Aortic pulse wave velocity is a strong predictor of all – cause and cardiovascular mortality in chronic dialysis patients

Avramovski, Petar; Janakievska, P.; Sotiroski, Kosta; Zafirova-Ivanovska, Beti; Šikole, Aleksandar

doi:10.3109/0886022x.2013.843359

Cited by 24 publications

(25 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In hemodialysis patients, atherosclerotic changes, calcifications, and impaired coronary endothelial function may lead to coronary microvascular and epicardial vascular dysfunction and consequently to chronic myocardial ischemia . Increased aortic stiffness is also very common in these patients and may also contribute to impaired left ventricular function and myocardial ischemia …”

Section: Introductionmentioning

confidence: 99%

Impaired coronary microcirculation is associated with left ventricular diastolic dysfunction in end‐stage chronic kidney disease patients

et al. 2020

View full text Add to dashboard Cite

Introduction: Coronary vascular dysfunction, as assessed by coronary flow reserve (CFR) in the left anterior descending coronary artery, is found in various conditions including end-stage chronic kidney disease (CKD). Currently, we investigated the associations of CFR with echocardiographic indices of systolic and diastolic cardiac function and identified independent predictors of CFR in hemodialysis patients. Methods: End-stage CKD patients treated with hemodialysis (n = 29) without known cardiovascular disease were recruited from a Hemodialysis Unit in Northwestern Greece. A thorough echocardiographic evaluation including CFR measurement following dipyridamole infusion was performed in all participants. Arterial stiffness was assessed by measurement of carotid-femoral pulse wave velocity and aortic augmentation index. Results: The mean age of the patients was 63 years, and mean duration of hemodialysis was 2.9 years. CFR was 1.60 ± 0.37 while dipyridamole caused a significant increase in E' sep , S lat , E' lat , and Stroke volume (P < .05 for all). Independent predictors of CFR were posterior wall thickness (B −0.408, P = .013) and dipyridamole-induced changes in Tei index (B −0.425, P = .007). A severely decreased CFR < 1.5 was observed in 52% of the patients. E/E' ratio (B 10.84, P = .014) was the single independent predictor of severely decreased CFR. Conclusions: In end-stage CKD patients on hemodialysis without known cardiovascular disease, impaired coronary vascular function was prevalent and related to increased left ventricular wall thickness, increased filling pressures, and dipyridamole-induced deteriorated myocardial function independently of the presence of wall-motion abnormalities. Further studies are required to clarify the prognostic role of dipyridamole-induced cardiac changes in hemodialysis patients. K E Y W O R D S coronary flow reserve, diastolic function, echocardiography, end-stage renal disease, left ventricular function | 537 PAPAMICHAIL et AL.

show abstract

Section: Introductionmentioning

confidence: 99%

Impaired coronary microcirculation is associated with left ventricular diastolic dysfunction in end‐stage chronic kidney disease patients

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Increased arterial stiffness has been reported in patients undergoing hemodialysis (HD), and this has been associated with an increased risk of cardiovascular disease. 1 , 2 Therefore, the careful management and evaluation of arterial stiffness in such patients is vital. Brachial–ankle pulse wave velocity (baPWV) has been used as a good marker of arterial stiffness, 3 , 4 and it has shown potential as an effective method to evaluate the extent of peripheral vascular damage.…”

Section: Introductionmentioning

confidence: 99%

Platelet to Lymphocyte Percentage Ratio Is Associated With Brachial–Ankle Pulse Wave Velocity in Hemodialysis

Chen

Lee²,

Huang³

et al. 2016

Medicine

View full text Add to dashboard Cite

Increased arterial stiffness in patients receiving hemodialysis (HD) is highly prevalent and is associated with cardiovascular morbidity and mortality. In HD, inflammation is one of the major causes of increased arterial stiffness. Activation of platelets and decreased lymphocyte percentage (LYMPH%) may exhibit inflammation. The aim of this study is to examine the relationship between platelet to LYMPH% ratio and arterial stiffness in HD patients.A total of 220 patients receiving HD were enrolled in this study. The brachial–ankle pulse wave velocity (baPWV) was measured using an ankle–brachial index form device. Multivariate linear regression analysis was performed to investigate the relations of the platelet to LYMPH% ratio and baPWV.The value of the platelet to LYMPH% ratio was 59.2 ± 33.3 (109 cells/L/%). After multivariate stepwise analysis, diabetes (β: 163.973, P = 0.02), high systolic blood pressure (per 1 mm Hg, β: 9.010, P < 0.001), high platelet to LYMPH% ratio (per 109 cells/L/%, β: 3.334, P < 0.01), and low albumin (per 0.1 mg/dL, β: −55.912, P < 0.001) were independently associated with an increased baPWV. Furthermore, high white blood cells (per 109 cells/L, β: 3.941, P < 0.001), high neutrophil percentage (per 1%, β: 1.144, P < 0.001), and high CRP (per 1 mg/L, β: 9.161, P = 0.03) were independently associated with an increased platelet to LYMPH% ratio.An increased platelet to LYMPH% ratio is associated with an increased baPWV in HD patients. An easy and inexpensive laboratory measure of platelet to LYMPH% ratio may provide an important information regarding arterial stiffness in patients with HD.

show abstract

“…This result confirms previous studies that ESRD patients with higher baPWV rates are prone to develop CVD after KT. [ 8 , 17 ]…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Pre-Transplant Arterial Stiffness and the Impact of Kidney Transplantation on Arterial Stiffness

et al. 2015

View full text Add to dashboard Cite

BackgroundArterial stiffness is closely associated with cardiovascular disease (CVD) in end stage renal disease (ESRD) patients. However, the clinical significance of pre-transplant arterial stiffness and the impact of kidney transplantation (KT) on arterial stiffness have not yet been determined.MethodWe measured the brachial-ankle pulse wave velocity (baPWV) before KT and one year after KT. We evaluated the potential utility of pre-transplant baPWV as a screening test to predict CVD. The impact of KT on progression of arterial stiffness was evaluated according to changes in baPWV after KT. The factors that influence the change of baPWV after KT were also examined.ResultThe mean value of pre-transplant baPWV was 1508 ± 300 cm/s in ESRD patients; 93.4% had a higher baPWV value than healthy controls. Pre-transplant baPWV was higher in patients with CVD than in those without CVD (1800 ± 440 vs. 1491 ± 265 cm/s, p<0.05), and was a strong predictive factor of CVD (OR 1.003, p<0.05). The optimal cut-off value of baPWV for the detection of CVD was 1591 cm/s, and this value was an independent predictor of CVD in KT recipients (OR 6.3, p<0.05). The post-transplant baPWV was significantly decreased compared to that of pre-transplant rates (1418 ± 235 vs. 1517 ± 293 cm/s, p<0.05), and progression of arterial stiffness was not observed in 86.9% patients. Logistic regression analysis revealed that higher body mass index and the degree of increase in calcium levels were independent risk factors that affected baPWV after KT.ConclusionsEvaluation of arterial stiffness with baPWV is a useful screening test for predicting CVD after KT, and KT is effective in preventing the progression of arterial stiffness in ESRD patients.

show abstract

Aortic pulse wave velocity is a strong predictor of all – cause and cardiovascular mortality in chronic dialysis patients

Cited by 24 publications

References 18 publications

Impaired coronary microcirculation is associated with left ventricular diastolic dysfunction in end‐stage chronic kidney disease patients

Impaired coronary microcirculation is associated with left ventricular diastolic dysfunction in end‐stage chronic kidney disease patients

Platelet to Lymphocyte Percentage Ratio Is Associated With Brachial–Ankle Pulse Wave Velocity in Hemodialysis

Clinical Significance of Pre-Transplant Arterial Stiffness and the Impact of Kidney Transplantation on Arterial Stiffness

Contact Info

Product

Resources

About