Anxiolytic Natural and Synthetic Flavonoid Ligands of the Central Benzodiazepine Receptor Have No Effect on Memory Tasks in Rats

Salgueiro, Jennifer Braathen; Ardenghi, Patrícia Grolli; Dias, Marcelo Fernandes Pacheco; Ferreira, Maria Beatriz Cardoso; Izquierdo, Iván; Medina, Jorge H.

doi:10.1016/s0091-3057(97)00054-3

Cited by 113 publications

(71 citation statements)

References 13 publications

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“…With respect to their therapeutic importance as anxiolytic and sedative-like compounds, it has been demonstrated that flavonoids such as quercetin, rutin and kaempferol elicit Central Nervous System activity involving the inhibitory GABAergic system. 18,26,27 As described, rutin was the other abundant flavonoid detected in the active extract; it is known that plants increase glycosylated aglicone production as a mechanism to avoid damage. 28 This property of plants is also an advantage in folk medicine, since they can be used as tranquilizers, among other therapeutic properties.…”

Section: Discussionmentioning

confidence: 89%

Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

Aguirre-Hernández

González-Trujano

Terrazas

et al. 2016

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Section: Discussionmentioning

confidence: 89%

Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

Aguirre-Hernández

González-Trujano

Terrazas

et al. 2016

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“…It has been well reported in literature that flavonoids and phenolics enhance GABA neurotransmission and GABA is the main inhibitory neurotransmitter which is suppressed in epilepsy [40]. Thus, the suppression of seizures by MES dose-dependently might be attributed to phenolics reach composition of the extract through enhancing GABA neurotransmission in brain or by blockade of glutamatergic neurotransmission mediated by the NMDA receptor.…”

Section: Discussionmentioning

confidence: 96%

Anticonvulsant and Antioxidant Effects of Methanol Extract of Stems of <i>G. arborea Roxb.</i>

Acharya¹,

Acharya²,

Kumar³

et al. 2015

JNR

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Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.

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“…However, if apigenin decreased the GABA-activated Cl Ϫ currents, apigenin should exhibit an anxiogenic effect, but Viola et al and Salgueiro et al reported that apigenin exhibits anxiolytic activity in mice without any sedative or myorelaxant effects. 13,33) Thus, there are discrepancies in reporting the ability of apigenin to GABA activity.…”

Section: Discussionmentioning

confidence: 99%

“…NE Turnover There was a significant difference in the MHPG/NE ratio between 4 groups in the amygdala [F (3,33) Post-hoc analysis revealed that the forced swim test exposure produced a significant increase in the MHPG/NE ratio in the amygdala (pϽ0.01), frontal cortex (pϽ0.05), hypothalamus (pϽ0.01), and midbrain (pϽ0.05) (Fig. 8).…”

Section: -Ht Turnovermentioning

confidence: 99%

Antidepressant-Like Effects of Apigenin and 2,4,5-Trimethoxycinnamic Acid from Perilla frutescens in the Forced Swimming Test.

Nakazawa

Yasuda

Ueda

et al. 2003

Biological & Pharmaceutical Bulletin

138

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The leaves of Perilla frutescens BRITTON var. acuta KUDO (Labiatae) are found in Hangekoubokuto, Saibokuto, and other traditional Chinese herbal remedies which are primarily used to treat inflammatory diseases, clinical depression, and anxiety-related disorders such as anxiety neurosis and anxiety hysteria. [1][2][3][4] One of the goals in our laboratory is to characterize the bioactive compounds of Perilla frutescens. Although many components such as essential oils, 5,6) flavones, 7-9) and phenylpropanoids 10,11) have been identified in Perilla frutescens, to our knowledge, the bioactive compounds for the traditional use of the herbal medicine are still unidentified.In most cases, traditional medicines are prepared by extraction with hot water and are orally administered so that the components present in the aqueous extract may be metabolized by gut flora before being absorbed into the body. Accordingly, to evaluate the bioactive compounds in the herbal medicines, investigation of the compounds actually absorbed into the body is necessary. In a preliminary work, we reported that apigenin and 2,4,5-trimethoxycinnamic acid (TMCA) (Fig. 1) were detected in the plasma and urine when an aqueous extract of P. frutescens was administered to humans. 12) Moreover, it has been reported that apigenin possesses a variety of pharmacological actions on the central nervous system, such as anxiolytic and sedative properties, [13][14][15] while to our knowledge, the effect of TMCA is not well characterized.The purpose of the present study was to examine the effect of treatment with apigenin and TMCA on immobility in the forced swimming test, which has been a useful experimental method for screening antidepressant activity, as a wide range of antidepressants, including tricyclics, monoamine oxidase inhibitors, atypicals, by reducing the duration of immobility. 16,17) Moreover, in addition to the behavioral change in the forced swimming test, the levels of norepinephrine (NE), dopamine (DA), 5-hydroxytriptamine (5-HT), and their metabolites in the striatum, hippocampus, amygdala, frontal cortex, thalamus, hypothalamus, and midbrain were used as parameters for evaluating antidepressant activity of apigenin and TMCA, and the effect of dopaminergic blockade on the anti-immobility action of apigenin in the forced swimming test was also investigated. MATERIALS AND METHODS AnimalsMale ddY mice (Japan SLC, Inc.) weighting 26-30 g were used for all the experimental. Animals were housed 5 per cage in a temperature (22Ϯ2°C), humidity (55Ϯ10%), and light (8:00-20:00) controlled room with free access to distilled water and commercial rodent chow (CE-2, Clea Japan Inc., Tokyo). All Experiments were carried out between 14:00 and 17:00 h and performed according to the Guide for Care and Use of Laboratory Animals at Tohoku Pharmaceutical University.Drugs Apigenin (Funakoshi Co., Ltd., Tokyo, Japan), TMCA (Tokyo Chemical Industry Co., Ltd., Tokyo, Japan), and haloperidol (Wako Pure Chemical Industries, Ltd., Tokyo, Japan) were uniformly dispersed...

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Anxiolytic Natural and Synthetic Flavonoid Ligands of the Central Benzodiazepine Receptor Have No Effect on Memory Tasks in Rats

Cited by 113 publications

References 13 publications

Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

Anxiolytic and sedative-like effects of flavonoids from Tilia americana var. mexicana: GABAergic and serotonergic participation

Anticonvulsant and Antioxidant Effects of Methanol Extract of Stems of <i>G. arborea Roxb.</i>

Antidepressant-Like Effects of Apigenin and 2,4,5-Trimethoxycinnamic Acid from Perilla frutescens in the Forced Swimming Test.

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