Any Future for Faecal Microbiota Transplantation as a Novel Strategy for Gut Microbiota Modulation in Human and Veterinary Medicine?

Takáčová, Martina; Bomba, Alojz; Tóthová, Csilla; Micháľová, Alena; Turňa, Hana

doi:10.3390/life12050723

Cited by 14 publications

(12 citation statements)

References 216 publications

(341 reference statements)

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“…Recently, research on the modulation of the gut microbiota has focused on fecal microbiota transplantation (FMT), which refers to a method of transfer of feces from a healthy individual to the gut of a diseased recipient via an enema, endoscopy, nasogastric tube, or by indigestion peroral capsules ( Takáčová et al, 2022 ). It is considered an innovative, effective, and safe technique to treat challenging diseases like Clostridium difficile ( Bárcena et al, 2019 ), Campylobacter jejuni ( Brooks et al, 2017 ; Heimesaat et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Fecal microbiota transplantation from Suncus murinus, an obesity-resistant animal, to C57BL/6NCrSIc mice, and the antibiotic effects in the approach

et al. 2023

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IntroductionImportant studies on the relationship of the intestinal microbial flora with obesity have uncovered profound changes in the composition of the gut microbiota in obese individuals. Animal studies successfully altered body phenotypes by fecal microbiota transplantation (FMT).MethodsIn this study, we analyzed the gut microbiome of Suncus murinus (S. murinus), a naturally obesity-resistant animal, and the changes of the gut flora of C57BL/6NCrSIc mice that received gut bacteria transplantation from S. murinus by 16S rRNA gene analysis method. And analyzed and discussed the possible impact of the use of antibiotics before transplantation on the outcome of transplantation.ResultsOur results showed no significant changes in body weight in the FMT group compared to the control (AB) group, but large fluctuations due to antibiotics. There was no change in blood lipid levels between groups before and after FMT. The gut microbiota of S. murinus were enriched in Firmicutes and Proteobacteria, while Bacteroidetes were not detected, and fewer OTUs were detected in the intestine gut in comparison to other mouse groups. Statistically significant differences in alpha diversity were observed between the FMT group and other groups. Furthermore, a beta diversity analysis indicated an apparent structural separation between the FMT group and other groups.ConclusionIt was suggested that the gut flora of S. murinus was not well established in the gut trace of mice through FMT, and the administration of antibiotics before transplantation was an important factor affecting the overall composition of the gut flora. Although FMT of S. murinus failed to completely colonize the intestinal tract of the mice, it still had a certain effect on the establishment of the intestinal flora of the mice. The unpredictable effects of pre-transplantation antibiotics on the results of transplantation cannot be ignored.

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Section: Introductionmentioning

confidence: 99%

Fecal microbiota transplantation from Suncus murinus, an obesity-resistant animal, to C57BL/6NCrSIc mice, and the antibiotic effects in the approach

et al. 2023

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“…Personalized and targeted modulation of gut microbiota has all the prerequisites to become a key strategy for the prevention and supportive therapy of chronic diseases. [44,45]. Personalized and precision medicine creates prerequisites for the application of new methods of treatment for many chronic diseases aimed at modifying the gut microbiome, including cancer therapy.…”

Section: Personalized and Targeted Microbiota Modulation And Its Pote...mentioning

confidence: 99%

Personalized and Targeted Gut Microbiome Modulation in the Prevention and Treatment of Chronic Diseases

Bomba¹,

Haranta²

2024

Advances in Probiotics for Health and Nutrition

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The gut microbiota is being recognized as a factor with a significant influence on host physiology, health maintenance, and disease prevention. Distinct alterations of the gut microbiota are correlated with several chronic diseases. Currently, gut microbiota can be modulated by diet, probiotics, prebiotics, postbiotics, pharmabiotics, and fecal microbiota transplantation. An effective strategy in gut microbiota modulation is needed for the prevention and supportive treatment of chronic diseases. New and more effective approaches toward gut microbiota modulation are emerging, namely personalization and targeted modulation. The composition of novel products and treatments based on the individual gut microbiome, metabolome, strain specificity, and clinical data analysis can reveal and address specific changes to the diversity, composition, and function of gut microbiota. These analyses enable the development of personalized and targeted gut microbiota modulation, by the application of beneficial microorganisms, their consortia, their metabolites, and their effective combination.

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“…Postbiotics refer to dead microorganisms or microbial metabolic products beneficial to gut health [ 91 ]. Although postbiotics do not include live microorganisms, they may have beneficial properties based on their pleiotropic effects, including anti-inflammatory, antioxidant, immunomodulatory and anticancer properties [ 92 , 93 ]. After an exhaustive review of the literature, we found no study investigating the use of a product with only postbiotic properties in dogs with CIEs.…”

Section: Limitations and Reconsideration Of The Current Classificationmentioning

confidence: 99%

Updating the Classification of Chronic Inflammatory Enteropathies in Dogs

Dupouy-Manescau,

Méric,

Sénécat

et al. 2024

Animals

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Chronic inflammatory enteropathies (CIEs) in dogs are currently classified based on response to sequential treatment trials into food-responsive (FREs); antibiotic-responsive (AREs); immunosuppressant-responsive (IREs); and non-responsive enteropathies (NREs). Recent studies have reported that a proportion of NRE dogs ultimately respond to further dietary trials and are subsequently misclassified. The FRE subset among CIEs is therefore probably underestimated. Moreover, alterations in the gut microbiota composition and function (dysbiosis) have been shown to be involved in CIE pathogenesis in recent research on dogs. Metronidazole and other antibiotics that have been used for decades for dogs with AREs have been demonstrated to result in increased antimicrobial resistance and deleterious effects on the gut microbiota. As a consequence, the clinical approach to CIEs has evolved in recent years toward the gradual abandonment of the use of antibiotics and their replacement by other treatments with the aim of restoring a diverse and functional gut microbiota. We propose here to refine the classification of canine CIEs by replacing the AREs category with a microbiota-related modulation-responsive enteropathies (MrMREs) category.

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Any Future for Faecal Microbiota Transplantation as a Novel Strategy for Gut Microbiota Modulation in Human and Veterinary Medicine?

Cited by 14 publications

References 216 publications

Fecal microbiota transplantation from Suncus murinus, an obesity-resistant animal, to C57BL/6NCrSIc mice, and the antibiotic effects in the approach

Fecal microbiota transplantation from Suncus murinus, an obesity-resistant animal, to C57BL/6NCrSIc mice, and the antibiotic effects in the approach

Personalized and Targeted Gut Microbiome Modulation in the Prevention and Treatment of Chronic Diseases

Updating the Classification of Chronic Inflammatory Enteropathies in Dogs

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