Anxiolytic-like effects of inhaled linalool oxide in experimental mouse anxiety models

Souto-Maior, Flávia Negromonte; Carvalho, Fabíola Lélis de; Morais, Liana Clébia Soares Lima de; Netto, Sueli Mendonça; Sousa, Damião Pergentino de; Almeida, Reinaldo Nóbrega de

doi:10.1016/j.pbb.2011.08.029

Cited by 104 publications

(63 citation statements)

References 39 publications

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“…In our study, the Rosa canina extract noticeably decreased the level of anxiety in rats. It should be mentioned that linalool inhalation was also shown to reduce anxiety [33]. As was reported, linalool prevents glutamate (i.e., the main excitatory neurotransmitter) from binding to its receptors in the rat neocortex [34].…”

Section: Discussionmentioning

confidence: 84%

Effect of a Hydroalcoholic Extract of Rosa Canina Flowers on Anxiety in Rats

et al. 2015

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We investigated effects of the hydroalcoholic extract of Rosa сanina (dog rose) petals on behavior of rats in the elevated plus-maze (EPM) test; adult male Wistar rats weighing 200-240 g were used. Oral everyday administration of the Rosa extract in three doses (150, 300, and 450 mg/kg) was done for one week. Animal behavior in the EPM was videotaped for 10 min, and conventional indices considered to be related to the anxiety level were scored. Introduction of the Rosa canina extract significantly increased the number of open arm entries in a dose-dependent manner and also increased the time of stay in the open arms at a high dose (450 mg/kg). At the same time, the number of closed arm entries interpreted as a correlate of the locomotion intensity did not differ from the control at all doses. Thus, the Rosa canina extract, when orally administered, demonstrates an anxiolytic profile in rats. Future investigations are essential for better understanding of the anxiolytic properties of the extract and neurobiological mechanisms of its action (probable interactions of the Rose extract active agents with neurotransmitter systems.

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Section: Discussionmentioning

confidence: 84%

Effect of a Hydroalcoholic Extract of Rosa Canina Flowers on Anxiety in Rats

et al. 2015

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“…In the present study, OB extract decreased the level of anxiety in animals. In connection to this finding, an effect of linalool inhalation has been shown to reduce anxiety (58). Also, it has been reported that linalool prevents glutamate (the main excitatory neurotransmitter) from binding to its receptors in the neocortex of rats (59).…”

Section: Discussionmentioning

confidence: 88%

Anxiolytic Effect of Ocimum basilicum Extract in Rats Tested by Elevated Plus-Maze Task

Nemati

Oveisi

Komaki‬

et al. 2015

Avicenna J Neuro Psych Physio

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Background: There are reports in traditional medicine about the effectiveness of Ocimum basilicum (OB) in the treatment of anxiety. The Elevated Plus-Maze (EPM) has been predominantly used to investigate anxiety levels in rodents. Objectives: The purpose of the present study was to investigate the effectiveness of extract of OB on rat behavior in the EPM test. Materials and Methods: Male Wistar rats weighing 220 -250 g were used in the present study. Forty rats were divided into 4 groups: three OB groups (25, 50, 100 mg/kg oral administration of OB for 7 days) and a saline control group. One day after the last day of feeding, the animals' behavior in EPM was videotaped for 10 minutes. Then, their behavior scored for formal indexes of anxiety, such as the total distance covered by animals, the percentage of entries into and the time spent in open and closed arms. Results:The results showed that after oral feeding of OB, the percentage of open arms entry and open arms time in EPM increased in the experimental groups. OB extract has no effect on the total distance covered by animals and number of closed arm entries. Conclusions: Our results demonstrated that the extract of OB could induce anxiolytic effect in rats after 1 week oral administration. The effect of OB was not induced through changes in motor activity. Further investigations are necessary for pharmacological providing of OB and better understanding of its anxiolytic properties and neurobiological mechanisms.

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“…Despite the availability of treatment with several anxiolytic drugs currently on the market, many of these pharmaceutical options, such as benzodiazepines, are fairly nonselective and may cause significant adverse effects such as dependence, tolerance, withdrawal syndrome or muscle relaxation (Souto-Maior et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Anxiolytic-like effect of Citrus limon (L.) Burm f. essential oil inhalation on mice

Viana

Cardoso

Silva

et al. 2016

Rev. bras. plantas med.

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Experimental in vivo study aimed to characterize the anxiolytic-like effect of the Citrus limon fruit peel's essential oil (CLEO) in animal models of anxiety, besides evaluating the viability J774.A1 cells in vitro through the MTT reduction method at the concentrations of 10 and 100 µg/mL. The anxiolytic behavior was evaluated in Swiss mice (n = 8) using the methodology of Elevated Plus-Maze (EPM) and Open-Field (OF). CLEO was tested by inhalation at the doses of 100, 200, and 400 µL, and as control, animals were subjected to inhalation of the vehicle (saline solution 0.9% + Tween80®) and intraperitoneal administration of diazepam (1.5 mg/kg). In the cell viability assay, it was observed that none of the concentrations showed cytotoxicity. OF test showed significant anxiolytic activity at all tested doses of OECL, compared to the control group, without changing the motor performance of the animals. Corroborating OF data, the EPM test confirmed anxiolytic activity in at least two doses of the tested oil (200 and 400 µL), justified by the number of entries and increase in the percentage of time in the open arms. The data analysis of this study evidenced that inhalation of OECL was able to induce an anxiolytic behavior in mice; however, further studies are required to ensure its safe use by the population. .A1 através do método de redução do MTT nas concentrações de 10 e 100 µg/mL. O comportamento ansiolítico foi avaliado em camundongos Swiss (n = 8), utilizando a metodologia do Labirinto em Cruz Elevado (LCE) e do Campo Aberto (CA). O OECL foi testado por inalação nas doses de 100, 200 e 400 µL, e como controle, os grupos foram submetidos à inalação do veículo (Solução fisiológica 0,9% + Tween80®) e administração intraperitoneal de diazepam (1,5 mg/kg). No ensaio de viabilidade celular, observou-se que nenhuma das concentrações apresentou citotoxicidade. O teste de CA demonstrou atividade ansiolítica significativa em todas as doses testadas do OECL, comparada ao grupo controle, sem alterar a performance motora dos animais. Corroborando os dados do CA, o teste do LCE confirmou a atividade ansiolítica em pelo menos duas das doses do óleo testadas (200 e 400 µL), justificada pelo número de entradas e aumento na percentagem de tempo nos braços abertos. A análise dos dados deste estudo evidenciou que a inalação do OECL foi capaz de induzir um comportamento ansiolítico em camundongos; entretanto, outros estudos são necessários para garantir o seu uso seguro pela população.Palavras-chave: Ansiolítico. Citrus limon. Óleo essencial. Inalação. Camundongos.

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Anxiolytic-like effects of inhaled linalool oxide in experimental mouse anxiety models

Cited by 104 publications

References 39 publications

Effect of a Hydroalcoholic Extract of Rosa Canina Flowers on Anxiety in Rats

Effect of a Hydroalcoholic Extract of Rosa Canina Flowers on Anxiety in Rats

Anxiolytic Effect of Ocimum basilicum Extract in Rats Tested by Elevated Plus-Maze Task

Anxiolytic-like effect of Citrus limon (L.) Burm f. essential oil inhalation on mice

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