Aortic Stenosis Pregnancy and Labour

Vaijyanath, Anita Matai; Garg, Prerna

doi:10.31729/jnma.740

Cited by 2 publications

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“…However, it remains unclear if the RAS is involved in mediating this heart dysfunction. Studies where the RAS has been either blocked by ACE inhibitors or angiotensin receptor antagonists suggest the involvement of the RAS in the regulation of heart function and cardiac hypertrophy [56]. Neither ace, angiotensinogen nor AT1 receptor null mice show any defects in heart development and function [57, for review].…”

Section: The Contribution Of Ace2 To Cardiac Function Ventricular Rementioning

confidence: 99%

Angiotensin converting enzyme-2 (ACE2) and its possible roles in hypertension, diabetes and cardiac function

Warner¹,

Guy

Lambert

et al. 2003

Lett Pept Sci

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Angiotensin converting enzyme-2 (ACE2) is a recently described homologue of the vasoactive peptidase, angiotensin converting enzyme (ACE). Like ACE, ACE2 is an integral (type I) membrane zinc metallopeptidase, which exists as an ectoenzyme. ACE2 is less widely distributed than ACE in the body, being expressed at highest concentrations in the heart, kidney and testis. ACE2 also differs from ACE in its substrate specificity, functioning exclusively as a carboxypeptidase rather than a peptidyl dipeptidase. A key role for ACE2 appears to be emerging in the conversion of angiotensin II to angiotensin (1-7), allowing it to act as a counter-balance to the actions of ACE. ACE2 has been localised to the endothelial and epithelial cells of the heart and kidney where it may have a role at the cell surface in hydrolysing bioactive peptides such as angiotensin II present in the circulation. A role for ACE2 in the metabolism of other biologically active peptides also needs to be considered. ACE2 also serendipitously appears to act as a receptor for the severe acute respiratory syndrome (SARS) coronavirus. Studies using ace2 lmice, and other emerging studies in vivo and in vitro, have revealed that ACE2 has important functions in cardiac regulation and diabetes. Together with its role as a SARS receptor, ACE2 is therefore likely to be an important therapeutic target in a diverse range of disease states.Abbreviations: ACE, angiotensin-converting enzyme; ACE2, angiotensin-converting enzyme-2; Ang, angiotensin; APJ, apelin receptor; AT1, AT2, AT4 (angiotensin receptor type 1,2,4); BK, bradykinin; HEK, Human embryonic kidney; HIV, human immunodeficiency virus; QTL, quantitative trait locus; RAS, renin-angiotensin system; SARS, severe acute respiratory syndrome; SHR, spontaneously hypertensive rat; SHRSP, spontaneously hypertensive rat (stroke-prone).

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Section: The Contribution Of Ace2 To Cardiac Function Ventricular Rementioning

confidence: 99%

Angiotensin converting enzyme-2 (ACE2) and its possible roles in hypertension, diabetes and cardiac function

Warner¹,

Guy

Lambert

et al. 2003

Lett Pept Sci

View full text Add to dashboard Cite

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“…46,47 Less frequently seen diseases during the survey period included natal and perinatal heart problems; however, these conditions account for a significant burden of disease and should not be neglected. [48][49][50] Kawasaki disease has also been previously reported in Nepal 51-53 but was not encountered during the period of survey. In addition, reports have appeared on the cardiovascular effect of atherosclerosis and psychophysiological response in stunted Nepalese children.…”

Section: Pediatric Cardiac Disease In Nepal: a Cross Sectional Surveymentioning

confidence: 84%

Pediatric Cardiology and Children’s Heart Care in Nepal

2004

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Pediatric cardiology is an established sphere of modern medicine; however, Nepal presently has limited facilities and skilled practitioners dedicated to this subspecialty of pediatric medicine. The purpose of this review is to analyze present status of pediatric cardiology and children’s heart care in Nepal. Observation of the children consulted and those admitted to the cardiac unit of Kanti Children’s Hospital (KCH), as well as the review of hospital records and existing scientific literature, have revealed that majority of cardiac diseases afflicting Nepalese children originate from infections that are preventable to a great extent. Congenital heart problems are the second leading source of cardiac disease in the Nepalese pediatric population. In order to develop pediatric cardiology as a successful field in Nepal in the coming years, the major issues to address include: early diagnosis, systematizing long-term antibiotic prophylaxis to patients who require it, improving referral and patient transportation securing, funding for the long hospital stays required, expenditure, training health personnel for the tender pre and post-surgical care, and expanding and improving patient and community heart health education. Several national and international organizations could provide important assistance for controlling the preventable and treatable infections associated with pediatric cardiac disease and heart defects as well as care of children with heart problems.Key Words: Children, congenital heart disease, heart, Nepal, pediatric cardiology, rheumatic heart disease.

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Aortic Stenosis Pregnancy and Labour

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Cited by 2 publications

References 0 publications

Angiotensin converting enzyme-2 (ACE2) and its possible roles in hypertension, diabetes and cardiac function

Angiotensin converting enzyme-2 (ACE2) and its possible roles in hypertension, diabetes and cardiac function

Pediatric Cardiology and Children’s Heart Care in Nepal

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