Apathy Mediates Cognitive Difficulties in Geriatric Depression

Funes, Cynthia; Lavretsky, Helen; Ercoli, Linda M.; Cyr, Natalie St.; Siddarth, Prabha

doi:10.1016/j.jagp.2017.06.012

Cited by 34 publications

(26 citation statements)

References 41 publications

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“…Apathy may be more likely to occur in those with frontal lobe deficits (Brodaty et al, 2005). Increased apathy is found to mediate the relationship between cognition and depression (Funes et al, 2018). Apathy is the most common and persistent neuropsychiatric symptom in AD patients, occurring in 55% of dementia patients (Aalten et al, 2007), which is a prevalent neuropsychiatric manifestation in individuals with AD.…”

Section: Apathy: a More Important Indicatormentioning

confidence: 99%

Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives

2020

Front. Aging Neurosci.

203

157

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Objective: Mild cognitive impairment (MCI) is an important risk state for dementia, particularly Alzheimer's disease (AD). Depression, anxiety, and apathy are commonly observed neuropsychiatric features in MCI, which have been linked to cognitive and functional decline in daily activities, as well as disease progression. Accordingly, the study's objective is to review the prevalence, neuropsychological characteristics, and conversion rates to dementia between MCI patients with and without depression, anxiety, and apathy.Methods: A PubMed search and critical review were performed relating to studies of MCI, depression, anxiety, and apathy.Results: MCI patients have a high prevalence of depression/anxiety/apathy; furthermore, patients with MCI and concomitant depression/anxiety/apathy have more pronounced cognitive deficits and progress more often to dementia than MCI patients without depression/anxiety/apathy. Conclusions and Implications: Depression, anxiety, and apathy are common in MCI and represent possible risk factors for cognitive decline and progression to dementia. Further studies are needed to better understand the role and neurobiology of depression, anxiety, and apathy in MCI.

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Section: Apathy: a More Important Indicatormentioning

confidence: 99%

Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives

2020

Front. Aging Neurosci.

203

157

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“…19 In the elderly, depressive disorders have also been associated with cognitive deficits after mood symptom remission. 20,21 Interestingly, cognitive impairment seems to be mediated by apathy in elderly subjects with MDD as in neurodegenerative diseases like AD and Parkinson's disease. 21 There is considerable overlap in clinical presentation, neuropsychological performance and even neuroimaging findings between elderly patients with depressive disorders and patients with dementia.…”

Section: Depressive Disorders In the Elderly And Cognitive Deficit: Tmentioning

confidence: 99%

“…20,21 Interestingly, cognitive impairment seems to be mediated by apathy in elderly subjects with MDD as in neurodegenerative diseases like AD and Parkinson's disease. 21 There is considerable overlap in clinical presentation, neuropsychological performance and even neuroimaging findings between elderly patients with depressive disorders and patients with dementia. 7 The differential diagnosis of these two conditions can be challenging, requiring careful clinical follow-up with neuropsychological assessment and, if availabe, CSF and PET neuroimaging tests.…”

Section: Depressive Disorders In the Elderly And Cognitive Deficit: Tmentioning

confidence: 99%

Depressive disorders in the elderly and dementia: An update

Dias

Barbosa

Kuang

et al. 2020

Dement. neuropsychol.

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The relationship between depressive disorders in the elderly and dementia, particularly Alzheimer's disease (AD), is highly complex. While the nature of this relationship is still a matter of debate, differential diagnosis and treatment remain a great clinical challenge. We review recent findings on the conundrum of depressive disorders in the elderly and AD. There is a biological continuum between depressive disorders in the elderly -or at least a subgroup of them -and AD. While elderly subjects with depression and patients with AD exhibit higher circulating levels of pro-inflammatory molecules and lower BDNF than matched controls, CSF levels of Aβ42 can discriminate AD from depressive disorders in the elderly. The role of antidepressant treatment as a strategy to minimize the risk of AD remains to be established. A relação entre transtornos depressivos em idosos e demência, particularmente a doença de Alzheimer (DA), é altamente complexa. Embora a natureza desse relacionamento ainda seja motivo de debate, o diagnóstico e o tratamento diferenciais continuam sendo um grande desafio clínico. Revisamos descobertas recentes sobre o dilema de transtornos depressivos em idosos e DA. Existe um contínuo biológico entre os transtornos depressivos em idosos -ou pelo menos um subgrupo deles -e a DA. Enquanto indivíduos idosos com depressão e pacientes com DA exibem níveis circulantes mais altos de moléculas pró-inflamatórias e menor BDNF do que os controles correspondentes, os níveis de Aβ42 no LCR podem discriminar a DA de distúrbios depressivos em idosos. O papel do tratamento antidepressivo como estratégia para minimizar o risco de DA ainda precisa ser estabelecido. Palavras-chave: depressão, demência, Alzheimer, diagnóstico diferencial, terapêutica.

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“…Moreover, it should be noted that perception of self‐efficacy and the concept of cognitive reserve may act as protective factors against cognitive decline and as mediators of depressive symptoms . Likewise, apathy can have a negative impact on the relationship between cognition and depression …”

Section: Introductionmentioning

confidence: 99%

“…20,21 Likewise, apathy can have a negative impact on the relationship between cognition and depression. 22 With respect to sociodemographic variables, older age, 1,23 female gender, 1,24 and not being married [25][26][27] are related to lower cognitive status. In addition, loneliness is associated with increased depressive symptoms and lower cognitive performance.…”

mentioning

confidence: 99%

Cognition and its association with the factors of the EURO‐D: Suffering and Motivation. Findings from SHARE Wave 6

Portellano-Ortiz

Conde-Sala

2018

Int J Geriat Psychiatry

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Apathy Mediates Cognitive Difficulties in Geriatric Depression

Abstract: The findings imply that increased apathy mediates the relationship between cognition and depression. The identification of mediating effects may inform future treatment strategies and preventive interventions that can focus on decreasing apathy to improve cognition in late-life depression.

Cited by 34 publications

References 41 publications

Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives

Depression, Anxiety, and Apathy in Mild Cognitive Impairment: Current Perspectives

Depressive disorders in the elderly and dementia: An update

Cognition and its association with the factors of the EURO‐D: Suffering and Motivation. Findings from SHARE Wave 6

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