Aortic thrombus in a patient with myeloproliferative thrombocytosis, successfully treated by pharmaceutical therapy: a case report

Yamamoto, Hiroaki; Nishimaki, Haruaki; Imai, Norikazu; Nitta, Masakazu; Daimaru, Osami

doi:10.1186/1752-1947-4-219

Cited by 7 publications

(5 citation statements)

References 13 publications

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“…It is known that myeloproliferative disorders increase the risk of venous thrombosis, but arterial thrombosis is rare [ 19 ]. Lower extremity ischemia secondary to arterial thrombosis with prothrombin gene mutation and myeloproliferative disorders has been established, but not central arterial thrombus [ 20 , 21 ]. The complex interaction between hypercoagulable states and thrombosis warrants additional investigation for coagulopathies, myeloproliferative disorders, and malignancies regarding their role in TAMT.…”

Section: Discussionmentioning

confidence: 99%

A Case of Thoracic Aortic Mural Thrombus and Multiple Hypercoagulable Etiologies

Wagner,

Lantz

2024

Cureus

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Thoracic aortic mural thrombi (TAMT) are rare yet a significant cause of emboli and mortality. Hypercoagulability is thought to play a role in pathogenesis. A common association is prothrombin G20210A mutation. We present a case of an 87-year-old man with an incidentally found TAMT in the setting of prothrombin mutation, metastatic prostate cancer, and a myeloproliferative disorder. The patient had several causes activating Virchow's hypercoagulability principle, contributing to a centrally located clot. Because of its paucity in the literature, we advocate for further research concerning treatment modalities of TAMTs as well as an additional and timely workup for hypercoagulable states to prevent further calamity.

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Section: Discussionmentioning

confidence: 99%

A Case of Thoracic Aortic Mural Thrombus and Multiple Hypercoagulable Etiologies

Wagner,

Lantz

2024

Cureus

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“…Additionally, Lorelli and Shepard reported resolution of abdominal pain in an elderly patient with ET-related thrombosis of the aorta, splenic infarction, and portal vein thrombosis treated with anegralide and systemic anticoagulation with warfarin [3]. In a patient with myelodysplastic syndrome and/or myeloproliferative disorder unclassifiable (MDS/MPD-U) complicated by myeloproliferative thrombocytosis and aortic thrombosis, treatment with low-dose aspirin, hydroxyurea, and ticlopidine, a platelet adenosine diphosphate (ADP) receptor P2Y 12 inhibitor, resulted in complete resolution of the thrombus on CT scan after one week of therapy [15].…”

Section: Discussionmentioning

confidence: 99%

Essential Thrombocythemia Complicated by Occlusive Thrombosis of the Abdominal Aorta

Geringer

Fenderson

Osswald

2019

Case Reports in Hematology

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Introduction. Essential thrombocythemia (ET) is a myeloproliferative neoplasm of excessive platelet production complicated by thrombohemorrhagic events. Thrombosis typically occurs in small to medium vessels; thrombosis of large vessels is rare. Case Presentation. A 75-year-old woman with ET complicated by bilateral retinal vein occlusion was evaluated for fatigue, early satiety, and unintentional weight loss. Her hypertension was well controlled, and her chronic lower extremity claudication from peripheral artery disease was stable. She reported adherence to aspirin 81 mg and hydroxyurea 1000 mg daily, and her platelets (375 × 109/L) were at goal. Bone marrow biopsy was consistent with ET without progression to myelofibrosis or leukemia. CT abdomen demonstrated complete occlusion of the infrarenal aorta, extending into the common iliac arteries, with reconstitution of flow distally via collaterals. The addition of clopidogrel, for platelet inhibition, and cilostazol, for claudication, caused symptom improvement without further thrombosis or bleeding. Discussion. There are few published reports of ET complicated by aortic thrombosis. To our knowledge, this is the first report of aortic thrombosis occurring in an ET patient with normal platelet count on antiplatelet and cytoreductive therapies. There is limited evidence to guide treatment, but medical management with triple antiplatelet therapy may be effective in selected patients.

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“…However, pharmacological therapy is also an auxiliary treatment option for this disease. [ 4 ] Doctors and patients are increasingly opting for endovascular therapy due to minor trauma, less complications, no requirement for general anesthesia or abdominal incisions, and shorter hospitalization duration. [ 5 ]…”

Section: Discussionmentioning

confidence: 99%

Saddle embolism treated by thrombolysis and thrombus aspiration via bilateral femoral artery puncture catheter

Min

Zhang²

2018

Medicine

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Introduction:Abdominal aortic saddle embolism is a rare and severe disease with the manifestation of abrupt onset, rapid progression and high mortality. Endovascular therapy becomes a new option for this disease due to its minor trauma, less complications, no requirement for general anesthesia or abdominal incisions, and shorter hospitalization duration.Methods:A 50-year-old female was diagnosed as abdominal aortic saddle embolism, and thrombus aspiration was given immediately via bilateral femoral artery puncture catheter along with artery indwelling catheter thrombolysis.Results:The saddle embolism was removed completely. After 1-month follow-up, the computed tomography angiography (CTA) examination showed neither stenosis nor thrombus in the abdominal aorta and iliac artery. The patient achieved perfect outcome.Conclusions:Endovascular therapy may be an optional solution for saddle embolism.

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Aortic thrombus in a patient with myeloproliferative thrombocytosis, successfully treated by pharmaceutical therapy: a case report

Cited by 7 publications

References 13 publications

A Case of Thoracic Aortic Mural Thrombus and Multiple Hypercoagulable Etiologies

A Case of Thoracic Aortic Mural Thrombus and Multiple Hypercoagulable Etiologies

Essential Thrombocythemia Complicated by Occlusive Thrombosis of the Abdominal Aorta

Saddle embolism treated by thrombolysis and thrombus aspiration via bilateral femoral artery puncture catheter

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