Anxiolytic-Like Effects of (O-Methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin III) from Aniba riparia (NEES) MEZ (Lauraceae) in Mice

Melo, Cristina Carvalho de; Monteiro, Andreisa Paiva; Leite, Caroline Porto; Araújo, Fernando Luiz Oliveira de; Lima, Vera Targino Moreira; Barbosa-Filho, José Maria; Fonteles, Marta Maria de França; Vasconcelos, Silvânia Maria Mendes; Viana, Glauce Socorro de Barros; Sousa, F.C.F.

doi:10.1248/bpb.29.451

Cited by 50 publications

(31 citation statements)

References 30 publications

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“…It is well known that benzodiazepines act as anxiolytics (at low doses), anticonvulsants, and also produce sedation and a myorelaxant effect at higher doses. Thereby, our research group has used diazepam at 0.75 mg/kg in open field and in elevated plus maze tests and screening for antipyretic effects, as standard drug (Melo et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Chemical composition and anxiolytic-like effects of the Bauhinia platypetala

Santos¹,

Lima²,

Cerqueira³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The pantropical genus Bauhinia, Fabaceae, known popularly as cow's foot, is widely used in folk medicine as antidiabetic. Behavioral effects of the ethanolic extract and ethereal, aqueous and ethyl acetate fractions from B. platypetala Benth. ex Hemsl. leaves were studied in male Swiss mice. The ethanolic extract and fractions were administered intraperitoneally and its effects on spontaneous motor activity (total motility, locomotion, rearing and grooming behavior) were monitored. Anxiolytic-like properties were studied in the elevated plus-maze test and the possible antidepressantlike actions were evaluated in the forced swimming test. The results revealed that only the highest dose of the ethereal fraction (50 mg/kg, i.p.) caused a signifi cant decrease in total motility, locomotion and rearing. Sole dose injected (50 mg/kg) of ethanolic extract and ethereal fractions increased the exploration of the elevated plus-maze open arms in a similar way to that of diazepam (2 mg/kg, i.p.). In the forced swimming test, the ethanolic extract and their fractions (12.5, 25 or 50 mg/kg) was not as effective as paroxetine (10 or 20 mg/kg, i.p.) and imipramine (25 or 50 mg/kg, i.p.) in reducing immobility. These results suggest that some of the components of the ethanolic extract and of the ethereal fraction from B. platypetala, such as p-cymene, phytol, D-lactic acid, hexadecanoic acid, among others, may have anxiolytic-like properties, which deserve further investigation. Furthermore, the results obtained indicate that ethanolic extract from B. platypetala and their fractions do not present antidepressive properties. However, these properties cannot be related to the chemical constituents identifi ed in this specie.

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Section: Discussionmentioning

confidence: 99%

Chemical composition and anxiolytic-like effects of the Bauhinia platypetala

Santos¹,

Lima²,

Cerqueira³

et al. 2012

Rev. bras. farmacogn.

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“…In this study, the effects of CFAZ, the major alkaloid fraction extracted from ZSS were performed in animal models of anxiety, such as elevated plus-maze, hole-board test, open field teat, locomotor activity and grip strength meter, which are classical models for screening central nervous system actions providing in formation about anxiety, myo-relaxant activity and depression (Silva et al, 2007;de Melo et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Anxiolytic-Like Effects of Cyclopeptide Fraction Alkaloids of Zizyphi Spinosi Semen: Possible Involvement of GABA_AReceptors

Han¹,

An²,

Eun³

et al. 2008

Biomolecules and Therapeutics

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However, CFAZ has no effect on the locomotor activity, while diazepam (2.0 mg/kg, p.o.) significantly reduced locomotor activity. CFAZ did not influence the grip force in the grip strength meter test, either. From the molecular experiments, CFAZ increased chloride influx in cultured cerebellar granule cells. In addition, GABA A receptors γ-subunit were over-expressed by CFAZ in cultured cerebellar granule cells. It is concluded that CFAZ may have anxiolytic-like effects, and these effects may be mediated by GABA A receptors.

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“…The rats received saline, diazepam (1 mg/kg) (19) or sibutramine (10 mg/kg) (20) intraperitoneally in a volume of 1 mL/kg. Diazepam was used as a positive control for the anxiolytic effect.…”

Section: Drugs and Treatment Proceduresmentioning

confidence: 99%

Absence of sibutramine effect on spontaneous anxiety in rats

Frassetto

Alves

Santos

et al. 2010

Arq Bras Endocrinol Metab

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Introduction: Sibutramine has been described as a drug recommended for treatment of obesity, since it has the ability to inhibit the reuptake of serotonin and noradrenaline in the central nervous system, thereby increasing energy expenditure. Objective: Investigate the anxiogenic and anxiolytic effects of acute and chronic treatment with sibutramine in rats submitted to the task of the elevated plus-maze. Methods: Diazepam was used as a positive control for the anxiolytic effect, and the task of the elevated plus-maze showed sensitivity to detect the effect. In the chronic treatment, sibutramine was ingested for a period of two months. Results: The acute and chronic treatments at the studied dose, which is described to produce a maximum effect of anti-obesity in rats, did not interfere with anxiety. Conclusions: The acute and chronic administration of sibutramine is not related to anxiolytic or anxiogenic effects. Arq Bras Endocrinol Metab. 2010;54(4):375-80

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Anxiolytic-Like Effects of (O-Methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin III) from Aniba riparia (NEES) MEZ (Lauraceae) in Mice

Cited by 50 publications

References 30 publications

Chemical composition and anxiolytic-like effects of the Bauhinia platypetala

Chemical composition and anxiolytic-like effects of the Bauhinia platypetala

Anxiolytic-Like Effects of Cyclopeptide Fraction Alkaloids of Zizyphi Spinosi Semen: Possible Involvement of GABA_AReceptors

Absence of sibutramine effect on spontaneous anxiety in rats

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Anxiolytic-Like Effects of (O-Methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin III) from Aniba riparia (NEES) MEZ (Lauraceae) in Mice

Cited by 50 publications

References 30 publications

Chemical composition and anxiolytic-like effects of the Bauhinia platypetala

Chemical composition and anxiolytic-like effects of the Bauhinia platypetala

Anxiolytic-Like Effects of Cyclopeptide Fraction Alkaloids of Zizyphi Spinosi Semen: Possible Involvement of GABAAReceptors

Absence of sibutramine effect on spontaneous anxiety in rats

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Anxiolytic-Like Effects of Cyclopeptide Fraction Alkaloids of Zizyphi Spinosi Semen: Possible Involvement of GABA_AReceptors