Anxiolytic effect of estradiol in the median raphe nucleus mediated by 5-HT1A receptors

Andrade, Telma Gonçalves Carneiro Spera de; Nakamuta, Juliana Sanajotti; Avanzi, V.; Graeff, Frederico Guilherme

doi:10.1016/j.bbr.2005.04.015

Cited by 42 publications

(28 citation statements)

References 69 publications

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“…For example, the anorectic effects of fenfluramine are enhanced during the estrous phase of the female rat reproductive cycle [23]. Further, there is a precedent in the literature for interactions between the 5-HT 1A receptor and estrogen in measures relevant to moos such as the production of receptive sexual behavior [24] and also antidepressant [25] and anxiolytic [26] effects. In the present experiments sucrose intakes were averaged across the 4-6 day reproductive cycle of mice [17] and thus estrus cycle was not monitored.…”

Section: Discussionmentioning

confidence: 99%

Sucrose intake and fasting glucose levels in 5-HT1A and 5-HT1B receptor mutant mice

Bechtholt

Smith

Gaughan

et al. 2008

Physiology & Behavior

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Serotonin (5-HT) 1A and 5-HT 1B receptors have been implicated in the incidence and treatment of depression in part through the examination of animals lacking these receptors. Although these receptors have been repeatedly implicated in ingestive behavior there is little information about how 5-HT 1A and 5-HT 1B receptor mutant mice react to solutions of varying palatability. In the present experiment male and female 5-HT 1A and 5-HT 1B mutant and wild-type mice were presented with increasing concentrations of sucrose using a two-bottle choice procedure. In addition fasting blood glucose levels were assessed. Both male and female 5-HT 1B mutant mice drank more sucrose than WT mice but also consumed more water. Female, but not male, 5-HT 1A mutant mice similarly showed increased sucrose consumption, but did not demonstrate increased consumption of water. In addition, the pattern of increased sucrose consumption over genotype and sex was related to fasting blood glucose concentrations such that levels in male 5-HT 1B mutant mice were reduced relative to wild-type and 5-HT 1A mutant males, but similar to those of females. The findings in 5-HT 1B mutant mice emphasize the role of the 5-HT 1B receptor in regulating ingestive behavior, whereas female sex hormones and 5-HT 1A receptors may interact to alter sucrose consumption in 5-HT 1A mutant mice. In addition, these findings may have implications for the role of these receptors in the incidence and treatment of depression since the intake of sucrose has been used as an index of anhedonia in animal models of depression and antidepressant efficacy.

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Section: Discussionmentioning

confidence: 99%

Sucrose intake and fasting glucose levels in 5-HT1A and 5-HT1B receptor mutant mice

Bechtholt

Smith

Gaughan

et al. 2008

Physiology & Behavior

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“…Second, although the hippocampus and VMH are logical areas to begin investigating the brain region-and ER subtype-specific effects of E 2 for anxiety, and socio-sexual behavior, it is likely that these are not the only brain regions involved in the behavioral effects observed. For instance, direct E 2 administration to the medial amygdala or median raphe nucleus decreases anxiety and depressive behavior of ovx rats demonstrating that these brain regions are sensitive to E 2 's effects and involved in affective responses (Walf and Frye, 2003;Andrade et al, 2005;Walf and Frye, 2006). Indeed, in the case of the amygdala, ERa and ERb expression varies with reproductive status and mating stimuli (Greco et al, 2003a, b).…”

Section: Discussionmentioning

confidence: 99%

Antisense Oligodeoxynucleotides for Estrogen Receptor-β and α Attenuate Estradiol's Modulation of Affective and Sexual Behavior, Respectively

Walf

Ciriza

Garcia-Segura

et al. 2007

Neuropsychopharmacol

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Estradiol (E 2 ) modulates affective and socio-sexual behavior of female rodents. E 2 's functional effects may involve actions through a and b isoforms of estrogen receptor (ERs). The importance of E 2 's actions at these isoforms for anxiety (open field, elevated plus maze), depression (forced swim test), and sexual behavior (lordosis) was investigated using an antisense oligonucleotide (AS-ODN) strategy. If ERb is required for anti-anxiety and antidepressant-like effects, and ERa is required for sexual receptivity, of E 2 , then intracerebroventricular administration of AS-ODNs against these ERs should attenuate these effects and reduce immunoreactivity of ERs in brain regions that mediate these behaviors, such as the hippocampus and ventral medial hypothalamus (VMH). Ovariectomized rats were primed with 17b-E 2 (10 mg) 48 h before testing (hour 0). At hours 0, 24, and 47.5, rats were infused with saline vehicle, scrambled control AS-ODNs, or AS-ODNs targeted against ERa and/or ERb, and were tested at hour 48. Rats infused with ERb AS-ODNs, alone, or with ERa AS-ODNs had significantly decreased open field central entries, decreased plus maze open arm time and entries, increased time spent immobile, and decreased time spent swimming in the forced swim test, and decreased ERb immunoreactivity in the brain than did rats administered ERa AS-ODNs, vehicle, or scrambled AS-ODNs. Rats that were administered ERa AS-ODNs, alone, or with ERb AS-ODNs had significantly decreased lordosis and decreased ERa immunoreactivity in the brain compared to rats administered ERb AS-ODNs, vehicle, or scrambled AS-ODNs. Thus, ERb and ERa may be required for E 2 's modulation of affective and sexual behavior, respectively.

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“…The cyclic fluctuations of oestrogens enhance the response to stress, which confers susceptibility to depression and anxiety (Seeman 1997). Shiroma et al (2005) and Andrade et al (2005) supposed that a reduction in E2 could be related to the development or exacerbations of anxiety or depression or other psychic disorders such as schizophrenia (Rao and Kolsch 2003;Huber et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Exposure to traffic pollutants and effects on 17-β-estradiol (E2) in female workers

Tomei

Ciarrocca

Fortunato

et al. 2006

Int Arch Occup Environ Health

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Considering that the potential confounding effect of extraneous factors was controlled for by restricting the study population and by matching traffic police and controls on the above-mentioned variables, our results suggest that occupational exposure to urban pollutants, EDs included, might alter E2 plasma concentrations. E2 could be used in occupational set as an early biomarker of exposure to urban pollutants, valuable for the group, even before the onset of the related pathologies (adverse pregnancy outcome and mental health disorders).

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Anxiolytic effect of estradiol in the median raphe nucleus mediated by 5-HT1A receptors

Cited by 42 publications

References 69 publications

Sucrose intake and fasting glucose levels in 5-HT1A and 5-HT1B receptor mutant mice

Sucrose intake and fasting glucose levels in 5-HT1A and 5-HT1B receptor mutant mice

Antisense Oligodeoxynucleotides for Estrogen Receptor-β and α Attenuate Estradiol's Modulation of Affective and Sexual Behavior, Respectively

Exposure to traffic pollutants and effects on 17-β-estradiol (E2) in female workers

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