Anxiolytic-like effect of the aqueous extract of Justicia spicigera leaves on female rats: A comparison to diazepam

García-Ríos, Rosa Isela; Mora-Pérez, A.; González-Torres, Daniel; Carpio-Reyes, Ricardo de Jesús; Soria-Fregozo, César

doi:10.1016/j.phymed.2018.07.007

Cited by 17 publications

(7 citation statements)

References 18 publications

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“…In the present study, none of the treatments affected the closed-arm entries in the EPM or the motor activity in the LAT (i.e., crossings, rearing, and grooming), thus demonstrating the specificity of anxiolytic-like effects in dioestrus and anxiogenic-like effects in proestrus when chrysin and allopregnanolone were microinjected into the hippocampus. These effects are consistent with those in previous studies that reported no significant effects of anxiolytic drugs, the ovarian cycle, or stereotactic surgery on locomotor activity ( Rodríguez-Landa et al, 2009 , 2013 , 2019 ; Carro-Juárez et al, 2012 ; Hernández-López et al, 2017 ; García-Ríos et al, 2019 ). On the other hand, intraperitoneal injections of chrysin (2 mg/kg) in dioestrus rats increased grooming behaviour in the LAT ( Rodríguez-Landa et al, 2021 ).…”

Section: Discussionsupporting

confidence: 92%

“…At the preclinical level, anxiety-like behaviour is higher during metoestrus-dioestrus, characterised by low concentrations of steroid hormones than proestrus-oestrus which, in contrast, presents high hormonal concentrations ( Marcondes et al, 2001 ). This naturally occurring anxiety-like behaviour prompted the evaluation of substances that relieve anxiety associated with metestrus-dioestrus ( Ravenelle et al, 2018 ; García-Ríos et al, 2019 ; Rodríguez-Landa et al, 2021 ), which is a physiological state similar to the premenstrual period in women ( Lovick, 2008 ). In this way, some flavonoids exert anxiolytic-like effects in rodents.…”

Section: Introductionmentioning

confidence: 99%

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GABAA/Benzodiazepine Receptor Complex in the Dorsal Hippocampus Mediates the Effects of Chrysin on Anxiety-Like Behaviour in Female Rats

Rodríguez‐Landa

Hernández-López

Martı́nez-Mota

et al. 2022

Front. Behav. Neurosci.

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Systemic injections of the flavonoid chrysin (5,7-dihydroxyflavone) exert anxiolytic-like effects in ovariectomised and cycling female rats through actions on gamma-aminobutyric acid-A (GABAA) receptors; however, it is unknown if chrysin directly acts on brain structures that are involved in regulating emotional processes, such as the hippocampus. The present study evaluated the effects of intrahippocampal microinjections of 0.25, 0.5, and 1 μg of chrysin on anxiety-like behaviour in the elevated plus maze (EPM) and locomotor activity test (LAT) in female rats in proestrus and dioestrus. Similar doses of the neurosteroid allopregnanolone were used as a reference GABAergic anxiolytic drug. The participation of the GABAA/benzodiazepine receptor complex was evaluated by administering the antagonists picrotoxin, bicuculline and flumazenil. In proestrus, 0.5 and 1 μg of chrysin and allopregnanolone induced anxiogenic-like behaviour. In dioestrus, chrysin, and allopregnanolone (0.5 μg) induced anxiolytic-like effects. Picrotoxin, bicuculline and flumazenil prevented the effects of chrysin and allopregnanolone in both proestrus and dioestrus. None of the treatments significantly affected locomotor activity. These results indicate that the GABAA/benzodiazepine receptor complex in the dorsal hippocampus regulates the effects of chrysin on anxiety-like behaviour, similar to the actions of allopregnanolone. The divergent effects of treatments across the oestrous cycle phases suggest complex interactions between GABAA receptors and compounds with an anxiolytic potential.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

GABAA/Benzodiazepine Receptor Complex in the Dorsal Hippocampus Mediates the Effects of Chrysin on Anxiety-Like Behaviour in Female Rats

Rodríguez‐Landa

Hernández-López

Martı́nez-Mota

et al. 2022

Front. Behav. Neurosci.

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“…Furthermore, its properties have been used since pre-Hispanic times to obtain indigo dye for paintm food, baskets, crafts and clothes. Concerning its ethnopharmacology, preclinical assays have demonstrated the anticonvulsant properties induced by aqueous extracts of J. spicigera and its derivate kaempferitrin [ 165 ], as well as antidepressant [ 166 ] and anxiolytic-like effects [ 167 ]. In the same way, the antidiabetic, [ 168 ] antitumor, immunomodulatory [ 169 ], anti-inflammatory [ 136 ] and antiparasitic [ 170 ] properties of this plant have been demonstrated.…”

Section: Preclinical Studies Of Mexican Medicinal Plants Used In Inflammatory and Neuropathic Pain Treatmentmentioning

confidence: 99%

Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment—A Review

Quiñonez-Bastidas

Navarrete

2021

Plants

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Despite the availability of many anti-pain drugs, in the form of NSAIDs, steroids, gabapentinoids, opioids, and antidepressants, in this study we address the natural compounds belonging to the group of Mexican medicinal plants or “Mexican folk medicine”, used for pain management in Mexico. Our interest in this subject is due to the growing idea that “natural is harmless” and to the large number of side effects exhibited in pharmacotherapy. The objective of this review was to document the scientific evidence about Mexican medicinal plants and their derivatives used for inflammatory and neuropathic pain treatment, as well as the mechanisms of action implicated in their antinociceptive effects, their possible adverse effects, and the main pharmacological aspects of each plant or compound. Our data review suggested that most studies on Mexican medicinal plants have used inflammatory experimental models for testing. The anti-pain properties exerted by medicinal plants lack adverse effects, and their toxicological assays report that they are safe to consume; therefore, more studies should be performed on preclinical neuropathic pain models. Moreover, there is no convincing evidence about the possible mechanisms of action involved in the anti-pain properties exerted by Mexican plants. Therefore, the isolation and pharmacological characterization of these plant derivatives’ compounds will be important in the design of future preclinical studies.

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“…Resumo: Este projeto de pesquisa avaliou o percentual de rendimento da extração etanólica das plantas medicinais alegria (Scutellaria incarnata) e chambá ( Justicia pectoralis) ao aplicar dois métodos de maceração com ou sem agitação, com o material vegetal inteiro ou moído, além da realização de testes com diferentes tempos de maceração (6,12,24, 48 e 92 horas), até alcançar a estabilização da extração. A análise dos dados foi baseada em um modelo de análise estatística correspondente para determinar os valores estatísticos mais relevantes no processo de extração, com base no fator tempo, no método usado e no tamanho das partículas.…”

Section: Coleta E Rendimento Do Extrato Etanólico De Duas Plantas Medicinaisunclassified

Obtención y rendimiento del extracto etanólico de dos plantas medicinales

Benítez-Benítez

Sarria-Villa

Corredor

et al. 2020

Rev. Fac. Cienc. Básicas

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En el presente trabajo de investigación se evaluó el porcentaje de rendimiento de la extracción etanólica de las plantas medicinales Alegría (Scutellaria incarnata) y Amansatoros (Justicia pectoralis), al aplicar dos métodos de maceración con y sin agitación, con el material vegetal entero y molido, además de realizarse pruebas en diferentes tiempos de maceración (6, 12, 24, 48 y 92 horas) hasta llegar a la estabilización de la extracción. Para el análisis de los datos se empleó un modelo de análisis estadístico correspondiente a un diseño experimental en bloques completos al azar con arreglo factorial (Anova), con el fin de determinar los valores estadísticos más relevantes en el proceso de extracción, de acuerdo con el factor tiempo, el método empleado y el tamaño de partícula. Tanto para la planta Alegría como para Amansatoros los resultados indican que, en la obtención del extracto etanólico, el mejor tiempo fue de 48 horas, con el uso de material molido y la aplicación de agitación. Estas condiciones permitieron obtener rendimientos del 37.000 y 37.600% para el extracto etanólico de Amansatoros y Alegría, respectivamente.

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Anxiolytic-like effect of the aqueous extract of Justicia spicigera leaves on female rats: A comparison to diazepam

Cited by 17 publications

References 18 publications

GABAA/Benzodiazepine Receptor Complex in the Dorsal Hippocampus Mediates the Effects of Chrysin on Anxiety-Like Behaviour in Female Rats

GABAA/Benzodiazepine Receptor Complex in the Dorsal Hippocampus Mediates the Effects of Chrysin on Anxiety-Like Behaviour in Female Rats

Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment—A Review

Obtención y rendimiento del extracto etanólico de dos plantas medicinales

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