Apathy, cognitive deficits and functional impairment in schizophrenia

Konstantakopoulos, George; Ploumpidis, D; Oulis, Panagiotis; Patrikelis, Panayiotis; Soumani, A.; Papadimitriou, George N.; Politis, Antonis

doi:10.1016/j.schres.2011.07.003

Cited by 133 publications

(91 citation statements)

References 44 publications

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“…In partial contrast to our data, studies have suggested that motivational deficits (i.e., apathy) in schizophrenia are linked to cognitive deficits (Fervaha et al, 2014a,b;Roth et al, 2004), especially to deficits in executive functions (Faerden et al, 2009;Konstantakopoulos et al, 2011). In the present study, the correlation between apathy and composite cognition failed to reach significance.…”

Section: Discussioncontrasting

confidence: 99%

The association of neurocognitive impairment with diminished expression and apathy in schizophrenia

Hartmann-Riemer

Hager

Kirschner

et al. 2015

Schizophrenia Research

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Negative symptoms can be grouped into the two dimensions of diminished expression and apathy, which have been shown to be dissociable regarding external validators, such as functional outcome. Here, we investigated whether these two dimensions differentially relate to neurocognitive impairment in schizophrenia. 47 patients with schizophrenia or schizoaffective disorder and 33 healthy control participants were subjected to a neurocognitive test battery assessing multiple cognitive domains (processing speed, working memory, verbal fluency, verbal learning and memory, mental planning), which are integrated into a composite cognition score. Negative symptoms in patients were assessed using the Brief Negative Symptom Scale. We found that diminished expression significantly related to neurocognitive impairment, while severity of apathy symptoms was not directly associated with neurocognition. Other assessed clinical variables include chlorpromazine equivalents, positive symptoms, and depressive symptoms and did not influence the results. Our results are in line with a cognitive resource limitation model of diminished expression in schizophrenia and indicate that cognitive remediation therapy might be helpful to ameliorate expressive deficits.

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Section: Discussioncontrasting

confidence: 99%

The association of neurocognitive impairment with diminished expression and apathy in schizophrenia

Hartmann-Riemer

Hager

Kirschner

et al. 2015

Schizophrenia Research

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“…Hedonic deficits are also significantly associated with healthrelated quality of life (Ritsner et al, 2011). With amotivation, evidence suggests that motivational deficits may be an important determinant of functional disability (Konstantakopoulos et al, 2011;Reddy et al, 2015), possibly attributable to difficulties in perceiving reward outcomes (Gard et al, 2014), and effort-based decision making . This argument is supported by the recent finding that amotivation, but not expressive deficits, have been found to be associated with impairments in integrating rewards with effortful behaviour during decision making (Hartmann et al, 2015).…”

Section: Comparison With the Literaturementioning

confidence: 99%

The relationship between experiential deficits of negative symptoms and subjective quality of life in schizophrenia

Savill

Orfanos

Reininghaus

et al. 2016

Schizophrenia Research

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“…This result is not surprising as executive dysfunction has been involved in apathetic manifestations in Parkinson's disease (Pagonabarraga et al 2015), Alzheimer's disease ( L a n d e s e t a l . 2 0 0 1 ) , a n d s c h i z o p h r e n i a (Konstantakopoulos et al 2011). Disturbance in executive functioning could lead to lack of cognitive flexibly, notably difficulties in modifying intentions according to the environmental demands, which in turn lead healthy older adults to drop their current action increasing apathy.…”

Section: Discussionmentioning

confidence: 99%

“…In these neurologic disorders, apathy has been constantly associated with functional impairments (Jorge et al 2010;Landes et al 2001), caregiver burden, anxiety, and depression (Ishii et al 2009;Lou et al 2015). Thus, whatever the pathology (Konstantakopoulos et al 2011), apathy constitutes a fundamental target for pharmacological and psychosocial interventions, because it has a negative impact on rehabilitation effort. However, interventions for this frequent behavioral condition have provided limited evidence of efficacy (Drijgers et al 2009;Rea et al 2014).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the exploration of apathy in normal aging remains mostly descriptive, and in contrast to neurodegenerative or acquired neurological diseases, its underlying components are poorly understood. From a transdiagnostic perspective, several psychological components appear involved in apathy in both neurological diseases and psychiatric disorders, notably cognitive impairments such as executive dysfunctioning (Konstantakopoulos et al 2011), depression (see Arnould et al 2013 for a review), sensitivity to reward (Rochat et al 2013), anticipatory pleasure (Jordan et al 2013), and global and physical activity (Telenius et al 2015).…”

Section: Introductionmentioning

confidence: 99%

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Multidimensional model of apathy in older adults using partial least squares—path modeling

Raffard¹,

Bortolon²,

Burca³

et al. 2016

AGE

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Apathy defined as a mental state characterized by a lack of goal-directed behavior is prevalent and associated with poor functioning in older adults. The main objective of this study was to identify factors contributing to the distinct dimensions of apathy (cognitive, emotional, and behavioral) in older adults without dementia. One hundred and fifty participants (mean age, 80.42) completed self-rated questionnaires assessing apathy, emotional distress, anticipatory pleasure, motivational systems, physical functioning, quality of life, and cognitive functioning. Data were analyzed using partial least squares variance-based structural equation modeling in order to examine factors contributing to the three different dimensions of apathy in our sample. Overall, the different facets of apathy were associated with cognitive functioning, anticipatory pleasure, sensitivity to reward, and physical functioning, but the contribution of these different factors to the three dimensions of apathy differed significantly. More specifically, the impact of anticipatory pleasure and physical functioning was stronger for the cognitive than for emotional apathy. Conversely, the impact of sensibility to reward, although small, was slightly stronger on emotional apathy. Regarding behavioral apathy, again we found similar latent variables except for the cognitive functioning whose impact was not statistically significant. Our results highlight the need to take into account various mechanisms involved in the different facets of apathy in older adults without dementia, including not only cognitive factors but also motivational variables and aspects related to physical disability. Clinical implications are discussed.

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Apathy, cognitive deficits and functional impairment in schizophrenia

Cited by 133 publications

References 44 publications

The association of neurocognitive impairment with diminished expression and apathy in schizophrenia

The association of neurocognitive impairment with diminished expression and apathy in schizophrenia

The relationship between experiential deficits of negative symptoms and subjective quality of life in schizophrenia

Multidimensional model of apathy in older adults using partial least squares—path modeling

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