Aortic stiffness, blood pressure and renal dysfunction

Grassi, Davide; Ferri, Claudio

doi:10.1007/s11739-011-0678-4

Cited by 7 publications

(8 citation statements)

References 28 publications

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“…Moreover, the average energy intake in this study of 824 kcal mimicked a serving size typical for the main meal in Western diets [ 25 , 26 ]. The magnitude of wave reflection and arterial stiffness has been shown to have an independent predictive value for all cause mortality and cardiovascular morbidity, coronary events and strokes in hypertensive patients [ 27 ]. Also, small changes in BP—for instance, due to dietary and lifestyle modificationmay have a significant impact on the prevalence of hypertension and risk of cardiovascular disease [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Black Tea Lowers Blood Pressure and Wave Reflections in Fasted and Postprandial Conditions in Hypertensive Patients: A Randomised Study

et al. 2015

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Hypertension and arterial stiffening are independent predictors of cardiovascular mortality. Flavonoids may exert some vascular protection. We investigated the effects of black tea on blood pressure (BP) and wave reflections before and after fat load in hypertensives. According to a randomized, double-blind, controlled, cross-over design, 19 patients were assigned to consume black tea (129 mg flavonoids) or placebo twice a day for eight days (13 day wash-out period). Digital volume pulse and BP were measured before and 1, 2, 3 and 4 h after tea consumption. Measurements were performed in a fasted state and after a fat load. Compared to placebo, reflection index and stiffness index decreased after tea consumption (p < 0.0001). Fat challenge increased wave reflection, which was counteracted by tea consumption (p < 0.0001). Black tea decreased systolic and diastolic BP (−3.2 mmHg, p < 0.005 and −2.6 mmHg, p < 0.0001; respectively) and prevented BP increase after a fat load (p < 0.0001). Black tea consumption lowers wave reflections and BP in the fasting state, and during the challenging haemodynamic conditions after a fat load in hypertensives. Considering lipemia-induced impairment of arterial function may occur frequently during the day, our findings suggest regular consumption of black tea may be relevant for cardiovascular protection.

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Section: Discussionmentioning

confidence: 99%

Black Tea Lowers Blood Pressure and Wave Reflections in Fasted and Postprandial Conditions in Hypertensive Patients: A Randomised Study

et al. 2015

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“…It has been observed that age‐related arterial stiffness can seriously affect diastolic compliance []. Indeed, renal circulation is unique with respect to transmitted blood pressure fluctuations and arterial stiffness []. As such, low‐grade albuminuria perhaps indicates more arterial functional and hemodynamic alteration in patients younger than 65 years and with duration of diabetes less than 10 years.…”

Section: Discussionmentioning

confidence: 99%

Low‐grade albuminuria associated with brachial‐ankle pulse wave velocity in young adults with type 2 diabetes mellitus in China

Huang

Yang

Zhang

et al. 2014

Diabetes Metabolism Res

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“…Early signs of renal damage, such as microalbuminuria, mildly decreased GFR, and increased renal vascular impedance, are relatively common conditions in patients with AS [44]. For example, diabetes, a powerful risk factor for CVD, is a major risk factor for albuminuria and reduced GFR.…”

Section: Interaction Of As and Kidney Diseasesmentioning

confidence: 99%

“…Diabetes is initially associated with generalized hyperperfusion and microvascular hypertension and is also associated with increased AS [7]. As noted above, increased AS is associated with an increase in the amplitudes of the forward and reflected pressure waves and is therefore associated with CKD [44]. Indeed, renal circulation is unique with respect to transmitted blood pressure fluctuations [45].…”

Section: Interaction Of As and Kidney Diseasesmentioning

confidence: 99%

Arterial Stiffness: A Nexus between Cardiac and Renal Disease

Jia

Aroor

Sowers³

2014

Cardiorenal Med

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Vascular disease is the leading cause of morbidity and mortality in the Western world, and vascular function is determined by structural and functional properties of the arterial vascular wall. Cardiorenal metabolic syndrome such as obesity, diabetes, hypertension, kidney disease, and aging are conditions that predispose to arterial stiffening, which is a pathological alteration of the vascular wall and ultimately results in target organ damage in heart and kidney. In this review, we provide new insights on the interactions between arterial stiffness, vascular resistance and pulse wave velocity as well as final end-organ damage in heart and kidney. Better understanding of the mechanisms of arterial functional and hemodynamic alteration may help in developing more refined therapeutic strategies aimed to reduce cardiovascular and chronic kidney diseases.

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Aortic stiffness, blood pressure and renal dysfunction

Cited by 7 publications

References 28 publications

Black Tea Lowers Blood Pressure and Wave Reflections in Fasted and Postprandial Conditions in Hypertensive Patients: A Randomised Study

Black Tea Lowers Blood Pressure and Wave Reflections in Fasted and Postprandial Conditions in Hypertensive Patients: A Randomised Study

Low‐grade albuminuria associated with brachial‐ankle pulse wave velocity in young adults with type 2 diabetes mellitus in China

Arterial Stiffness: A Nexus between Cardiac and Renal Disease

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