Aortic arch calcification is strongly associated with coronary artery calcification

Adar, Adem; Erkan, Hakan; Gökdeniz, Tayyar; Karadeniz, Ayşegül; Çavuşoğlu, İsmail Gökhan; Özer, Orhan

doi:10.1024/0301-1526/a000415

Cited by 19 publications

(16 citation statements)

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“…In our study, we found a significant association between AAC and severe coronary calcification as defined by the SS algorithm. Several previous studies strongly and consistently support a significant, positive association between AAC on chest X-rays and CAC that is detected by computed tomography (CT) [7, 8]. Bannas et al evaluated the association between AAC on chest X-rays and CAC scores that were determined by CT, where the AAC extent was divided into the same four grades (0-3) as the present study.…”

Section: Discussionsupporting

confidence: 67%

“…Moreover, AAC can be detected readily and reproducibly using chest X-ray, which is a simple, inexpensive tool that is widely available for assessing hospitalized patients with chest pain. Several studies have reported that the presence of AAC could serve as an independent predictor of coronary artery calcium (CAC) presence, while the AAC extent was correlated with CAC scores [7, 8]. Furthermore, CAC has been demonstrated to provide incremental and independent power in predicting CAD severity [9, 10], suggesting that AAC might be a good predictor for CAD severity.…”

Section: Introductionmentioning

confidence: 99%

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Aortic Arch Calcification Is a Strong Predictor of the Severity of Coronary Artery Disease in Patients with Acute Coronary Syndrome

Hou

Tian

et al. 2019

BioMed Research International

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Background. The purpose of this study was to investigate the correlation of the extent of aortic arch calcification (AAC) detectable on chest X-rays with the severity of coronary artery disease (CAD) as evaluated by the SYNTAX score (SS) in patients with acute coronary syndrome (ACS). Methods. A total of 1,418 patients (344 women; 59 ± 10 years) who underwent coronary angiography for ACS and were treated with coronary revascularization were included in the present study; chest X-rays were performed on admission. The AAC extent was divided into four grades (0–3). SS was calculated based on each patient’s coronary angiographic findings. The relationship between the AAC extent and SS was assessed. Results. The AAC extent was positively correlated with SS (ρ = 0.639, P < 0.001). In the multivariate analysis, compared with grade 0, odds ratios (ORs) of AAC grades 1, 2, and 3 in predicting SS >22 were 12.95 (95% CI, 7.85–21.36), 191.76 (95% CI, 103.17–356.43), and 527.81 (95% CI, 198.24–1405.28), respectively. Receiver operating characteristic curve analysis yielded a strong predictive ability of the AAC extent for SS >22 (area under curve = 0.840, P < 0.001). Absence of AAC had a sensitivity, specificity, positive prognostic value, negative prognostic value, and accuracy of 46.7%, 95.9%, 94.1%, 56.4%, and 67.3%, respectively, for SS ≤22. AAC grades ≥2 had a sensitivity of 66.3%, specificity of 89.2%, positive prognostic value of 81.5%, negative prognostic value of 78.6%, and accuracy of 79.6% for the correct identification of SS >22. Conclusions. The extent of AAC detectable on chest X-rays might provide valuable information in predicting CAD severity in ACS patients.

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Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Aortic Arch Calcification Is a Strong Predictor of the Severity of Coronary Artery Disease in Patients with Acute Coronary Syndrome

Hou

Tian

et al. 2019

BioMed Research International

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“…In another study, a strong and independent correlation was found between coronary artery calcification and AAC [22]. In addition, a strong correlation was reported between AAC and renal artery calcification, which is an important indicator of renal artery disease [23].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Aortic Arch Calcification, Detected by Chest X-Ray, and Renal Resistive Index in Patients with Hypertension

et al. 2018

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Objective: Aortic arch calcification (AAC) is a surrogate marker for arterial stiffness and hypertension-related vascular damage. Renal resistive index (RRI), a renal Doppler ultrasonography parameter, is used to assess renal hemodynamics. In this study, we aimed to evaluate the relationship between RRI and AAC in patients with hypertension. Methods: Patients with hypertension underwent a chest X-ray and re nal Doppler ultrasonography. They were divided into two groups according to RRI (group 1: RRI ≥0.70; group 2: RRI < 0.70). Two examiners, blinded to the findings of RRI, reviewed the AAC in these patients. The kappa value was detected to be 0.781 and a p value < 0.001 was considered significant. Results: The study included 289 hypertensive patients (mean age 63.87 ± 11.38 years). In 53.6% (n = 155) of the study subjects, RRI was observed to be ≥0.70. Patients with RRI ≥70 were older and had more prevalent AAC as well as left ventricular hypertrophy. A multiple linear regression analysis was carried out to test whether presence of AAC significantly predicted RRI. The results of the regression analysis indicated that presence of AAC significantly predicted RRI (β = 0.053; p < 0.001). Conclusions: A strong and independent relationship was found between AAC on chest X-ray and RRI in patients with hypertension.

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“…Conventional radiography is a convenient and inexpensive tool for identifying calcium ions in blood vessels [21-23]. In the general population, aortic arch calcification (AAC) found in chest radiotherapy has been shown to be associated with cardiovascular mortality during long-term follow-up [24]. Recent studies have shown that high-grade calcification was associated with cardiovascular and all-cause mortality in patients with HD using plain chest radiography [25].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Solute Clearance, Hospitalization Rate, and Aortic Arch Calcification between Online Hemodiafiltration and High-Flux Hemodialysis: A 6-Year Observational Study

Hao

Yang

et al. 2019

Kidney Blood Press Res

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Background/Aims: Studies on the long-term clinical benefits of hemodiafiltration (HDF) and high-flux hemodialysis (HFHD) are very limited. This study aimed to investigate the hospitalization rate and aortic arch calcification (AAC) of these two dialysis modalities over 6 years. Methods: Participants who received regular HDF and HFHD in one hospital-facilitated hemodialysis center were prospectively enrolled after matching for age, sex, and diabetes between January 2009 and December 2014. Medical records were reviewed retrospectively on demographics, laboratory variables, calcified scores in aortic arch measured by chest radiography, and rates of hospital admission. Cox proportional hazard regression and linear regression were used to obtain the outcome results. Results: The HDF and HFHD groups consisted of 108 and 102 participants, respectively. Levels of laboratory variables including small soluble solutes and Kt/V were not statistically different over the 6-year period between the HDF and HFHD groups. Calcified scores of the aortic arch increased over 6 years in both groups. The changes in the mean calcified scores were significant when compared between the two groups (0.44–1.82 in HFHD, 0.79–1.8 in HDF, respectively, p = 0.008). Hospitalization rates were 735 per 1,000 patients in the HDF group and 852 per 1,000 patients in the HFHD group, respectively. No significant difference was observed in frequency and days of hospitalization between HDF and HFHD. Conclusion: Hospitalization rates and AAC were observed to be equal for HDF and HFHD.

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Aortic arch calcification is strongly associated with coronary artery calcification

Abstract: AAC is a strong and independent predictor of CAC. The discriminative performance of AAC is high in detecting patients with low- and high-risk CAC scores.

Cited by 19 publications

References 0 publications

Aortic Arch Calcification Is a Strong Predictor of the Severity of Coronary Artery Disease in Patients with Acute Coronary Syndrome

Aortic Arch Calcification Is a Strong Predictor of the Severity of Coronary Artery Disease in Patients with Acute Coronary Syndrome

Relationship between Aortic Arch Calcification, Detected by Chest X-Ray, and Renal Resistive Index in Patients with Hypertension

Comparison of Solute Clearance, Hospitalization Rate, and Aortic Arch Calcification between Online Hemodiafiltration and High-Flux Hemodialysis: A 6-Year Observational Study

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