Aortic and Mitral Valve Calcification in Patients With End-Stage Renal Disease

Maher, E.R.; Young, Guy; Smyth-Walsh, Bernadette; Pugh, S.; Curtis, J. Randall

doi:10.1016/s0140-6736(87)91370-5

Cited by 234 publications

(132 citation statements)

References 21 publications

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“…There may be additional factors that lead to use of warfarin in patients with ESRD. Compared with the general population, these patients have an increased incidence and prevalence of aortic valve calcification and mitral annular calcification, which lead to aortic and mitral stenosis, respectively (15)(16)(17)(18). Patients who develop mitral stenosis are often put on long-term anticoagulation because they have increased rates of atrial fibrillation and are at risk for stroke (19).…”

Section: Discussionmentioning

confidence: 99%

Subdural Hematomas in Chronic Dialysis Patients

Sood¹,

Sinson²,

Cohen³

2007

Clinical Journal of the American Society of Nephrology

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Background and Objectives: Subdural hematoma is a known complication of long-term hemodialysis. Design, Setting, Participants, and Measurements: The US Renal Data System was used to determine the occurrence rate of nontraumatic subdural hematoma in long-term dialysis patients and to evaluate time trends.Results: The occurrence rate of subdural hematoma in long-term dialysis patients is 10 times higher than that of the general population. From 1991 to 2002, the occurrence rate of subdural hematoma in hemodialysis patients doubled, whereas it did not change in peritoneal dialysis patients.Conclusions: This high occurrence rate of subdural hematoma and its recent increase may be related to increased use of anticoagulants in long-term hemodialysis patients.Clin J Am Soc Nephrol 2: 956-959, 2007.

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Section: Discussionmentioning

confidence: 99%

Subdural Hematomas in Chronic Dialysis Patients

Sood¹,

Sinson²,

Cohen³

2007

Clinical Journal of the American Society of Nephrology

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“…[30][31][32] In light of these reports, derangements in calcium and/or phosphate metabolism may also lead to development of MAC without an underlying atherosclerotic disease. Nair, et al showed that the mean serum phosphorus and the product of serum calcium and phosphorus were higher in patients with MAC.…”

Section: Discussionmentioning

confidence: 99%

Is Carotid Atherosclerosis More Important in Patients With Mitral Annular Calcification Than in Those Without?

et al. 2004

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SUMMARYIt has been suggested that mitral annular calcification (MAC) may be a manifestation of generalized atherosclerosis. However, how the incidence and extent of coronary artery disease (CAD) are affected by the coexistence of carotid atherosclerosis (CAS) in patients with versus without MAC have not yet been studied.We studied 101 patients with echocardiographic MAC and 52 controls without MAC to investigate the clinical impact of CAS on the frequency and severity (defined as the number of obstructed vessels) of CAD in patients with MAC. Carotid Doppler ultrasonographic examination was performed on all patients before coronary angiography. In patients with both MAC and CAS, the incidences of CAD and multivessel disease (≥ 2 vessel or left main coronary artery disease) were significantly higher than in the control group with CAS alone (91% versus 68%, P = 0.008 and 76% versus 44%, P = 0.004, respectively). On the other hand, among study and control patients without CAS, although the frequencies of CAD and multivessel disease were higher in patients with MAC, interestingly, the differences were not statistically significant (37% versus 58% and 15% versus 26%, respectively, P > 0.05 for both). Stepwise multiple logistic regression analysis revealed that CAS (P < 0.001), MAC (P < 0.01) and, to a limited extent hypertension (P = 0.054), were independent predictors for the presence of CAD.In conclusion, the coexistence of CAS is more important in patients with MAC than in those without as it provides valuable information about the incidence and severity of underlying CAD. In cases with MAC but without CAS, MAC could be caused by factors other than atherosclerosis. (Jpn Heart J 2004; 45: 603-611)

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“…VC is potentially dangerous due to association with valve dysfunction, myocardial ischemia, conduction defects, infective endocarditic, and heart failure [9]. Previous studies based on imaging and echocardiography findings have revealed that the prevalence of calcification of the aortic and mitral valves in ESRD patients ranges from 30% to 50% [10,11]. The reported prevalence of aortic valve calcification (AVC) in HD patients is 28% to 55%, and it is 10% to 40% in mitral valve [9,12,13].…”

Section: Discussionmentioning

confidence: 99%

“…In the study of Sharma et al MVC predicted all-cause mortality, cardiovascular mortality and morbidity in ESRD patients [4]. MVC is common in the setting of ESRD [6,11,15,16] and in patients with chronic kidney disease before the onset of ESRD [17]. More recently, Fox et al have demonstrated that in the community, chronic kidney disease is associated with MVC before the onset of ESRD [17].…”

Section: Discussionmentioning

confidence: 99%

Cardiac valve calcifications and predictive parameters in hemodialysis patients

et al. 2007

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AbstractCardiac valvular calcification is frequent among hemodialysis (HD) patients. The presence of valvular calcification can help identify HD patients with a higher risk for cardiovascular diseases. Our aim was to determine the prevalence of valvular calcification (VC) in our maintenance hemodialysis (HD) population and to examine some possible etiologic factors for its occurrence. We studied forty-four patients on hemodialysis (23 women and 21 men; mean age 57 ± 18 year; mean HD duration 34 ± 28 months). Valvular calcification (VC) was observed in 21 patients (48%). Of these patients, 6 patients (13%) had mitral valvular calcification, 9 patients (20%) had aortic valvular calcification, and 6 patients (13%) had calcification of both valves. The patients with VC were older than patients without VC (66±14 vs. 50±18). The patients with aortic calcification had longer HD duration than others (48±29 vs. 27±24 months). Patients with VC had higher systolic and diastolic blood pressures than patients without VC. The patients with mitral calcification had higher C-reactive protein (CRP) levels (14 ± 13 vs. 7 ± 7). No significant differences were found with respect to calcium, phosphorus, parathyroid hormone, alkaline phosphatase and mean Ca × P product. Our study confirmed that there is an increased prevalence of VC in HD patients. Age is a risk factor for cardiac VC in HD patients. Longer HD duration was associated with aortic valve calcification. In addition, elevated level of CRP is associated with mitral valve calcification in HD patients.

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Aortic and Mitral Valve Calcification in Patients With End-Stage Renal Disease

Cited by 234 publications

References 21 publications

Subdural Hematomas in Chronic Dialysis Patients

Subdural Hematomas in Chronic Dialysis Patients

Is Carotid Atherosclerosis More Important in Patients With Mitral Annular Calcification Than in Those Without?

Cardiac valve calcifications and predictive parameters in hemodialysis patients

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