Aortic excess pressure and arterial stiffness in subjects with subclinical white matter lesions

Katulska, Katarzyna; Wykrętowicz, M.; Mińczykowski, Andrzej; Krauze, Tomasz; Milewska, Agata; Piskorski, Jarosław; Marciniak, Ryszard; Stajgis, Marek; Wysocki, Henryk; Guzik, Przemysław; Wykretowicz, Andrzej

doi:10.1016/j.ijcard.2013.12.247

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…For example, increases in physical activity are associated with reduced carotid artery stiffness and improved brain perfusion and executive performance [38]. In addition, age-related elevation in central artery stiffness and pulse pressure has been shown to be associated positively with cerebral blood flow pulsatility and WM lesion volume which may be reversed with aerobic exercise training [39–42]. Further, Tarumi et al have demonstrated that the decreases in FA and elevations in RD are associated with central arterial stiffening and reduced baroreflex sensitivity in many brain regions, suggesting a link between cardiovascular and brain health [43].…”

Section: Discussionmentioning

confidence: 99%

Cardiorespiratory Fitness and White Matter Neuronal Fiber Integrity in Mild Cognitive Impairment

Ding

Tarumi

Zhu

et al. 2017

JAD

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Section: Discussionmentioning

confidence: 99%

Cardiorespiratory Fitness and White Matter Neuronal Fiber Integrity in Mild Cognitive Impairment

Ding

Tarumi

Zhu

et al. 2017

JAD

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“…Cerebral circulation has a high flow, low vascular resistance and impedance which may facilitate the transmission of hemodynamic pulsatility (O’Rourke and Safar, 2005). Age-related elevations in central artery stiffness and pulse pressure are independently associated with the higher levels of cerebral blood flow pulsatility and WM lesion volume (Aribisala et al, 2014; Katulska et al, 2014; Mitchell et al, 2011; Tarumi et al, 2014). Mechanistically, excessive pulsatile shear stress on cerebral microcirculations may damage vascular endothelium and blood-brain barrier whose integrity has been shown as a neuropathological correlate of WM lesions (Young et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Central artery stiffness, baroreflex sensitivity, and brain white matter neuronal fiber integrity in older adults

et al. 2015

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Cerebral hypoperfusion elevates the risk of brain white matter (WM) lesions and cognitive impairment. Central artery stiffness impairs baroreflex, which controls systemic arterial perfusion, and may deteriorate neuronal fiber integrity of brain WM. The purpose of this study was to examine the associations among brain WM neuronal fiber integrity, baroreflex sensitivity (BRS), and central artery stiffness in older adults. Fifty-four adults (65±6 years) with normal cognitive function or mild cognitive impairment (MCI) were tested. The neuronal fiber integrity of brain WM was assessed from diffusion metrics acquired by diffusion tensor imaging. BRS was measured in response to acute changes in blood pressure induced by bolus injections of vasoactive drugs. Central artery stiffness was measured by carotid-femoral pulse wave velocity (cfPWV). The WM diffusion metrics including fractional anisotropy (FA) and radial (RD) and axial (AD) diffusivities, BRS, and cfPWV were not different between the control and MCI groups. Thus, the data from both groups were combined for subsequent analyses. Across WM, fiber tracts with decreased FA and increased RD were associated with lower BRS and higher cfPWV, with many of the areas presenting spatial overlap. In particular, the BRS assessed during hypotension was strongly correlated with FA and RD when compared with hypertension. Executive function performance was associated with FA and RD in the areas that correlated with cfPWV and BRS. These findings suggest that baroreflex-mediated control of systemic arterial perfusion, especially during hypotension, may play a crucial role in maintaining neuronal fiber integrity of brain WM in older adults.

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Correlation of Cerebral White Matter Lesions with Carotid Intraplaque Neovascularization assessed by Contrast-enhanced Ultrasound

Wang

Jiang

Huang

et al. 2020

Journal of Stroke and Cerebrovascular Diseases

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Aortic excess pressure and arterial stiffness in subjects with subclinical white matter lesions

Cited by 7 publications

References 9 publications

Cardiorespiratory Fitness and White Matter Neuronal Fiber Integrity in Mild Cognitive Impairment

Cardiorespiratory Fitness and White Matter Neuronal Fiber Integrity in Mild Cognitive Impairment

Central artery stiffness, baroreflex sensitivity, and brain white matter neuronal fiber integrity in older adults

Correlation of Cerebral White Matter Lesions with Carotid Intraplaque Neovascularization assessed by Contrast-enhanced Ultrasound

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