AP-1 family transcription factors: a diverse family of proteins that regulate varied cellular activities in classical hodgkin lymphoma and ALK+ ALCL

Wu, Zuoqiao; Nicoll, Mary; Ingham, Robert J.

doi:10.1186/s40164-020-00197-9

Cited by 66 publications

(49 citation statements)

References 147 publications

(228 reference statements)

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“…CXCLs facilitate angiogenesis and other pathways to promote tumor cells to obtain different proliferation and metastasis potentials 39 . Third, AP-1 family transcription factors regulate a variety of cellular activities in classical Hodgkin's lymphoma and anaplastic large cell lymphoma 40 . Whether CXCLs and their associated genes also promote tumor proliferation, inhibit apoptosis, and evade host immune responses through the AP-1 and NF-κB pathways remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of the expression and significance of CXCLs in human diffuse large B-cell lymphoma

Zhou

Guo

Shi

2022

Sci Rep

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CXCL chemokines (CXCLs) are small cytokines or signal proteins secreted by cells that have been proven to be linked to the occurrence and development of many kinds of cancer. However, the expression and diagnostic and prognostic value of CXCLs in diffuse large B-cell lymphoma (DLBCL) remain to be further studied. We obtained CXCL transcription and survival data of patients with DLBCL from Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), The Cancer Genome Atlas (TCGA), TIMER and cBioPortal databases. R software, STRING and EXCEL were used to process the data. This study discovered that the expression levels of CXCL9-14 in DLBCL were higher than those in normal tissues, while CXCL4, CXCL7 and CXCL8 were lower in tumor than in normal tissues. The expression levels of CXCL2, CXCL10 and CXCL11 were related to tumor stage. CXCL9-14 could be used as an auxiliary molecular marker for the diagnosis of DLBCL. CXCL17 might be a potential prognostic marker of DLBCL.

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Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of the expression and significance of CXCLs in human diffuse large B-cell lymphoma

Zhou

Guo

Shi

2022

Sci Rep

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“…AP1 regulates gene expression in response to various stimuli such as cytokines, growth factors and stress signals. In ALK+ sALCLs AP1 fosters proliferation and survival via PI3K/Akt signaling and immune evasion by promoting program death-ligand 1 (PD-L1) transcription [ 56 ]. We have previously shown that PD-L1 expression, observed in more than 50% of BI-ALCL cases, was associated with copy number alterations at chromosome 9p24.1 in only 33% of the cases, suggesting the involvement of additional mechanisms in its upregulation [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

RNA Sequencing of Primary Cutaneous and Breast-Implant Associated Anaplastic Large Cell Lymphomas Reveals Infrequent Fusion Transcripts and Upregulation of PI3K/AKT Signaling via Neurotrophin Pathway Genes

Napoli

Vacca

Bertolazzi

et al. 2021

Cancers

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Cutaneous and breast implant-associated anaplastic large-cell lymphomas (cALCLs and BI-ALCLs) are two localized forms of peripheral T-cell lymphomas (PTCLs) that are recognized as distinct entities within the family of ALCL. JAK-STAT signaling is a common feature of all ALCL subtypes, whereas DUSP22/IRF4, TP63 and TYK gene rearrangements have been reported in a proportion of ALK-negative sALCLs and cALCLs. Both cALCLs and BI-ALCLs differ in their gene expression profiles compared to PTCLs; however, a direct comparison of the genomic alterations and transcriptomes of these two entities is lacking. By performing RNA sequencing of 1385 genes (TruSight RNA Pan-Cancer, Illumina) in 12 cALCLs, 10 BI-ALCLs and two anaplastic lymphoma kinase (ALK)-positive sALCLs, we identified the previously reported TYK2-NPM1 fusion in 1 cALCL (1/12, 8%), and four new intrachromosomal gene fusions in 2 BI-ALCLs (2/10, 20%) involving genes on chromosome 1 (EPS15-GNG12 and ARNT-GOLPH3L) and on chromosome 17 (MYO18A-GIT1 and NF1-GOSR1). One of the two BI-ALCL samples showed a complex karyotype, raising the possibility that genomic instability may be responsible for intra-chromosomal fusions in BI-ALCL. Moreover, transcriptional analysis revealed similar upregulation of the PI3K/Akt pathway, associated with enrichment in the expression of neurotrophin signaling genes, which was more conspicuous in BI-ALCL, as well as differences, i.e., over-expression of genes involved in the RNA polymerase II transcription program in BI-ALCL and of the RNA splicing/processing program in cALCL.

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“…In this context, AP-1 is another important transcription factor which is mainly involved in cell survival and proliferation [ 71 , 72 ]. Interestingly, PN has been shown to inhibit AP-1 DNA binding and transcriptional activity induced by UVB in a skin cancer model, thus exerting a chemopreventive activity [ 73 ].…”

Section: The Effect Of Parthenolide On Gene Expression Profilementioning

confidence: 99%

Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties

et al. 2022

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Due to its chemical properties and multiple molecular effects on different tumor cell types, the sesquiterpene lactone parthenolide (PN) can be considered an effective drug with significant potential in cancer therapy. PN has been shown to induce either classic apoptosis or alternative caspase-independent forms of cell death in many tumor models. The therapeutical potential of PN has been increased by chemical design and synthesis of more soluble analogues including dimethylaminoparthenolide (DMAPT). This review focuses on the molecular mechanisms of both PN and analogues action in tumor models, highlighting their effects on gene expression, signal transduction and execution of different types of cell death. Recent findings indicate that these compounds not only inhibit prosurvival transcriptional factors such as NF-kB and STATs but can also determine the activation of specific death pathways, increasing intracellular reactive oxygen species (ROS) production and modifications of Bcl-2 family members. An intriguing property of these compounds is its specific targeting of cancer stem cells. The unusual actions of PN and its analogues make these agents good candidates for molecular targeted cancer therapy.

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AP-1 family transcription factors: a diverse family of proteins that regulate varied cellular activities in classical hodgkin lymphoma and ALK+ ALCL

Cited by 66 publications

References 147 publications

Comprehensive analysis of the expression and significance of CXCLs in human diffuse large B-cell lymphoma

Comprehensive analysis of the expression and significance of CXCLs in human diffuse large B-cell lymphoma

RNA Sequencing of Primary Cutaneous and Breast-Implant Associated Anaplastic Large Cell Lymphomas Reveals Infrequent Fusion Transcripts and Upregulation of PI3K/AKT Signaling via Neurotrophin Pathway Genes

Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties

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