Aortic Stiffness, Inflammation, and Incidence of Cardiovascular Events in Elderly Participants From the General Population

Wadström, Benjamin Nilsson; Persson, Margaretha; Engström, Gunnar; Nilsson, Peter M.

doi:10.1177/00033197211017406

Cited by 8 publications

(6 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PWV measurement is currently the optimal measurement of arterial stiffness because of its accuracy, simplicity, predictive value, and reproducibility. The Malmö Diet and Cancer Study attempted to find the association between PWV and inflammation for CVD risk prediction among elderly participants [ 45 ] and showed that the measurement of PWV can be used as an objective and robust indicator of CVD risk. They suggested that low-grade systemic inflammation might be the missing link between different metabolic phenotypes and CV risk [ 46 ]; this warrants further consideration.…”

Section: Discussionmentioning

confidence: 99%

Association between Brachial-Ankle Pulse Wave Velocity as a Marker of Arterial Stiffness and Body Mass Index in a Chinese Population

Zuo

Tang

O’Rourke

et al. 2022

JCDD

View full text Add to dashboard Cite

Objectives: Arterial stiffness is widely accepted as an important predictor of cardiovascular disease (CVD) development. While obesity is generally associated with increased CVD risk, there is evidence that overweight patients with existing CVD may have better clinical outcomes than their lean counterparts. Our study sought to observe any potential association between brachial–ankle pulse wave velocity (BAPWV), a marker of arterial stiffness related to CVD risk, and Body Mass Index (BMI), a crude and widely used measure of obesity. Methods: Adult individuals (n = 857) assessed for routine CV risk were included and grouped according to their BMI (<25 kg/m2: normal; 25–30 kg/m2: overweight, ≥30 kg/m2: obese). Their anthropometric parameters, brachial cuff pressures, and BAPWV were measured. Results: Brachial pressure was significantly higher as BMI increased. BAPWV showed a positive linear association with systolic (r = 0.66, p < 0.01), mean (r = 0.60, p < 0.01), diastolic (r = 0.51, p < 0.01), and pulse (r = 0.53, p < 0.01) pressures. However, a linear relationship between BMI and BAPWV was only apparent in males aged <50 years (p = 0.01) and in females aged ≥50 years (p < 0.01). In individuals with similar brachial systolic pressure, BAPWV was higher in normal-weight subjects compared to overweight–obese ones. Conclusions: This conflicting finding is attributed to an overestimation of the degree of arterial stiffness as a measure of CVD risk in individuals with a less ‘healthy’ BMI. This suggests that BMI may not the appropriate obesity indicator to assess CV risk. Our finding emphasizes the importance of establishing a non-linear relationship between CVD risk, age, and BMI, taking into account apparent sex differences, to predict future CV events. While this finding may suggest a lower degree of stiffness in large arteries of overweight–obese subjects compared to their normal-weight counterparts, the potential implications for individuals with higher BMI need be explored further.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between Brachial-Ankle Pulse Wave Velocity as a Marker of Arterial Stiffness and Body Mass Index in a Chinese Population

Zuo

Tang

O’Rourke

et al. 2022

JCDD

View full text Add to dashboard Cite

show abstract

“…In a recent study, Wadström et al 30 that PWV and inflammation have had a separate, but additive effect on CVD risk. However, the study population was older compared with that of our study which was a significant limitation for the generalisability of the findings.…”

Section: Discussionmentioning

confidence: 99%

“…In a recent study, Wadström et al 30 analysed the interplay between PWV and inflammation for CVD risk prediction among the elderly participants of the Malmö Diet and Cancer Study cohort. They reported that PWV and inflammation have had a separate, but additive effect on CVD risk.…”

Section: Discussionmentioning

confidence: 99%

The missing link between inflammation and arterial stiffness among different metabolic phenotypes

et al. 2021

View full text Add to dashboard Cite

Obesity is a significant public health problem worldwide because of an increased risk of cardio-metabolic diseases. 1,2 Furthermore, the coronavirus pandemic of 2019 (COVID-19) revealed the importance of the interconnection between obesity, cardio-metabolic diseases, and COVID-19 severity. 3 Nevertheless, some individuals are thought to be protected from the adverse cardiometabolic effects of obesity.These individuals have the designation metabolically healthy obesity (MHO), which means cardiometabolic risk factors other than obesity are absent among their subset. 4 Previously, it was proposed that this metabolic phenotype had a lower risk for cardio-metabolic diseases than estimated based on their body mass index (BMI). 1 However, there are some other contradictory study results regarding all-cause mortality and adverse cardiovascular (CV) outcomes in the MHO phenotype. [5][6][7][8] It has been proposed that metabolic phenotypes with variable fat distribution have different cardio-metabolic disease risks. Two well-known predictors of cardio-metabolic diseases are a lower percentage of lower-body fat mass and a higher percentage of visceral fat mass, the latter of which can be modified by genetic and lifestyle-related factors. 9 Thus, the underlying mechanism for the development of CV disease among different metabolic phenotypes, including MHO, is multifaceted.Arterial stiffness, which can be measured by pulse wave velocity (PWV), is an essential indicator of CV health and an independent predictor for adverse CV outcomes. Thus, it may help us evaluate

show abstract

“…Aortic stiffness is an important risk factor/marker for cardiovascular disease (CVD) and a key element in the pathogenesis of CVD. Growing evidence shows that increased aortic stiffness can predict both cardiovascular mortality and all-cause mortality [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Orthostatic blood pressure adaptations, aortic stiffness, and central hemodynamics in the general population: insights from the Malmö Offspring Study (MOS)

et al. 2022

Self Cite

View full text Add to dashboard Cite

Purpose Arterial stiffness is independently associated with orthostatic hypotension in older individuals. The relationship between orthostatic blood pressure adaptation and aortic stiffness has not been thoroughly examined in a younger population. We investigated the relationship between orthostatic blood pressure adaptations, central aortic hemodynamics, and aortic stiffness in a cohort of predominantly younger and middle-aged adults. Methods We analyzed an observational, population-based study of 5259 individuals living in Malmö, Sweden. We related aortic stiffness and central hemodynamics assessed by carotid–femoral pulse wave velocity and pulse wave analysis at the arteria radialis using Sphygmocor to orthostatic blood pressure adaptation after 3 min standing. Results The mean age of the population was 41.9 ± 14.5 years, and 52.1% were women. We observed the highest aortic stiffness and central aortic blood pressure measurements in the lowest and highest quartiles of orthostatic systolic blood pressure differences (p < 0.001). Aortic stiffness and central aortic blood pressure gradually decreased across increasing quartiles of orthostatic diastolic blood pressure difference (p < 0.001). After full adjustment, orthostatic diastolic blood pressure remained significantly associated with aortic stiffness (p = 0.001) and central aortic blood pressure (p < 0.001), whereas orthostatic systolic blood pressure was significantly associated only with central aortic systolic blood pressure (p = 0.009). No significant associations were found between subclinical orthostatic hypotension, aortic stiffness, and central hemodynamics. Conclusions Our findings demonstrate that altered blood pressure responses to orthostatic challenges, both blood pressure reductions and blood pressure increases, are independently and inversely associated with markers of aortic stiffness (vascular aging) in a predominantly young to middle-aged population.

show abstract

Aortic Stiffness, Inflammation, and Incidence of Cardiovascular Events in Elderly Participants From the General Population

Cited by 8 publications

References 39 publications

Association between Brachial-Ankle Pulse Wave Velocity as a Marker of Arterial Stiffness and Body Mass Index in a Chinese Population

Association between Brachial-Ankle Pulse Wave Velocity as a Marker of Arterial Stiffness and Body Mass Index in a Chinese Population

The missing link between inflammation and arterial stiffness among different metabolic phenotypes

Orthostatic blood pressure adaptations, aortic stiffness, and central hemodynamics in the general population: insights from the Malmö Offspring Study (MOS)

Contact Info

Product

Resources

About