Aortic aneurysm as a complication of myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis

Satomura, Atsushi; Fujita, Takayuki; Maruyama, Takashi; Hamada, Hatsuyuki; Nozawa, Yoshinori; Takayama, Etsuyo; Nakayama, T

doi:10.1515/med-2017-0065

Cited by 2 publications

(2 citation statements)

References 18 publications

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“… 12 13 Although large vessel vasculitis is likely to be a consequence of BD involvement, AAV can also provoke large vessel vasculitis: so far, several case series have reported that large vessel vasculitis might be associated with AAV and have indicated that large vessel vasculitis can occur in a spectrum of various clinical features. 14 15 16 Thus, vascular manifestations that characterize large vessel vasculitis in ANCA-positive BD patients are likely to contributable to both BD and AAV. In our study, we did not notice any ANCA-positive BD patients who exhibited vena cava thrombosis or aorta involvement.…”

Section: Discussionmentioning

confidence: 99%

Antineutrophil Cytoplasmic Antibody Positivity Is Associated with Vascular Involvement in Behçet's Disease

et al. 2021

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Purpose We investigated whether antineutrophil cytoplasmic antibody (ANCA) positivity is associated with vascular manifestations at diagnosis of Behçet's disease (BD) and poor outcomes during follow-up. Materials and Methods We retrospectively reviewed the medical records of 1060 patients with BD. Among them, 808 patients could be diagnosed with BD based on the revised version of the International Criteria for Behçet's Disease (ICBD) in 2014 (2014 ICBD criteria) and 588 patients could be diagnosed with BD based on the International Study Group (ISG) criteria proposed in 1990 (1990 ISG criteria). We examined the sites and patterns of vascular involvement in the BD patients at diagnosis and evaluated adverse outcomes during follow up, such as all-cause mortality, acute coronary syndrome, and deep vein thrombosis. Results Among the 808 patients with BD based on the 2014 ICBD criteria, the rate of ANCA positivity at diagnosis was 2.2%. ANCA-positive BD patients exhibited a higher frequency of overall vascular manifestations (22.2% vs. 6.1%) and higher frequencies of vascular involvement in the upper extremities and visceral arteries than ANCA-negative BD patients (5.6% vs. 0.1% and 5.6% vs. 0.1%). Among the 588 BD patients based on the 1990 ISG criteria, similarly, ANCA-positive BD patients exhibited a higher frequency of vascular manifestations than ANCA-negative BD patients. ANCA positivity, however, did not seem to be associated with poor outcomes in BD patients during follow up. Conclusion ANCA positivity in BD patients was found to be associated with cross-sectional vascular involvement in the upper extremities and visceral arteries at diagnosis but was not predictive of poor outcomes during follow-up.

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Section: Discussionmentioning

confidence: 99%

Antineutrophil Cytoplasmic Antibody Positivity Is Associated with Vascular Involvement in Behçet's Disease

et al. 2021

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“…Through a search of AAV-related aortic aneurysm cases in the Pubmed database, together with the case of MPO-AAV combined with AAA that we reported, we found a total of 11 articles reporting 14 cases of AAV combined with aortic aneurysm(Table 1). [3][4][5][6][7][8][9][10][11][12][13] This included seven patients diagnosed with GPA-AAVand two patients with MPA, while the remaining five patients had no pathological results. Among these 14 cases, nine were abdominal aortic aneurysms and five were thoracic aortic aneurysms.…”

Section: Discussionmentioning

confidence: 99%

ANCA-associated vasculitis with abdominal aortic aneurysm : Case report and literature review

Wang

2022

Vascular

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Introduction ANCA-associated vasculitis is an autoimmune disease that usually involves the small vessel walls. It is difficult to find the presence of ANCA-associated vasculitis in the great arteries, especially the thoracic and abdominal aorta. Methods This is an 86-year-old Chinese man with ANCA-associated vasculitis and abdominal aortic aneurysm who presented with epigastric pain. Considering his age and physical condition, the patient was treated with methylprednisolone and mycophenolate mofetil instead of surgery. Results The patient’s epigastric pain symptoms were relieved after 2 months of conservative treatment. Imaging at follow-up 2 years later showed signs of aneurysm enlargement because of irregular medication. Conclusions Patients with ANCA-associated vasculitis combined with aortic aneurysm often require surgical management. But for patients with stable disease and poor physical conditions, conservative treatment is also an effective treatment method, which can bring benefits to the patient’s survival.

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Aortic aneurysm as a complication of myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis

Cited by 2 publications

References 18 publications

Antineutrophil Cytoplasmic Antibody Positivity Is Associated with Vascular Involvement in Behçet's Disease

Antineutrophil Cytoplasmic Antibody Positivity Is Associated with Vascular Involvement in Behçet's Disease

ANCA-associated vasculitis with abdominal aortic aneurysm : Case report and literature review

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