Anxiolytic-like and sedative effects of Kyllinga brevifolia in mice

Hellión-Ibarrola, María del Carmen; Montalbetti, Y.; Heinichen, O.; Kennedy, María L.; Campuzano, M.; Ibarrola, D.A.

doi:10.1590/s0102-695x2012005000112

Cited by 8 publications

(4 citation statements)

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“…Such is the case of Valeriana officinalis, whose roots, rhizomes, and stolons have sesquiterpenes and iridoids such as valerenone, valerianol, valerenic acid among others, which have shown some GABAergic activity, reducing anxiety levels 6 ; Passiflora incarnata, whose aerial parts contain flavonoids and alkaloids to which the sedative and anxiolytic effects are attributed 7 , among others. In our research group, we have previously investigated the anxiolytic-like effect of Kyllinga brevifolia rhizomes 8 ; and Aloysia polystachya leaves extract 9 , and both demonstrated the ability to reduce anxiety and also antidepressant like effect [10][11][12] .…”

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confidence: 99%

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2021

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Anxiety disorders are among the most prevalent and high-cost diseases. Medicinal plants are a very good option to treat, and several have shown the ability to reduce anxiety. We report here the effect of A. gratissima var. gratissima (Agg) on behavior and anxiety in mice. The methanol extract of leaves was tested in order to verify the safety, effect on sleeping time and behavior. Anxiety was tested through the Open field, Hole board, and elevated plus maze tests, with 50, 100, 200, and 400 mg/kg of Agg, and diazepam as positive control drugs. The results showed that A. gratissima var. gratissima did not cause signs of toxicity or sedative effect, and the general behavior of mice was not altered with any dose. All doses of Agg and diazepam, after the mice were submitted to the Open field and Hole board, evidenced a significant increase in ambulation, and a significant decrease in immobility time, related to the control group. On Hole board, a significant increase in number and time spent in exploration indicated a possible anxiolytic-like effect, that was confirmed by the results obtained in the elevated plus-maze, where mice increased the number of entries and time spent in open arms, and decreased the number of entries and time spent in closed arms of the labyrinth. Al the results evidenced the safety of Agg, and denoted an anxiolytic-like effect in mice. INTRODUCTION:Anxiety disorders, affecting up to 33.7% of the population, are the most prevalent mental disorders and are associated with a high cost in health. A substantial underrecognition and under-treatment of these disorders have been demonstrated 1 . Persistent fretfulness, distractedness, and a sort of whole-body clenching to a full-blown panic attack constitute the variety of clinical manifestations of anxiety, which are indicators of a possible threat to homeostasis.

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2021

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“…We have previously reported that Kyllinga brevifolia, stimulate intestinal transit, increases sleeping time induced by barbiturate and exert an anxiolytic-like activity in mice [11,12].…”

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confidence: 98%

“…Kyllinga brevifolia Rottb. (Cyperaceae) (Cyperus brevifolius (Rottb) Hassk) (kapi-i katí) leaves and rhizomes are used in Paraguayan traditional medicine as sedative and tonic, as well as carminative and digestive among others [8][9][10].We have previously investigated the effect of K. brevifolia rhizomes on intestinal transit, sleeping time induced by barbiturate, acute toxicity [11], and the anxiolytic-like effect in mice [12]. Previous researches revealed the presence of flavonoids on K. brevifolia rhizomes [13].…”

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confidence: 99%

Evaluation of Anti-Aggressive Activity of Kyllinga brevifolia in Rodent Model of Aggression

Hellión-Ibarrola

Kennedy

Campuzano

et al. 2014

J. Adv. Clin. Pharmacol

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Kyllinga brevifolia Rottb, Cyperaceae, rhizomes are used in the Paraguayan folk medicine as sedative and tonic for nervous system. The aim of this study was to determine the anti-aggressive activity of hydro-ethanolic (rhizomes) extract (CEKb), hexane (KbF-hex), chloroform (KbF-chlo), ethyl acetate (KbF-ethyl-ac) and aqueous (KbF-aq) fractions of K. brevifolia on the aggressive behavior assessed in the isolation-induced aggression model in male mice. The effect on aggressive behavior was observed during a ten minute resident-intruder confrontation. Oral doses of CEKb (10 and 100 mg/kg; p< 0.05), KbF-hex (0.1, p<0.01; 1, p<0.001 and 10 mg/kg, p< 0.01)) and KbF-ethyl-ac (0.1, p<0.01; 1, p< 0.05 and 10 mg/kg, p< 0.05) from K. brevifolia reduced fighting time of isolation-induced aggressive behavior, respectively, in male mice. In conclusion, our results make evident that CEKb, Hex Kb and KbF-ethyl-ac obtained from K. brevifolia possesses anti aggressive-like property in mice. These finding give further support to the traditional use of Kyllinga brevifolia as sedative and tonic in Paraguayan folk medicine. Taken together, these findings suggest that Kyllinga brevifolia exhibits a general anti-offensive aggressive activity and may be relevant in the treatment of reactive aggression in humans.

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“…This group was considered a positive depressant control as validation of the method. The time in minutes between the injection of the hypnotic and the loss of the posture reflex (induction time) and the time for the spontaneous recovery of the reflex (sleep time) of each animal were recorded [20][21][22] .…”

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confidence: 99%

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2023

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Begonia cucullata Willd. (Begoniaceae) is a native medicinal species from Paraguay popularly used to combat stomatitis, pharyngitis, respiratory ailments in children, and inflammatory conditions among others. The limited literature did not report these plants as having analgesic, anti-inflammatory, or antimicrobial properties. This work aims to determine the acute toxicity, general behavior, analgesic, and anti-inflammatory activities in mice and antimicrobial activity in-vitro of crude extract of B. cucullata (CEBc). Experimental induced-pain models (Randall-Selitto, Writhing, and Hot plate test) were used for the study of analgesia in mice. Likewise, carrageenan-induced paw edema was used to evaluate the antiedematous activity of CEBc. CEBc is safe, well-tolerated, and without behavioral effects in mice and is devoid of antibacterial activity. Using the Randall-Selitto method, oral doses of CEBc denoted a significant increment in the pain threshold up to 260 %. Also, in the writhing test, the number of abdominal contortions was significantly decreased up to 68% by CEBc in a dose-dependent manner in comparison to the control group. Likewise, oral administration of CEBc in mice presented a 160% increase in latency periods in the hot plate test. Moreover, a 63% reduction in carrageenan-induced paw edema was observed with CEBc treatment. Finally, the presence of alkaloids, tannins, steroids, and/or triterpenes was identified in the CEBc. Based on the results, it is concluded that CEBc has significant analgesic and anti-inflammatory capacity in mice treated orally. These experimental results correlate with popular use in Paraguay and have huge potential for innovation and development. INTRODUCTION:The major risk for human beings' survival requires the appropriate perception QUICK RESPONSE CODE

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Anxiolytic-like and sedative effects of Kyllinga brevifolia in mice

Cited by 8 publications

References 20 publications

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Evaluation of Anti-Aggressive Activity of Kyllinga brevifolia in Rodent Model of Aggression

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