Anxiolytic-like effect of hydroalcoholic extract of ripe pistachio hulls in adult female Wistar rats and its possible mechanisms

Rostampour, Mohammad; Hadipour, Elham; Oryan, S; Soltani, Bahram Mohammad; Saadat, Farshid

doi:10.4103/1735-5362.194870

Cited by 7 publications

(5 citation statements)

References 26 publications

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“…Moreover, the AChE inhibitory activity of its fruit hull methanol extract was proven in another study by a percentage of 5.5 % in enzyme inhibition [35]. The anxiolytic effect of the hydroalcoholic extract of its hull (10 mg/kg) has been shown in female rats, which might be concluded due to the role of GABA and estrogen receptors in its antianxiety effect [36].…”

Section: Pistacia Veramentioning

confidence: 92%

Pistacia Genus as a Potential Source of Neuroprotective Natural Products

et al. 2019

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Neuroprotective agents are able to defend the central nervous system against acute or chronic neuronal injuries. Even with the progress made over the last decades, most of the medications prescribed for the management of neurodegenerative diseases can only reduce their symptoms and slow down their progression. Based on natural product research, there are potential effective medicinal plants and phytochemicals for modulating neuronal functions and protecting against neurodegeneration. Plants in the genus Pistacia are also among valuable natural resources for neuroprotection research based on experiences in traditional medicine. Studies have supported the value of bioactive compounds of the genus Pistacia for central nervous system disorders such as Alzheimerʼs, Parkinsonʼs, multiple sclerosis, cerebral ischemia, depression, and anxiety. Related literature has also revealed that most of the evidence on neuroprotection in the genus Pistacia is in the form of preliminary studies, mainly including models of behavior, motor function, and memory impairments in animals, neural toxicity, cerebral ischemia and seizure models, evaluation of their effects on antioxidant and inflammatory biomarkers, amyloid β aggregation, and acetylcholinesterase as well as investigations into some cellular pathways. Along with the phytonutrients in kernels such as pistachios, various phytochemicals, mostly terpenes, and phenolic compounds have also been identified in different plant parts, in particular their oleoresins, of species in the genus Pistacia. In this review, the pharmacology of neurological effects and related molecular mechanisms of the plants belonging to the genus Pistacia and its active constituents, as well as pharmacokinetics aspects, are discussed.

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Section: Pistacia Veramentioning

confidence: 92%

Pistacia Genus as a Potential Source of Neuroprotective Natural Products

et al. 2019

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“…Commercially available extracts ( Table 1 ) were selected based on the following references reporting beneficial properties of plants in reducing sleep disorders and anxiety: for Ex1 , and Ex6 ( Melissa officinalis ); Ex2 , and Ex5 ( Passiflora incarnata ); Ex4 ( Crocus sativus ); Ex3 , and Ex7 ( Eschscholzia californica ), Ex9 ( Hypericum perforatum ), Ex12 ( Humulus lupulus ), Ex13 ( Withania somnifera ), Ex19 ( Rhodiola rosea ); Ex24 , and Ex25 ( Valeriana offinalis ) see [ 23 , 24 ]; for Ex12 , Ex24 , and Ex25 see [ 25 ]; for Ex14 ( Withania somnifera ) see [ 26 ]; for Ex18 ( Pistacia vera ) see [ 27 ]; and for Ex23 ( Verbena officinalis ) see [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

Pistacia vera Extract Potentiates the Effect of Melatonin on Human Melatonin MT1 and MT2 Receptors with Functional Selectivity

Labani,

Gbahou,

Noblet

et al. 2023

Pharmaceutics

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Melatonin is a tryptophan derivative synthesized in plants and animals. In humans, melatonin acts on melatonin MT1 and MT2 receptors belonging to the G protein-coupled receptor (GPCR) family. Synthetic melatonin receptor agonists are prescribed for insomnia and depressive and circadian-related disorders. Here, we tested 25 commercial plant extracts, reported to have beneficial properties in sleep disorders and anxiety, using cellular assays (2─[125I]iodomelatonin binding, cAMP inhibition, ERK1/2 activation and β-arrestin2 recruitment) in mock-transfected and HEK293 cells expressing MT1 or MT2. Various melatonin receptor-dependent and -independent effects were observed. Extract 18 (Ex18) from Pistacia vera dried fruits stood out with very potent effects in melatonin receptor expressing cells. The high content of endogenous melatonin in Ex18 (5.28 ± 0.46 mg/g extract) is consistent with this observation. Ex18 contains an additional active principle that potentiates the effect of melatonin on Gi protein-dependent pathways but not on β-arrestin2 recruitment. Further active principles potentiating exogenous melatonin were detected in several extracts. In conclusion, we identified plant extracts with various effects in GPCR-based binding and signalling assays and identified high melatonin levels and a melatonin-potentiating activity in Pistacia vera dried fruit extracts that might be of therapeutic potential.

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“…Pistachios and pistachio extracts appear to play further roles in cognitive function, inducing neurobehavioral and neurochemical modifications [117,118] and exerting anxiolytic (anti-anxiety) effects [119,120]. Pistachio consumption also been linked to restoration of gut microbiota composition, with improved Bifidobacterium, Lactobacillus, Turicibacter and Romboutsia (beneficial bacteria) profiles [121,122].…”

Section: Other Potential Benefitsmentioning

confidence: 99%

Believe It or ‘Nut’: Why It Is Time to Set the Record Straight on Nut Protein Quality: Pistachio (Pistacia vera L.) Focus

Derbyshire

Higgs²,

Feeney³

et al. 2023

Nutrients

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There are growing public health movements to transition towards diets that are plant-based. However, confusion exists with concerns that plant-based proteins (including nuts) may be inferior with respect to protein quality. The present publication evaluates the evolution of protein quality concepts and explains the protein science related to pistachios. Pistachio nuts are a plant-based complete protein providing all nine EAAs in addition to an array of nutrients and phytochemicals. They have a PDCAAS of 73 and 81%, (raw and roasted pistachios, respectively), higher than that of many other tree nuts. From an environmental perspective transitioning towards plant-based diets (including nuts) could have potential to reduce total/green water footprints. Dietary guidelines are evolving yet nuts such as pistachios do not always have a clear place within these. Now appears to be a pertinent time to look at protein quality from the perspective of whole daily diets and dietary patterns, factoring in both health and environmental outcomes. Given updated modes of thinking, nuts such as pistachios have an important role to play in terms of providing ready-to-eat, good-quality, plant-based protein within daily diets.

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Anxiolytic-like effect of hydroalcoholic extract of ripe pistachio hulls in adult female Wistar rats and its possible mechanisms

Cited by 7 publications

References 26 publications

Pistacia Genus as a Potential Source of Neuroprotective Natural Products

Pistacia Genus as a Potential Source of Neuroprotective Natural Products

Pistacia vera Extract Potentiates the Effect of Melatonin on Human Melatonin MT1 and MT2 Receptors with Functional Selectivity

Believe It or ‘Nut’: Why It Is Time to Set the Record Straight on Nut Protein Quality: Pistachio (Pistacia vera L.) Focus

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