Aortic collagen synthesis in rabbits following removal of atherogenic diet

Langner, Ronald O.; Modrak, John B.

doi:10.1016/0014-4800(77)90058-2

Cited by 9 publications

(5 citation statements)

References 12 publications

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“…45 It is of interest that previous studies indicated that prolyl hydroxylase activity was not elevated in 60 days after feeding a 2% cholesterol diet, but does become elevated in the aorta of rabbits fed this diet for 60 days followed by 20 or 30 days of feeding a cholesterol-free, regression diet. 21 In our present study, the activity of this intracellular enzyme of collagen biosynthesis was significantly elevated in diseased aortic tissue of animals fed the more fibrogenic peanut oil-cholesterol diet for 60 days without subsequent introduction of a regression diet. This variation may reflect the generally stimulatory, more fibrogenic influence of the peanut oil component of the diet, and may be indirectly attributable to specific components of the peanut oil diet previously suggested to be the bases for its fibrogenic affect.…”

supporting

confidence: 47%

“…The increase in connective tissue protein synthesis previously shown to occur in this and similar animal models of atherosclerosis 319 " 21 probably reflects the increased proliferation and biosynthetic capacity of fibrogenic cells involved in atherosclerotic lesions. Our present studies show that this response included a marked increase in the activity of lysyl oxidase, an essential enzymatic component of fibrogenesis, since this enzyme initiates crosslinkage formation in elastin and collagen.…”

mentioning

confidence: 60%

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Changes in aortic lysyl oxidase activity in diet-induced atherosclerosis in the rabbit.

Kagan¹,

Raghavan²,

Hollander³

1981

Arteriosclerosis

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This study assessed the response of lysyl oxidase, the enzyme that initiates covalent crosslinking in elastin and collagen, by studying the aortic tissue of rabbits after arteriosclerosis had been induced by diet. Rabbits in the experimental group were fed an atherogenic diet of rabbit chow supplemented with 8% peanut oil and 2% cholesterol for varying periods of time, while the control group was fed only rabbit chow. Lysyl oxidase activity was found to be distributed throughout the length of the thoracic and abdominal aortas of the normal rabbits. However, rabbits fed the atherogenic diet showed marked increases in enzyme activity in the aortic arch, a change that was initially evident after 30 days and became greatest (2.5 times that of the controls) after 90 days. Enzyme activity in the study rabbits increased only minimally in the abdominal aortic wall. Aortic prolyl hydroxylase activity measured after 60 days of feeding changed in degree and manner similar to lysyl oxidase activity. These region-specific changes in enzyme activities correlated with the distribution and severity of aortic lesions in this model of the disease. Lysyl oxidase activity increased dramatically in this model of atherosclerosis, suggesting that this extracellular enzyme activity may prove to be a vulnerable and accessible point of control of the fibrotic response in atherosclerosis. (Arteriosclerosis 1981; 1:287-291)

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supporting

confidence: 47%

mentioning

confidence: 60%

Changes in aortic lysyl oxidase activity in diet-induced atherosclerosis in the rabbit.

Kagan¹,

Raghavan²,

Hollander³

1981

Arteriosclerosis

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“…In previous studies we demonstrated that when cholesterol was removed from the diet, serum cholesterol values fell rapidly but were still significantly elevated after 30 days. 11 In this study, plasma cholesterol values in the regression group were at control levels by the time the animals were killed.…”

Section: Resultsmentioning

confidence: 87%

Lesion regression and protein synthesis in rabbits after removal of dietary cholesterol.

Langner¹,

Bement²

1985

Arteriosclerosis

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This study was conducted to determine whether atherosclerotic lesions regressed in rabbits that were placed on a normal, low cholesterol diet. Rabbits (n = 16) were fed a 2% cholesterol diet for 90 days; nine rabbits were killed, and the remaining seven rabbits were fed a low cholesterol diet for 7 months. Appropriate noncholesterol-fed controls were used with each group. After 90 days of cholesterol feeding, the rabbits' thoracic aortas showed severe lesions, accompanied by significantly elevated rates of collagen and noncoilagen protein synthesis and significantly increased amounts of cholesterol and soluble collagen. Cholesterol-fed rabbits that were fed a normal diet for 7 months had normal serum cholesterol levels, but exhibited extensive aortic lesions with elevated cholesterol content. Biochemically, the rate of aortic collagen synthesis remained significantly elevated above control values; however, the collagen content was not different from controls. This lack of collagen accumulation in the presence of a prolonged increase in synthetic rate was surprising. One possible explanation is that in the diseased aorta there is a rapid turnover of collagen, resulting in a redistribution or remodeling of the connective tissue, rather than an increased accumulation. (Arteriosclerosis 5:74-79, January/February 1985)

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“…Other histological studies (Langner & Modrak, 1977;Wissler & Vesselinovich 1968) have also shown that the continuous feeding of cholesterol to rabbits produces similarly a fatty 'foam-cell' type of aortic intimal lesion. However, this experimental model has been criticised because the foam-cell lesion lacks the fibrous cap which is characteristic of the advanced lesion in man (NHLI, 1972).…”

Section: Discussionmentioning

confidence: 88%

“…Langner & Modrak (1976a), however, demonstrated that continuous cholesterol feeding will by itself stimulate tissue collagen formation, but in a further study (Langner & Modrak, 1977) suggested that alternating feeding periods of diets containing high and normal cholesterol levels would be a greater stimulus to aortic collagen formation.…”

mentioning

confidence: 98%

Experimental study of the effects on rabbits of the injectable contraceptive medroxyprogesterone acetate, cholesterol feeding and drug-atherogenic diet combination

1982

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Medroxyprogesterone acetate was given alone or in combination with a cholesterol-rich diet. Total serum cholesterol levels in treated rabbits was significantly different from those of the control on most occasions during the experiment, and in the controls it remained essentially the same throughout the experimental period. There was a relationship between lesions induced and the raised serum cholesterol, but there was no regression of the appearance of fibrous plaques after discontinuation of the cholesterol supplement.

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Aortic collagen synthesis in rabbits following removal of atherogenic diet

Cited by 9 publications

References 12 publications

Changes in aortic lysyl oxidase activity in diet-induced atherosclerosis in the rabbit.

Changes in aortic lysyl oxidase activity in diet-induced atherosclerosis in the rabbit.

Lesion regression and protein synthesis in rabbits after removal of dietary cholesterol.

Experimental study of the effects on rabbits of the injectable contraceptive medroxyprogesterone acetate, cholesterol feeding and drug-atherogenic diet combination

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