Aortic compliance measurements using doppler ultrasound: In vivo biochemical correlates

Lehmann, Eldon D.; Hopkins, KD; Gosling, R. G.

doi:10.1016/0301-5629(93)90087-5

Cited by 102 publications

(76 citation statements)

References 81 publications

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“…6,7 PWV was recorded transcutaneously by two piezoelectrical pressure transducers. 20 One transducer was positioned over the left common carotid artery and another over the left femoral artery.…”

Section: Measurementsmentioning

confidence: 99%

“…4,5 A high SBP is closely related to a stiffer aorta. 6,7 Aortic stiffness can be evaluated noninvasively by measuring pulse wave velocity (PWV) along the descending aorta by ultrasound Doppler techniques. 7 A faster PWV indicates a stiffer aorta.…”

Section: Introductionmentioning

confidence: 99%

“…6,7 Aortic stiffness can be evaluated noninvasively by measuring pulse wave velocity (PWV) along the descending aorta by ultrasound Doppler techniques. 7 A faster PWV indicates a stiffer aorta. 7 Recently, several studies have been published, which indicate that PWV may be a stronger risk factor for CVD than SBP, [8][9][10][11] and it has been suggested that PWV may represent a useful integrated index of vascular status and hence CVD risk.…”

Section: Introductionmentioning

confidence: 99%

“…7 A faster PWV indicates a stiffer aorta. 7 Recently, several studies have been published, which indicate that PWV may be a stronger risk factor for CVD than SBP, [8][9][10][11] and it has been suggested that PWV may represent a useful integrated index of vascular status and hence CVD risk. 11 High insulin level is believed to play an important role in the development and clinical course of high BP and CVD.…”

Section: Introductionmentioning

confidence: 99%

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Relation between insulin and aortic stiffness: a population-based study

et al. 2003

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Recent studies have suggested that a high pulse wave velocity (PWV), a measure of aortic stiffness, may be a stronger risk factor for cardiovascular disease (CVD) than a high blood pressure (BP). The relation between insulin, believed to play an important role in the development and clinical course of high BP, and PWV is not yet clear. Therefore, we decided to examine the relationship between insulin and PWV in a large population-based study. The study population consisted of a random sample of 1213 women and 1207 men (age range, 41-72 years) without a history of myocardial infarction or stroke. Fasting insulin was determined together with conventional risk factors for CVD. PWV was recorded transcutaneously by a mechanical electrical principle with one transducer positioned over the left common carotid artery, and another over the left femoral artery. In univariate analysis, insulin was highly significantly related to PWV (standardized regression coefficient: 0.0669 7 0.0051; Po0.001). In multivariate analysis, controlling for all well-established predictors of PWV, such as age, systolic BP or mean BP and pulse pressure, sex, and heart rate, as well as controlling for conventional risk factors for CVD and use of BP-lowering drugs, the level of insulin remained a significant predictor of PWV (standardized regression coefficient: 0.0122 7 0.0048; P ¼ 0.012). In conclusion, the present study found that a higher insulin level was related to a higher PWV. This indicates that hyperinsulinaemia may affect BP and risk of CVD by increasing aortic stiffness.

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Section: Measurementsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relation between insulin and aortic stiffness: a population-based study

et al. 2003

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“…Atherosclerosis also has been implicated in the alteration of the pulsatile characteristics of blood vessels. 39,40 However, the relation between altered mechanical properties of blood vessels and atherosclerosis is complex and probably involves both structural and functional influences that have led to conflicting reports in the literature. 41 An attractive hypothesis consistent with the data are that altered endothelial function is at the root of the large and small artery compliance reduction with aging.…”

Section: Figurementioning

confidence: 99%

Age-Related Abnormalities in Arterial Compliance Identified by Pressure Pulse Contour Analysis

et al. 1999

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Abstract-The objective of this study was to evaluate age-related changes in pulsatile arterial function. Aging alters arterial pulsatile function and produces consistent changes in the pressure pulse contour. A reduced systemic arterial compliance that can be derived from analysis of the pulse contour is regarded as the best clinical index of impaired pulsatile arterial function and may mark the presence of early vascular damage. We analyzed intra-arterial brachial artery waveforms in 115 healthy normotensive volunteers (83 men, 32 women) and radial artery waveforms obtained with the use of a calibrated tonometer device in 212 healthy volunteers (147 women, 65 men). A computer-based assessment of the diastolic pressure decay and a modified Windkessel model of the circulation were used to quantify changes in arterial waveform morphology in terms of large artery or capacitive compliance, oscillatory or reflective compliance in the small arteries, inertance, and systemic vascular resistance. Large artery compliance and oscillatory compliance correlated negatively with age for both invasive and noninvasive groups (rϭϪ0. 50 and rϭϪ0.55; rϭϪ0.37 and rϭϪ0.66; PϽ0.001 for all). The slopes of the regression lines for the decline in oscillatory compliance with age were significantly steeper than those recorded for large artery compliance estimates. The change in blood pressure with age independently contributed to the decrease in large artery compliance but not oscillatory compliance in both groups. Consistent age-related changes were found in the pressure pulse contour by analysis of waveforms obtained invasively or noninvasively from the upper limb. The change in the oscillatory or reflective compliance estimate was independent of blood pressure change and may represent a better marker than large artery or capacitive compliance of the degenerative aging process in altering pulsatile arterial function. (Hypertension. 1999;33:1392-1398.)Key Words: age Ⅲ compliance Ⅲ resistance Ⅲ impedance A daptations in the arterial vasculature play a critical role in influencing cardiovascular hemodynamics with advancing age. 1 The generalized structural and functional changes in the arterial circulation contribute to alterations in regional blood flow, progression of atherogenesis, and the microvascular abnormalities that occur during senescence. 2 In large arteries, aging results in progressive deposition of calcium salts, fraying and fragmentation of elastin, and an increase in the number and cross-linking of collagen fibers that alter the compliance characteristics of the vessel wall. 3 A rigid aorta is less able to buffer the pulsatile output from the heart; it contributes to an increase in systolic blood pressure and left ventricular afterload and a decrease in diastolic blood pressure and impaired coronary perfusion. Recent evidence suggests that an increase in pulse pressure is accompanied by progressive vessel wall damage and atherogenesis and is associated with an increase in cardiac morbidity and mortality rates. 4,5 In addi...

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Increase in aortic pulse wave velocity is associated with abnormal postprandial triglyceride response

et al. 2005

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SummaryBackground: Aortic pulse wave velocity (aPWV), an index of aortic distensibility, and postprandial hypertriglyceridemia are recognized as independent cardiovascular risk factors.Hypothesis: The aim of this study was to evaluate the relationship between postprandial hypertriglyceridemia and changes in aPWV.Methods: We prospectively studied 45 patients (mean age 48 [14] years, 28.9% men), who were submitted to a standardized fat meal (FM) test. According to their triglyceride (TG) levels 2, 4, 6, and 8 h after the FM, the patients were divided into two groups: Group 1 (31 patients) with postprandial TG levels ≤ 219 mg/dl, and Group 2 (14 patients) with TG levels > 219 mg/dl at one of the aforementioned time intervals. Before and 6 h after the FM, aPWV was measured noninvasively.Results: Baseline characteristics in the two groups were similar, except for higher TG, pulse pressure, waist-to-hip ratio, percentage of patients who smoked or had arterial hypertension, and lower high-density lipoprotein cholesterol levels in Group 2. Postprandially, aPWV was higher in Group 2 [11.2(2.7) vs. 9.1(2.1) m/s, p = 0.004]. Changes in aPWV correlated with TG changes from baseline to 6 h after FM (r = 0.539, p < 0.001) and with the areas under the TG curve (r = 0.617, p < 0.001). A postprandial TG increase of 100 mg/dl resulted in a 0.88 m/s rise of aPWV.

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Aortic compliance measurements using doppler ultrasound: In vivo biochemical correlates

Cited by 102 publications

References 81 publications

Relation between insulin and aortic stiffness: a population-based study

Relation between insulin and aortic stiffness: a population-based study

Age-Related Abnormalities in Arterial Compliance Identified by Pressure Pulse Contour Analysis

Increase in aortic pulse wave velocity is associated with abnormal postprandial triglyceride response

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