Aortic atherosclerosis in hoofed mammals

Stout, Clarke; Bohorquez, F.

doi:10.1016/s0368-1319(69)80068-2

Cited by 12 publications

(4 citation statements)

References 7 publications

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“…Spontaneous atherosclerosis can occur in swine and ruminant species [197][198][199][200] . Experimental induction of this disease has been performed in calves and goats, with reported characteristics similar to human atherosclerosis 168,201,202 .…”

Section: Atherosclerosismentioning

confidence: 99%

Large animal models of cardiovascular disease

Tsang

Rashdan

Whitelaw

et al. 2016

Cell Biochemistry & Function

117

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The human cardiovascular system is a complex arrangement of specialized structures with distinct functions. The molecular landscape, including the genome, transcriptome and proteome, is pivotal to the biological complexity of both normal and abnormal mammalian processes. Despite our advancing knowledge and understanding of cardiovascular disease (CVD) through the principal use of rodent models, this continues to be an increasing issue in today's world. For instance, as the ageing population increases, so does the incidence of heart valve dysfunction. This may be because of changes in molecular composition and structure of the extracellular matrix, or from the pathological process of vascular calcification in which bone‐formation related factors cause ectopic mineralization. However, significant differences between mice and men exist in terms of cardiovascular anatomy, physiology and pathology. In contrast, large animal models can show considerably greater similarity to humans. Furthermore, precise and efficient genome editing techniques enable the generation of tailored models for translational research. These novel systems provide a huge potential for large animal models to investigate the regulatory factors and molecular pathways that contribute to CVD in vivo. In turn, this will help bridge the gap between basic science and clinical applications by facilitating the refinement of therapies for cardiovascular disease. 2016 The Authors. Published by John Wiley & Sons Ltd.

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Section: Atherosclerosismentioning

confidence: 99%

Large animal models of cardiovascular disease

Tsang

Rashdan

Whitelaw

et al. 2016

Cell Biochemistry & Function

117

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“…Several reports on spontaneous degenerative lesions in the aortas and coronary arteries of cattle and buffaloes have appeared recently (KNIERIEM et al, 1968;MCKINNEY, 1968;STOUT and BOHORQUEZ, 1969;LIKAR et al, 1969;WIGGERS et al, 1971;SINGH, 1973;DIXIT et al, 1973;BASAK et al, 1974;BHALLA, 1977a, 1977b;GUDTA et al, 1978). Some of these lesions are comparable to those described in man and in other domestic animals.…”

mentioning

confidence: 99%

Spontaneous Lesions in Cerebral Arteries of Cattle and Buffalo

Bhalla¹,

Prasad²

2010

Zentralblatt Für Veterinärmedizin Reihe A

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Summary The basilar artery, along with the Circle of Willis, were collected from 83 bovine brains (cattle 47, buffalo 36). The animals were mainly of nondescript breed and ranged in age from one week to 15 years and were of either sex. No gross lesions were observed but various microscopic lesions (intimal thickening, fibrous plaque and medial vacuolation) were seen in both species (31 cattle, 27 buffalo). The frequency, distribution and morphology of the lesions are described. Zusammenfassung Spontane Läsionen in den Gehirnarterien bei Rindern und Büffeln Von 83 Gehirnen (47 Rinder, 36 Büffel) wurden die Arteria basilaris und der Circulus arteriosus cerebri (Circle of Willis) entnommen. Das Alter der Tiere, deren Rasse meistens nicht näher bekannt war, schwankte zwischen einer Woche und 15 Jahren. Das Untersuchungsmaterial stammte teils von männlichen, teils von weiblichen Tieren. Makroskopisch konnten keine Veränderungen festgestellt werden, hingegen wurden bei 31 Rindern und 27 Büffeln verschiedene mikroskopische Läsionen (Intimaverdickungen, fibröse Plaques, Vakuolisierungen in den glatten Muskelzellen der Media) gefunden. Häufigkeit, Verteilung und Morphologie der verschiedenen Läsionen werden beschrieben. Résumé Lésions spontanées dans les artères cérébrales chez des bovins et des buffles Arteria basilaris et Circulus arteriosus cerebri (cercle de Willis) ont été prélevés sur 83 cerveaux (47 bovins, 36 buffles). L'âge des animaux dont les races n'ont pu être précisées, variait entre 1 semaine et 15 ans. Le matériel provenait en partie d'animaux mâles et femelles. On n'a pas trouvé de lésions macroscopiques; par contre, des lésions microscopiques ont été mises en évidence chez 31 bovins et 27 buffles (épaississement de l'Intima, plaques fibreuses, vacuolisation dans les cellules de la musculature lisse de la Media). La fréquence, la répartition et la morphologie des différentes lésions sont décrites. Resumen Lesiones espontáneas en las arterias cerebrales de vacunos y büfalos De 83 cerebros (47 vacunos, 36 búfalos) se recogieron la arteria basilar junta con el círculo arterioso cerebral (círculo de Willis). La edad de los animales, cuyas razas en su mayoría eran inclasificables, oscilaba entre 1 semana y 15 años. El material de análisis procedía en parte de animales machos, en parte de hembras. No se pudieron comprobar modificaciones macroscópicas, mientras que en 31 vacunos y 27 búfalos se hallaron diferentes lesiones microscópicas (espesamientos de la túnica interna, placas fibrosas, vacuolizaciones en las células musculares lisas de la media). Se describen la frecuencia, distribución y morfología de las distintas lesiones.

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“…Jennings, Jennings and Burton (1969) found cardiovascular lesions in all of 19 male Red deer taken from an island near Scotland. Stout and Bohorquez (1969) reported atherosclerosis in Cervidae kept in zoos.…”

Section: Body Cholesterolmentioning

confidence: 99%

Atherosclerosis in ruminants

Wiggers

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Aortic atherosclerosis in hoofed mammals

Cited by 12 publications

References 7 publications

Large animal models of cardiovascular disease

Large animal models of cardiovascular disease

Spontaneous Lesions in Cerebral Arteries of Cattle and Buffalo

Atherosclerosis in ruminants

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