Anxiolytic and sedative activities of Passiflora edulis f. flavicarpa

Deng, Jun; Zhou, Yu-juan; Bai, Mengmeng; Li, Hongwei; Li, Li

doi:10.1016/j.jep.2009.12.043

Cited by 94 publications

(62 citation statements)

References 12 publications

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“…Flavones are important active constituents present in Passiflora species and appeared to have positive effects on anxiety through their capability to interact with GABAA receptors (Barbosa et al, 2008;Grundmann et al, 2008;Deng et al, 2010;Li et al, 2011). Flavone derivatives of apigenin were reported as anxiolytic agents in different studies using animal models of anxiety (Kumar & Sharma, 2006).…”

Section: Biological Activity-relationship Among Flavonoids Found In Smentioning

confidence: 99%

“…Flavone derivatives of apigenin were reported as anxiolytic agents in different studies using animal models of anxiety (Kumar & Sharma, 2006). Besides this, flavonoids with benzodiazepine receptors specificity and/or anxiolytic activity were obtained from medicinal plants that are traditionally used in folk medicine for their anxiolytic/ sedative properties, such as Turnera aphrodisiaca and Passiflora species (Grundmann et al, 2008;Deng et al, 2010;Li et al, 2011;Kumar & Sharma, 2006).…”

Section: Biological Activity-relationship Among Flavonoids Found In Smentioning

confidence: 99%

“…The anxiolytic activity of Passiflora species had been attributed to flavone derivatives of apigenin and luteolin (Grundmann et al, 2008;Deng et al, 2010;Li et al, 2011;Kumar & Sharma, 2006). S. guianensis showed a high content of flavonoids, such as, vicenin-2, quercetin-3,7-di-O-rhamnoside and kaempferol-3,7-di-O-rhamnoside, thus probably its medicinal use as anxiolytic could be attributed to these compounds.…”

Section: Biological Activity-relationship Among Flavonoids Found In Smentioning

confidence: 99%

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Chemical composition of hydroethanolic extracts from Siparuna guianensis, medicinal plant used as anxiolytics in Amazon region

Negri¹,

Santi²,

Tabach³

2012

Rev. bras. farmacogn.

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Siparuna guianensis Aubl., Siparunaceae, is used as anxiolytic plants in folk medicine by South-American indians, "caboclos" and river-dwellers. This work focused the evaluation of phenolic composition of hydroethanolic extract of S. guianensis through HPLC-DAD-ESI/MS/MS. The constituents exhibited protonated, deprotonated and sodiated molecules and the MS/MS fragmentation of protonated, deprotonated and sodiated molecules provided product ions with rich structural information. Vicenin-2 (apigenin-6,8-di-C-glucoside) was the main constituent found in S. guianensis together quercetin-3,7-di-O-rhamnoside and kaempferol-3,7-di-O-rhamnoside. A commercial extract of Passiflora incarnata (Phytomedicine) was used as surrogate standard and also was analyzed through HPLC-DAD-ESI/ MS/MS, showing flavones C-glycosides as constituents, among them, vicenin-2 and vitexin. The main constituent was vitexin. Flavonols triglycosides were also found in low content in S. guianensis and were tentatively characterized as quercetin-3-O-rutinoside-7-O-rhamnoside, quercetin-3-O-pentosyl-pentoside-7-O-rhamnoside and kaempferol-3-O-pentosyl-pentoside-7-O-rhamnoside. Apigenin and kaempferol derivatives had been reported as anxiolytic agents. Flavonoids present in this extract were correlated with flavonoids reported as anxiolytics.

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Section: Biological Activity-relationship Among Flavonoids Found In Smentioning

confidence: 99%

Section: Biological Activity-relationship Among Flavonoids Found In Smentioning

confidence: 99%

Section: Biological Activity-relationship Among Flavonoids Found In Smentioning

confidence: 99%

See 1 more Smart Citation

Chemical composition of hydroethanolic extracts from Siparuna guianensis, medicinal plant used as anxiolytics in Amazon region

Negri¹,

Santi²,

Tabach³

2012

Rev. bras. farmacogn.

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“…Tiliroside was isolated from Solanum crinitum Lam (Cornelius et al 2010). The effects of flavonoids as CNS active substances probably are related to the dose administered, because anxiolytic-like activity was observed at lower dose while sedative-like activity was observed at higher dose (Deng et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Plants from Solanaceae family with possible anxiolytic effect reported on 19th century's Brazilian medical journal

Giorgetti¹,

Negri²

2011

Rev. bras. farmacogn.

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Abstract:In the beginning of the 19 th century, the first Brazilian scientific knowledge journal on medicinal plants the Gazetas Médicas was launch reporting Brazilian medicinal plants belonging to several botanical families. The aim of this study was research the Solanaceae species that were described as anxiolytics in the 19 th century's Brazilian Medical Gazettes and to make a revision about these species in literature. A taxonomic update, together a careful research about ethnopharmacological, pharmacological and phytochemical, patent process and reports of phytomedicines, was carried out for these Solanaceae species. In this research were found thirteen plants, but the taxonomic update reduced this number to six species. Among them, Physalis angulata L. and Solanum nigrum L. were studied and showed depressor activity on central nervous system (CNS) as described in Gazetas Médicas. This research showed that Solanaceae species reported in this study has potential as anxiolytic drugs and should be investigated more deeply.

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“…Each mouse was monitored for 1 h. Data were expressed as number of movements (5-60 min) for 10 mice for each group. After each measurement, the locomotor-monitoring cages were carefully cleaned with wet tissue paper (10% ethanol solution) (Deng et al, 2010).…”

Section: Locomotor Activity Test In Micementioning

confidence: 99%

Sedative and anticonvulsant activities of styrax after oral and intranasal administration in mice

Guo

Duan

Tang

et al. 2011

Pharmaceutical Biology

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Anxiolytic and sedative activities of Passiflora edulis f. flavicarpa

Cited by 94 publications

References 12 publications

Chemical composition of hydroethanolic extracts from Siparuna guianensis, medicinal plant used as anxiolytics in Amazon region

Chemical composition of hydroethanolic extracts from Siparuna guianensis, medicinal plant used as anxiolytics in Amazon region

Plants from Solanaceae family with possible anxiolytic effect reported on 19th century's Brazilian medical journal

Sedative and anticonvulsant activities of styrax after oral and intranasal administration in mice

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