Aortic pulse wave velocity and HeartSCORE: Improving cardiovascular risk stratification. A sub-analysis of the EDIVA (Estudo de DIstensibilidade VAscular) project

Pereira, Telmo; Maldonado, João; Polónia, Jorge; Silva, J. A.; Rodrigues, Ticiana da Costa; Marques, Mário C.

doi:10.3109/08037051.2013.823760

Cited by 17 publications

(14 citation statements)

References 27 publications

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“…Physiological measurements of vascular stiffness and vessel wall thickness serve as surrogate risk markers of future cardiovascular risk [10,11]. Well-established and widely used vascular measures are carotid intima-media thickness (cIMT), pulse wave velocity (PWV) and augmentation index (AIX) [12][13][14]. They measure different vascular properties in distinct parts of the arterial tree, but are not entirely independent of each other, and covary to some extent [15].…”

Section: Introductionmentioning

confidence: 99%

Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study

Pettersson-Pablo

Cao

Bäckström

et al. 2020

BMC Cardiovasc Disord

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Background: Identification of early signs of atherosclerosis in young adults have the potential to guide early interventions to prevent later cardiovascular disease. We therefore analyzed measures of vascular structure and function and biomarkers of cardiovascular risk in a sample of young healthy adults. Methods: Pulse-wave velocity (PWV), carotid-intima media thickness (cIMT) and augmentation index (AIX) were measured in 834 healthy non-smokers (ages 18.0-25.9). Emphasis was put on discriminating between individuals having a vascular structure and function associated with a higher or lower risk, and cluster analysis algorithms were employed to assign the subjects into groups based on these vascular measurements. In addition, a vascular status score (VSS) was calculated by summarizing the results according to quintiles of the vascular measurements. The associations between VSS and cardiovascular biomarkers were examined by regression analyses. Results: The cluster analyses did not yield sufficiently distinct clustering (groups of individuals that could be categorized unequivocally as having either a vascular structure and function associated with a higher or lower CVD risk). VSS proved a better classificatory variable. The associations between VSS and biomarkers of cardiovascular risk were analyzed by univariable and multivariable regressions. Only body fat percentage and C-reactive protein (CRP) were independently associated with VSS. Conclusions: A VSS calculation, which integrates PWV, cIMT, and AIX measurements is better suited for cardiovascular risk evaluation in young adults than cluster analyses. The independent associations of VSS with body fat percentage and CRP highlight the decisive role of adiposity and systemic inflammation in early atherosclerotic progression and suggests a subordinate role of insulin and lipid metabolism in this age span.

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Section: Introductionmentioning

confidence: 99%

Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study

Pettersson-Pablo

Cao

Bäckström

et al. 2020

BMC Cardiovasc Disord

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“…Maldonado et al [23] found that PWV could be used to predict cardiovascular outcomes in a low-to-moderate cardiovascular risk population. Pereira et al [24] reported that the combination of PWV with HeartSCORE showed a better discriminative capacity of major cardiovascular events than HeartSCORE alone. To the best of our knowledge, our data first proved the predictive value of PWV in a high-risk CAD population undergoing PCI.…”

Section: Discussionmentioning

confidence: 99%

Combination of pulse wave velocity with clinical factors as a promising tool to predict major adverse cardiac events after percutaneous coronary intervention

Chen

Liu

Wang

et al. 2015

Journal of Cardiology

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“…Large population based studies have demonstrated that arterial stiffness is a strong predictor of CVD or CV events not only in the general population, but also in patients with CVD. 14 15 16 …”

Section: Vascular Agingmentioning

confidence: 99%

Evaluation of Arterial Stiffness by Echocardiography: Methodological Aspects

Cho

Kim

2016

Chonnam Med J

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As humans age, degenerative changes in the arterial structure gradually progress and result in the stiffening of the arteries, which is called arteriosclerosis. Arterial stiffness is now an established risk factor of cardiovascular disease (CVD). This stiffening has adverse effects for both the general population as well as for patients with CVD. Measurements of pulse wave velocity and pulse wave analysis are the two most commonly used methods in the evaluation of arterial stiffness, but these methods just allow indirect measures of arterial stiffness. Echocardiography is the most widely used imaging modality in the evaluation of cardiac structure and function and with recent technical advances, it has become possible to evaluate the structure, function and blood flow hemodynamics of the arteries using echocardiography. In the present review, we will discuss the current status of echocardiography in the evaluation of arterial stiffness, especially focusing on the methodological aspects.

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Aortic pulse wave velocity and HeartSCORE: Improving cardiovascular risk stratification. A sub-analysis of the EDIVA (Estudo de DIstensibilidade VAscular) project

Abstract: The results clearly illustrate the benefits of integrating PWV in the risk assessment strategies, as advocated by HeartSCORE, insofar as it contributes to a better discriminative capacity of global cardiovascular risk, particularly in individuals with low or moderate cardiovascular risk.

Cited by 17 publications

References 27 publications

Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study

Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study

Combination of pulse wave velocity with clinical factors as a promising tool to predict major adverse cardiac events after percutaneous coronary intervention

Evaluation of Arterial Stiffness by Echocardiography: Methodological Aspects

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