Anxiolytic-like effects of phytol: Possible involvement of GABAergic transmission

Costa, Jéssica Pereira; Ga, de Oliveira; Aa, de Almeida; Islam, Muhammad Torequl; Dp, de Sousa; Rm, de Freitas

doi:10.1016/j.brainres.2013.12.003

Cited by 84 publications

(71 citation statements)

References 40 publications

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“…It was reported that phytol exhibits anticonvulsant activity by modulating of neurotransmitter systems in piloacarpine-induced seizures and showed antitubercular activity against M. tuberculosis H37Rv strain at 100 mg mL -1 (MIC) [9,10]. Acute administration of phytol exerts an anxiolytic-like effect on mice by producing sedative and anxiolytic activities [11]. Phytol also directly activates peroxisome proliferator-activated receptor α (PPARα) and regulated gene expression involved in lipid metabolism in PPARα-expressing HepG2 hepatocytes [12].…”

Section: Discussionmentioning

confidence: 99%

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Gas Chromatographic-Mass Spectrometric Analysis of Essential Oil of <i>Jasminum officinale</i> L var Grandiflorum Flower

Wei¹,

Fl²,

Tan³

2015

Trop. J. Pharm Res

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Section: Discussionmentioning

confidence: 99%

“…grandifloroum L. (Jasminum grandiflorum) by gas chromatography-mass spectrometry (GC-MS 3,7,11,3,7,6,7,11,. …”

mentioning

confidence: 99%

Gas Chromatographic-Mass Spectrometric Analysis of Essential Oil of <i>Jasminum officinale</i> L var Grandiflorum Flower

Wei¹,

Fl²,

Tan³

2015

Trop. J. Pharm Res

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show abstract

“…[95], antidepressant [96] and anxiolytic (25, 50, 75 mg/kg; i.p.) activities [15], PYT is now proven to have neuropharmacological potentials. In addition, there been a suggestion for its possible GABA-receptor mediated action, although the exact mechanism should be found out [9,15].…”

Section: Pyt With Neuropharmacological Activitiesmentioning

confidence: 99%

“…activities [15], PYT is now proven to have neuropharmacological potentials. In addition, there been a suggestion for its possible GABA-receptor mediated action, although the exact mechanism should be found out [9,15]. In addition, PYT has also been previously reported to have antispasmodic activity [4].…”

Section: Pyt With Neuropharmacological Activitiesmentioning

confidence: 99%

“…An evidence suggests that PYT has antibiotic-chemotherapeutic [5] activity. It is well known that body produces numerous oxidation mediators like e ROS, RNS which causes various diseases [155e158] including neurological maladies [9,10,15,96]. In addition, deficiency and mutation as well as inactivation of superoxide dismutases (SOD) (important antioxidative defense enzymes) may lead cellular inflammation [159], neural disorders [160e163] likee Down's syndrome [164], hepato-cellular carcinoma [165] and perinatal lethality [166]; while catalase (CAT), the other essential antioxidative defense enzyme has been linked to develop IDDM in association with ROS mediated cellular malfunctions [167,168].…”

Section: Class(code) Stands For A61kmentioning

confidence: 99%

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Phytol in a pharma-medico-stance

Islam

Alencar

Machado

et al. 2015

Chemico-Biological Interactions

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Antidepressant‐ and Anxiolytic‐Like Effect of the Froriepia subpinnata Extract in the Rat: Neurochemical Correlates

Samandari‐Bahraseman,

Esmaeilzadeh‐Salestani,

Dogani

et al. 2024

Brain and Behavior

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BackgroundThe study aims to explore the potential antianxiety effect of Froriepia subpinnata, a native plant in northern Iran, and it is considered an antiflatulent, appetizing, antiseptic, antispasmodic, and diuretic. Despite its widespread use in diets and its reputation for calming effects, no prior research has specifically investigated its antianxiety properties.MethodsRats were subjected to a variety of stressors for 24 days. Rats were treated with the F. subpinnata extract (100, 200, and 400 mg/kg, orally) for 14 days starting from the 10th day of stress. Then behavioral tests (elevated plus‐maze, open field, sucrose preference, Morris water maze, passive avoidance) were examined. Real‐time PCR was used to investigate changes in the expression of candidate genes of stress response and memory. Oxidative stress markers and corticosterone levels in serum were also measured.ResultsChronic stress reduced performance in a variety of tests of anxiety and memory, and treatment with the F. subpinnata extract dose‐dependently improved the behavioral deficits caused by chronic stress. At the dose of 200 mg/kg, the F. subpinnata extract mitigated the effect of stress on the expression of several genes, such as those encoding dopamine D1 and D2 receptors, glutamate NMDA, and AMPA receptor subunits (Grin1 and Gria1, respectively), glucocorticoid and mineralocorticoid receptors, cholecystokinin (CCK) and CCKB receptor, neuropeptide Y, and the GABAA receptor alpha2 subunit. Also, the expression of two genes, TrkB and BDNF, was significantly affected by the extract, demonstrating meaningful decreasing changes. Furthermore, treatment with the extract led to a decrease in oxidative stress and an elevation in cortisol levels in stressed animals.ConclusionIn this study, we provide the first evidence of the antistress and antianxiety effects of F. subpinnata extract, along with its potential procognitive impact on memory.

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Anxiolytic-like effects of phytol: Possible involvement of GABAergic transmission

Cited by 84 publications

References 40 publications

Gas Chromatographic-Mass Spectrometric Analysis of Essential Oil of <i>Jasminum officinale</i> L var Grandiflorum Flower

Gas Chromatographic-Mass Spectrometric Analysis of Essential Oil of <i>Jasminum officinale</i> L var Grandiflorum Flower

Phytol in a pharma-medico-stance

Antidepressant‐ and Anxiolytic‐Like Effect of the Froriepia subpinnata Extract in the Rat: Neurochemical Correlates

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