“…Bioprostheses are less susceptible to early infection, which is often restricted to the leaflets, making cure with antibiotics more likely but increasing the chances of late failure due to degeneration of the cusps. [27,28,29] Bleeding event -Formerly classified as anti-coagulant hemorrhage, a bleeding event is an episode of major internal or external bleeding that causes death, hospitalization, and permanent injury or requires transfusion. This definition applies to all patients, irrespective of anticoagulation status.…”