Aortic smooth muscle cell alterations in mice systemically exposed to arsenic

Chen, Shih‐Chieh; Huang, Shin-Yin; Lin, Wenting; Yang, Rei‐Cheng; Yu, Hsin-Chieh

doi:10.1007/s00380-015-0708-7

Cited by 6 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies indicated that both the mean systolic and diastolic arterial pressures and body weights in mice fed a high arsenic dose (20 mg/kg) were not significantly different from those in control mice 6 , 10 . Our results showed that mice systemically exposed to various doses of arsenic were not significantly different from control mice in terms of growth and behavior, suggesting that arsenic doses of 10-20 mg/kg body weight do not produce any undesirable physiological stress or overt toxicity in ICR mice.…”

Section: Discussionmentioning

confidence: 85%

Vascular Hyperpermeability Response in Animals Systemically Exposed to Arsenic

Chen¹,

Chang²,

Lin³

2018

Int. J. Med. Sci.

Self Cite

View full text Add to dashboard Cite

The mechanisms underlying cardiovascular diseases induced by chronic exposure to arsenic remain unclarified. The objectives of this study were to investigate whether increased vascular leakage is induced by inflammatory mustard oil in mice systemically exposed to various doses of arsenic and whether an increased vascular leakage response is still present in arsenic-fed mice after arsenic discontinuation for 2 or 6 months. ICR mice were fed water or various doses of sodium arsenite (10, 15, or 20 mg/kg/day; 5 days/week) for 8 weeks. In separate experiments, the mice were treated with sodium arsenite (20 mg/kg) for 2 or 8 weeks, followed by arsenic discontinuation for 2 or 6 months. Vascular permeability to inflammatory mustard oil was quantified using Evans blue (EB) techniques. Both arsenic-exposed and water-fed (control) mice displayed similar basal levels of EB leakage in the ears brushed with mineral oil, a vehicle of mustard oil. The levels of EB leakage induced by mustard oil in the arsenic groups fed with sodium arsenite (10 or 15 mg/kg) were similar to those of water-fed mice. However, increased levels of EB leakage in response to mustard oil stimulation were significantly higher in mice treated with sodium arsenite (20 mg/kg; high dose) than in arsenic-fed (10 or 15 mg/kg; low and middle doses) or control mice. After arsenic discontinuation for 2 or 6 months, mustard oil-induced vascular EB leakage in arsenic-fed (20 mg/kg) mice was similar to that in control mice. Dramatic increases in mustard oil-induced vascular leakage were only present in mice systemically exposed to the high arsenic dose, indicating the synergistic effects of the high arsenic dose and mustard oil.

show abstract