Apathy in first episode psychosis patients: A ten year longitudinal follow-up study

Evensen, Julie; Røssberg, Jan Ivar; Barder, Helene Eidsmo; Haahr, Ulrik; Hegelstad, Wenche ten Velden; Joa, Inge; Johannessen, Jan Olav; Larsen, Tor Ketil; Melle, Ingrid; Opjordsmoen, Stein; Rund, Bjørn Rishovd; Simonsen, Erik; Vaglum, Per; Friis, Svein; McGlashan, Thomas H.

doi:10.1016/j.schres.2011.12.019

Cited by 69 publications

(62 citation statements)

References 46 publications

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“…A worse global functioning after 1 year of treatment and poor daily functioning in first-episode patients with PNS was consistently reported, demonstrating that early in the course of the illness PNS predict poor psychosocial functioning (Milev et al, 2005;Evensen et al, 2012;Galderisi et al, 2013b;Chang et al, 2013;Ventura et al, 2015).…”

Section: Course and Outcomementioning

confidence: 93%

Primary and persistent negative symptoms: Concepts, assessments and neurobiological bases

Mucci

Merlotti

Üçok

et al. 2017

Schizophrenia Research

115

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Section: Course and Outcomementioning

confidence: 93%

Primary and persistent negative symptoms: Concepts, assessments and neurobiological bases

Mucci

Merlotti

Üçok

et al. 2017

Schizophrenia Research

115

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“…[3][4][5] Apathy, considered as a core component of negative symptoms 6,7 can be defined as a quantitative reduction of voluntary goal-directed behaviors, 8 and outside the schizophrenia literature has been the subject of fundamental research interest in neurological disorders such as Parkinson disease, brain injury and Alzheimer Disease. 1,9 In spite of the strong negative impact of apathy related symptoms in schizophrenia, 7 treatment studies for this frequent behavioral condition have provided limited evidence of efficiency.…”

Section: Introductionmentioning

confidence: 99%

Working Memory Deficit as a Risk Factor for Severe Apathy in Schizophrenia: A 1-Year Longitudinal Study

Raffard

Gutierrez

Yazbek

et al. 2016

SCHBUL

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Apathy, described as impaired motivation and goal-directed behavior, is a common yet often overlooked multidimensional psychopathological state in schizophrenia. Its underlying cognitive processes remain largely unexplored. Data was drawn from a longitudinal hospital study of patients with a DSM-IV diagnosis of schizophrenia; 137 (82.5%) participated at the 1-month follow-up and 81 (59.1%) at the 1-year follow-up. Apathy was assessed with the Lille Apathy Rating Scale, validated in French and in schizophrenia. Severe apathy, overall (total score > −13) and on 4 previously identified distinct dimensions, was considered. Episodic verbal learning was assessed with the California Verbal Learning Test, executive functioning with the Trail Making Test, the Six Element Test and the Stop Signal Paradigm and working memory with the Letter-Number Sequencing Test. After controlling for confounding variables, only episodic verbal learning was associated with severe overall apathy in the cross-sectional study. At 1 year, working memory was associated with an increased risk of severe overall apathy, adjusting for baseline apathy. Using a dimensional approach to apathy, specific types of cognition were found to be associated with specific dimensions of apathy. Our findings confirm the need for a multidimensional approach of negative symptoms in schizophrenia. Moreover, cognitive functioning could be a risk factor for developing severe apathy. Cognitive remediation may thus be a useful non-pharmacological intervention for treating apathy in schizophrenia patients.

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“…In the TIPS (Early Treatment and Intervention in Psychosis) FEP cohort, 30% of patients showed clinical levels of apathy when assessed ten years after the first psychotic episode and its presence was related to impaired functioning and poorer subjective quality of life [106].…”

Section: Negative Symptoms and Psychosocial Functioningmentioning

confidence: 99%

Untitled

2016

IJCNMH

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Although functional recovery could be advocated as an achievable treatment goal, many effective interventions for the treatment of psychotic symptoms, such as antipsychotic drugs, may not improve functioning. The last two decades of cognitive and clinical research on schizophrenia were a turning point for the firm acknowledgment of how relevant social cognitive deficits and negative symptoms could be in predicting psychosocial functioning. The relevance of social cognition dysfunction in schizophrenia patients' daily living is now unabated. In fact, social cognition deficits could be the most significant predictor of functionality in patients with schizophrenia, non-redundantly with neurocognition. Emerging evidence suggests that negative symptoms appear to play an indirect role, mediating the relationship between neurocognition and social cognition with functional outcomes. Further explorations of this mediating role of negative symptoms have revealed that motivational deficits appear to be particularly important in explaining the relationship between both neurocognitive and social cognitive dysfunction and functional outcomes in schizophrenia. In this paper we will address the relative contribution of two key constructs-social cognitive deficits and negative symptoms, namely how intertwined they could be in daily life functioning of patients with schizophrenia.

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Apathy in first episode psychosis patients: A ten year longitudinal follow-up study

Cited by 69 publications

References 46 publications

Primary and persistent negative symptoms: Concepts, assessments and neurobiological bases

Primary and persistent negative symptoms: Concepts, assessments and neurobiological bases

Working Memory Deficit as a Risk Factor for Severe Apathy in Schizophrenia: A 1-Year Longitudinal Study

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