Anxiolytic-like effects of sinapic acid in mice

Ethyl Cinnamate Derivatives as Promising High-Efficient Acaricides against <i>Psoroptes cuniculi</i>: Synthesis, Bioactivity and Structure–Activity Relationship

“…In the past decades, cinnamic acid derivatives including natural, semi-synthetic and synthetic compounds had been proven to have a variety of pharmacological activities, 13) such as anticancer, 14,15) antimicrobial, [16][17][18] antioxidative, 18) anti-inflammatory, 15,[19][20][21] anti-Mycobactrium tuberculosis, [22][23][24] antiviral, 25) anti-human immunodeficiency virus (HIV), [26][27][28] antidiabetic, 29) anticholesterolemic, 30) analgesic, 31) hepatoprotective, 32,33) immunoprotective, 34) inducing neural progenitor cell proliferation 35) and anxiolytic activity. 36) Especially, what interests us is that cinnamic acid derivatives also have significant antiparasitic activities on plasmodia, 37) Leishmania 38) and nematode. 39) Furthermore, the acaricidal activity of ethyl cinnamate 40) and trans-cinnamaldehyde 41) as an analogue of cinnamic acid were reported as well.…”

Effect of fermentation with Monascus pilosus on the antioxidant activities and phenolic acid contents of adzuki bean (Vigna angularis)

“…Sinapic acid is one of the most common hydroxycinnamic acids and it has been proposed as a potent antioxidant [50]. In recent years many researches have revealed that sinapic acid has anti-inflammatory, anticancer, and anti-anxiety activities [51][52][53]. Ferulic acid shows a wide range of therapeutic effects in the treatment of cancer, lung and cardiovascular diseases, antimicrobial and anti-inflammatory activities with its strong free radical scavenging capacities [54].…”

Therapeutic potentials of Brassica juncea: an overview

“…Anxiolytic activity, antioxidant, Cognitionimproving activity Yoon et al, 2007;Karakida et al, 2007;Zou et al, 2002. 4.…”

“…Interestingly, in more recent years, a few reports indicating central nervous system (CNS) function modulating effects of some known secondary metabolites of the plants have started appearing. Some of them dealt with sinapic and other phenolic acids (Yoon et al, 2007) known for a long period to be abundantly present in Brassica juncea. One of these reports (Yoon et al, 2007) reveals that low oral doses (4 mg/kg) of pure synapic acid possess strong anxiolytic activities in animal models and that this effect is due to its modulating effects on neuronal GABA-gated chloride channel functions.…”

“…Some of them dealt with sinapic and other phenolic acids (Yoon et al, 2007) known for a long period to be abundantly present in Brassica juncea. One of these reports (Yoon et al, 2007) reveals that low oral doses (4 mg/kg) of pure synapic acid possess strong anxiolytic activities in animal models and that this effect is due to its modulating effects on neuronal GABA-gated chloride channel functions. A recent review (Sharma, 2001) summarizes numerous bioactivities, including CNS function modulating effects, of these and numerous other phenolic acid present in Brassica juncea and in diverse types of extracts obtainable from its different parts.…”