Anxiolytic Antidepressant and Anti-Inflammatory Activity of Ethanolic Extract of Urena Lobata Leaf

S, Sipai Babu; D, Bindu Madhuri; D, Subba Reddy

doi:10.21276/ijprhs.2016.04.07

Cited by 8 publications

(9 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…DFT is an important method for studying the theoretical chemical reactivity mechanisms of molecules. 6,11 According to Koopmans’ theory, the ionization potential (IP) and electron affinity (EA) are the eigenvalues of HOMO and LUMO energy levels. 11,12 Therefore, the IP and EA can be calculated through the following relations, respectively 13…”

Section: Theoretical Backgroundmentioning

confidence: 99%

“…Equation (1) is the basic equation for calculating different global chemical reactivity descriptors of the molecules like electronegativity ( χ ), chemical potential ( µ ), electrophilicity ( ω ), hardness ( η ), and softness ( S ). 11 The chemical potential and the hardness of the molecules are defined as the second derivatives of the energy with respect to the number of electrons ( N ). Equations (2) and (3) display the relationships…”

Section: Theoretical Backgroundmentioning

confidence: 99%

“…Finally, the nucleofugality (Δ E n ) and the electrofugality (Δ E e ) of the molecules can be discussed with respect to the nucleophilic and electrophilic capabilities of the leaving group in the molecules. 11,16 A good electrofuge with a high electrofugality will simultaneously dissociate from a substrate and donate an electron, leaving behind an electrophile. Conversely, a good nucleofuge with a high nucleofugality will readily accept an electron from a system, leaving behind a nucleophile.…”

Section: Theoretical Backgroundmentioning

confidence: 99%

See 2 more Smart Citations

Computational studies of the thermodynamic properties, and global and reactivity descriptors of fluorescein dye derivatives in acetonitrile using density functional theory

Juma

Vuai

2021

Journal of Chemical Research

View full text Add to dashboard Cite

This work reports density functional theory calculations of the optimized geometries, molecular reactivity, energy gap, and thermodynamic properties of molecular dyes fluorescein (FS), fluorescein attached with methoxy (FSO), fluorescein attached with amine (FSA), fluorescein attached with methane (FSM), fluorescein attached with ethene (FSE), and fluorescein attached with thiophene (FST) using the hybrid functional B3LYP and 6-311G basis sets. When donating groups are attached to the molecular dye, the bond lengths are slightly decreased which is important for easy transfer of electron from donating to the accepting group. For all dyes, highest occupied molecular orbital/lowest occupied molecular orbital analysis results in positive outcomes upon electron injection to semiconductors and subsequent dye regeneration by the electrolyte. The ionization potential increases with increasing conjugation; therefore, the molecular dye attached to thiophene has the highest ionization potential. Meanwhile, a donating group with increased conjugation results in low electron affinity.

show abstract

Section: Theoretical Backgroundmentioning

confidence: 99%

Section: Theoretical Backgroundmentioning

confidence: 99%

Section: Theoretical Backgroundmentioning

confidence: 99%

See 1 more Smart Citation

Computational studies of the thermodynamic properties, and global and reactivity descriptors of fluorescein dye derivatives in acetonitrile using density functional theory

Juma

Vuai

2021

Journal of Chemical Research

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

“…Chemical potential deals with the escaping tendency of electrons involved in a stable system [ 90 ]. It is reported that with decreasing chemical potential, the reactivity of species tends to increase [ 90 , 91 ]. Data reveals that hydroxychloroquine and oseltamivir display the largest and smallest value of chemical potential respectively.…”

Section: Resultsmentioning

confidence: 99%

A computational study of potential therapeutics for COVID-19 invoking conceptual density functional theory

et al. 2022

View full text Add to dashboard Cite

The pandemic, COVID-19, has caused social and economic disruption at a larger pace all over the world. Identification of an effective drug for the deadliest disease is still an exigency. One of the most promising approaches to combat the lethal disease is use of repurposed drugs. This study provides insights into some of the potential repurposed drugs viz. camostat mesylate, hydroxychloroquine, nitazoxanide, and oseltamivir in terms of the computational quantum chemical method. Properties of these compounds have been elucidated in terms of Conceptual Density Functional Theory (CDFT)-based descriptors, IR spectra, and thermochemical properties. Computed results specify that hydroxychloroquine is the most reactive drug among them. Thermochemical data reveals that camostat mesylate has the utmost heat capacity, entropy, and thermal energy. Our findings indicate that camostat mesylate and hydroxychloroquine may be investigated further as potential COVID-19 therapeutics. We anticipate that the current study will aid the scientific community to design and develop viable therapeutics against COVID-19.

show abstract

Assessment of <i>In vitro</i> antioxidant and Analgesic activity of Ethyl acetate fraction of <i>Urena Lobata</i> leaves

B. Shelke,

Navale,

Patel

et al. 2024

JNR

View full text Add to dashboard Cite

Background: The primary aim of this study is to identify the most active fraction from Urena lobata leaves and subsequently evaluate the analgesic and antioxidant accomplishments of the identified potent extract. The focus is on determining the fraction with the highest efficacy for potential therapeutic applications. Methods: U. lobata leaves were consecutively extracted with solvents like n-hexane, chloroform, ethyl acetate, and methanol. The concentrated fractions underwent initial phytochemical screening. The fraction exhibiting the highest activity, as determined by the carrageenan model, was further evaluated for its analgesic potential through the hot plate and acetic acid-induced writhing methods. In-vitro antioxidant activity was evaluated through DPPH and FRAP assays. Results: The preliminary phytochemical analysis of U. lobata leaf fractions exposed the presence of steroids, triterpenes, alkaloids, carbohydrates, tannins, and flavonoids. In the carrageenan-induced hind paw edema model, the ethyl acetate fraction of U. lobata leaf (ULEAF) demonstrated the highest anti-inflammatory effects, comparable to the standard drug Diclofenac sodium. Evaluation of analgesic potential using the hot-plate method and acetic acid-induced writhing test showed dose-dependent efficacy, with 500 mg/kg ULEAF exhibiting effects similar to ibuprofen. In vitro, antioxidant assays indicated potent radical scavenging and reducing power in the ethyl acetate fraction. Conclusion: In conclusion, U. lobata leaf fractions exhibited potent anti-inflammatory properties, with the ethyl acetate fraction demonstrating notable analgesic and antioxidant activity. These findings support the plant’s therapeutic potential for further exploration in pharmaceutical development.

show abstract

Anxiolytic Antidepressant and Anti-Inflammatory Activity of Ethanolic Extract of Urena Lobata Leaf

Cited by 8 publications

References 16 publications

Computational studies of the thermodynamic properties, and global and reactivity descriptors of fluorescein dye derivatives in acetonitrile using density functional theory

Computational studies of the thermodynamic properties, and global and reactivity descriptors of fluorescein dye derivatives in acetonitrile using density functional theory

A computational study of potential therapeutics for COVID-19 invoking conceptual density functional theory

Assessment of <i>In vitro</i> antioxidant and Analgesic activity of Ethyl acetate fraction of <i>Urena Lobata</i> leaves

Contact Info

Product

Resources

About