpenoids with activity in the Central Nervous System (CNS)". The terpenoids are a large group of secondary metabolites which display many activities in the CNS, such as sedative, ansiolytic, antinociceptive, anticonvulsant, pro-convulsant and hallucinogenic. In this work we performed a research on terpenoids that exert effects on the CNS, focusing molecules and neurotransmitter systems related to their actions. The substances approached were classified as mono, sesqui, di, tri and meroterpenoids and include isolated compounds and plants which exert activities mainly on GABAergic, glutamatergic, dopaminergic and opioid neurotransmitter systems.

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“…In spite of its wide use and the local experiences for cultivation (Burdyn et al, 2006) there were not studies about its gastrointestinal properties. Nevertheless, there were described anxiolytic and antidepressant effects of A. polystachya (Mora et al, 2005;Hellion-Ibarrola et al, 2008). Also, it has been described the presence of (-)-carvone in the essential oil of A. polystachya (Werdin-González et al, 2010), which was related to antispasmodic effect of Mentha genus (de Goncalves et al, 2008) as well as other terpenic compounds.…”

Section: Introductionmentioning

confidence: 99%

Antispasmodic effects of Aloysia polystachya and A. gratissima tinctures and extracts are due to non-competitive inhibition of intestinal contractility induced by acethylcholine and calcium

Consolini¹,

Berardi²,

Rosella³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The antispasmodic effects of acqueous extracts (AE) and tinctures (T) of Aloysia polystachya (Griseb.) Moldenke and Aloysia gratissima (Gillies & Hook.) Tronc., Verbenaceae, were studied on rat isolated ileum and duodenum. These plants are used for gastrointestinal disorders and as eupeptic in South America. Both AE non-competitively inhibited the dose-response curves (DRC) of ACh and the DRC of Ca 2+ in high-[K + ] o , as well as the T. The T of A. polystachya and A. gratissima respectively inhibited the ACh-DRC at the IC50 of 3.15±0.57 and 6.46±2.28 mg leaves/mL. The Ca 2+ -antagonist activity of both T occurred with IC50 respectively similar to those of the ACh-DRC, and was potentiated by the depolarization produced by 10 mM TEA, a blocker of K + -channels. The spasmolytic effect of T does not involve DA release and binding to D2, since it was not reduced by 10 µM metoclopramide. Also, T induced dose-dependent relaxation on the tonic contracture produced by high-[K + ] o and ACh. By TLC there were detected in the leaves the presence of carvone, and flavonoids such as quercetin and hesperidin. By HPLC there were not found vitexin nor isovitexin, identified in A. citriodora. The monoterpene (-)-carvone non-competitively inhibited the ACh-DRC (pD´2 of 4.0±0.1) and the DRC of Ca 2+ (pD´2 of 3.86±0.19), suggesting that the Ca 2+ -influx blockade is the mechanism of its antispasmodic effect. Results suggest that the antispasmodic effect of A. polystachya and A. gratissima are mostly explained by the non-competitive blockade of Ca +2 influx. It could be associated to the presence of flavonoids, and in the tinctures to some spasmolytic components of the essential oil such as carvone.

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Anxiolytic and antidepressant-like effects of the hydroalcoholic extract from Aloysia polystachya in rats

Cited by 71 publications

References 15 publications

Safety assessment and behavioral effects of Solanum guaraniticum leaf extract in rats

Safety assessment and behavioral effects of Solanum guaraniticum leaf extract in rats

Terpenóides com atividade sobre o Sistema Nervoso Central (SNC)

Antispasmodic effects of Aloysia polystachya and A. gratissima tinctures and extracts are due to non-competitive inhibition of intestinal contractility induced by acethylcholine and calcium

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