Aortoiliac Thrombosis in Antiphospholipid Syndrome

Abstract

Antiphospholipid syndrome is accepted as one of the most important causes of hypercoagulable states. Thrombotic events in patients with antiphospholipid syndrome, predominantly women, occur at a younger age than in those suffering from atherosclerotic disease. The majority of the thrombotic events affect the deep venous system of the lower limbs and arterial thrombosis predominates in the cerebral territory. The use of anticoagulant therapy prevents recurrent thrombosis but the duration and intensity of treatment remain controversial. Aortic disease is an anecdotal fact in the literature. A case of infrarenal aortic occlusion involving both iliac arteries associated with primary antiphospholipid syndrome is presented.

Chronic abdominal aortic occlusive disease related to antiphospholipid syndrome: a rare presentation

“… 7 20 Alfayate et al report a case of a young woman with APS who developed a total occlusion of the infrarenal aorta and bilateral iliac arteries. 21 Karaolanis et al have reviewed all 12 sporadic cases of aortic lesions related to APS. The lesions mainly affect middle-aged patients, and most of them receive surgical or interventional treatment.…”

Catastrophic antiphospholipid syndrome presenting with aortic barrage: case report and review of the literature

“…Acute aorto-iliac occlusion is a relatively rare macrovascular thrombotic condition that typically occurs in patients with multiple cardiovascular risk factors. 5 Eleven cases of aortic barrage have been reported in association with aPL so far 6–13 including two unpublished cases (Table 1). The female to male ratio is 1.2:1, with a mean age at onset of 42.5 years, reflecting the epidemiological distribution of APS.…”

Successful Endovascular Treatment for Aortic Thrombosis Due to Primary Antiphospholipid Syndrome: A Case Report and Literature Review

“…To the best of our knowledge, only 14 cases have been reported in the literature (Table 1). [5][6][7][8][9][10][11][12][13][14][15][16][17] Among the 11 cases in which details were described, the most common lesion site was the infrarenal aorta. Regarding the treatment strategy, surgical options, including bypass-grafting or endarterectomy, were performed in 7 cases and thrombolysis in 2.…”