Anxiolytic-like effects of sanjoinine A isolated from Zizyphi Spinosi Semen: Possible involvement of GABAergic transmission

Han, Huishan; Ma, Yi; Eun, Jae Soon; Li, RiHua; Jiang, Hong; Lee, Myung-Koo; Oh, Ki‐Wan

doi:10.1016/j.pbb.2008.11.012

Cited by 92 publications

(60 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Additionally, in recent years, several studies have shown that jujube is protective against cancer, inflammation, allergy, and diabetes (Goyal et al 2011;Lee et al 2012). The traditional therapeutic effect of sour jujube is for treatment of insomnia and anxiety, as well as for pain-relieving and anticonvulsant (Guo et al 2011;Han et al 2009;Ma et al 2008). As for functional components, they include alkaloids (sanjoinine A), flavonoids, saponins (jujubosides), and fatty acids (Cao et al 2010;Ma et al 2008;Zhao et al 2006a).…”

mentioning

confidence: 99%

Functional components in Zizyphus with emphasis on polysaccharides

Kao

Chen

2014

Polysaccharides

View full text Add to dashboard Cite

Zizyphus jujuba (Chinese jujube), mainly distributed in the subtropical regions of Asia, has been cultivated for over 4,000 years and used as food, food additive, flavor, as well as traditional Chinese herb, as it possesses analeptic, palliative, and antibechic functions. The fruit of jujube is quite popular due to high nutritional value and presence of many functional components, in which polysaccharide is the most important one. Polysaccharides, being essential constituents of all living organisms, are naturally occurring polymers of aldoses and ketoses linked together through glycosidic linkages. In recent years, polysaccharides of plant origin have emerged as a vital class of bioactive nature products; however, there is a lack of information regarding analysis and biological activity of jujube polysaccharides. Moreover, the composition of polysaccharides in jujube may vary with different species, growth environment, cultivar variety, and extraction and separation methods, which in turn may affect the overall biological activity. The objective of this manuscript is to review the current status associated with jujube polysaccharide, including nutritional and functional components; methods of extraction, purification, separation, identification, and quantitation; as well as biological activity.

show abstract

mentioning

confidence: 99%

Functional components in Zizyphus with emphasis on polysaccharides

Kao

Chen

2014

Polysaccharides

View full text Add to dashboard Cite

show abstract

“…Diazepam exhibited its established anxiolytic effects by significantly increasing the time spent and entries in the open arms of the maze. Increase in the proportion of time spent and entries into the open arms of the maze indicates reduction of anxiety (17). In a highly comparable manner, the CJ extract (100 and 200 mg/kg) significantly increased time spent and entries into the open arms of the maze.…”

Section: Discussionmentioning

confidence: 84%

“…In addition, diazepam significantly increased exploratory time at the unprotected center zone (q = 2.84, p < 0.05). This increase in exploration in the center area was thought to reflect the anxiolytic property of diazepam (17). Similarly, the CJ extract showed a significant increase in exploratory activity in the center area of the open-field test at doses of 100 (q = 2.75, p < 0.05) and 200 (q = 2.78, p < 0.05) mg/kg.…”

Section: Discussionmentioning

confidence: 90%

The ethanol extract of Cirsium japonicum increased chloride ion influx through stimulating GABAA receptor in human neuroblastoma cells and exhibited anxiolytic-like effects in mice

et al. 2013

View full text Add to dashboard Cite

To further characterize the anxiolytic activities of CJ, its action on human neuroblastoma cells were assessed. The CJ extract dose-dependently increased chloride ion (Cl -) influx, which was blocked by coadministration of the GABA A receptor competitive antagonist, bicuculline, suggesting a GABA A receptor -Cl -channel mechanism of action. Taken altogether, the present study demonstrates that the ethanol extract of CJ has anxiolytic effects, probably mediated through GABAergic neurotransmission.

show abstract

“…(Han et al, 2009), and RGE may work through a similar mechanism. Here, RGE ameliorated behavioral evidence of anxiety, consistent with ginseng's anti-stress effects, as well as its ability to module hypothalamus-pituitary-adrenal axis function and decrease corticosterone levels in blood (Kim et al, 2003;Navarrete et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Anti-Stress Effects of Ginsenoside Rg₃-Standardized Ginseng Extract in Restraint Stressed Animals

Kim¹,

Jo²,

Park³

et al. 2010

Biomolecules and Therapeutics

Self Cite

View full text Add to dashboard Cite

-We tested whether ginsenosides Rg3-standardized ginseng extract (RGE) has anti-stress effects in restraint-stressed animals. RGE increased time spent in the open arms and open arm entries in the elevated plus-maze test. In addition, RGE blocked the reduction of center zone distance and stereotypes behaviors in the open-field test. RGE also increased head dips in stressed mice, indicating anxiolytic-like effects. Stress decreased movement distance and duration, burrowing, and rearing frequency but increased face washing and grooming. RGE significantly reversed burrowing and rearing activity in stressed mice. In addition, we measured sleep architecture in restraint stressed rats using EEG recorder. Stress increased rapid eye movement (REM) sleep, but total sleep and non-rapid eye movement (NREM) sleep were not changed. RGE did not affect sleep architecture in stressed rats. These behavioral experiments suggest that RGE has anti-stress effects in restraint-stressed animal models.

show abstract

Anxiolytic-like effects of sanjoinine A isolated from Zizyphi Spinosi Semen: Possible involvement of GABAergic transmission

Cited by 92 publications

References 42 publications

Functional components in Zizyphus with emphasis on polysaccharides

Functional components in Zizyphus with emphasis on polysaccharides

The ethanol extract of Cirsium japonicum increased chloride ion influx through stimulating GABAA receptor in human neuroblastoma cells and exhibited anxiolytic-like effects in mice

Anti-Stress Effects of Ginsenoside Rg₃-Standardized Ginseng Extract in Restraint Stressed Animals

Contact Info

Product

Resources

About

Anxiolytic-like effects of sanjoinine A isolated from Zizyphi Spinosi Semen: Possible involvement of GABAergic transmission

Cited by 92 publications

References 42 publications

Functional components in Zizyphus with emphasis on polysaccharides

Functional components in Zizyphus with emphasis on polysaccharides

The ethanol extract of Cirsium japonicum increased chloride ion influx through stimulating GABAA receptor in human neuroblastoma cells and exhibited anxiolytic-like effects in mice

Anti-Stress Effects of Ginsenoside Rg3-Standardized Ginseng Extract in Restraint Stressed Animals

Contact Info

Product

Resources

About

Anti-Stress Effects of Ginsenoside Rg₃-Standardized Ginseng Extract in Restraint Stressed Animals