Apelin administration improves insulin sensitivity in overweight men during hyperinsulinaemic‐euglycaemic clamp

Gourdy, Pierre; Cazals, L.; Thalamas, Claire; Sommet, Agnès; Calvas, Fabienne; Galitzky, Monique; Vinel, Claire; Dray, Cédric; Hanaire, H.; Castan-Laurell, Isabelle; Valet, Philippe

doi:10.1111/dom.13055

Cited by 52 publications

(38 citation statements)

References 20 publications

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“…Apelin was first reported in 1998 (Tatemoto et al, 1998); the functions of apelin and its receptor were well investigated in mammals. As an adipokine, the studies of apelin and its receptor were mainly focused on energy metabolism (Gourdy et al, 2018;Tekin et al, 2017), cardiac contractility (Gerbier et al, 2017;Gunter et al, 2017;Ni et al, 2017), apoptosis or inflammation (Han et al, 2017;Hoffmann et al, 2017). To clarify the functional roles of apelin/apj in teleost, firstly, we isolated and characterized the apelin and apjs genes from the common carp.…”

Section: Discussionmentioning

confidence: 99%

“…The apelin/apj system plays important and various roles in the physiology and pathophysiology of many organs, including the regulation of blood pressure (Chen et al, 2003), cardiac contractility (Gerbier et al, 2017;Gunter et al, 2017;Ni, Liu, Ge, Zhu, & Zhang, 2017), angiogenesis (Masri, Morin, Cornu, Knibiehler, & Audigier, 2004), metabolic balance (Gourdy et al, 2018;Tekin et al, 2017) and cell proliferation (Kleinz & Davenport, 2005), apoptosis or inflammation (Han, Englander, Gomez, & Greeley, 2017;Hoffmann, Fiedor, & Ptak, 2017).…”

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confidence: 99%

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Apelin and apj in common carp ( Cyprinus carpio L.): Molecular characterization, tissue expression and responses to periprandial changes and fasting–refeeding

et al. 2020

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Apelin and its receptor apj have a variety of biological functions and are involved in appetite and energy regulation. However, the comparative studies of apelin/apj system in fish are still absent. In this study, the open reading frames of apelin and apja and apjb were obtained. Apelin and apj mRNAs were widely distributed in all tissues detected, with the highest level in the brain, followed by the spleen, kidney and foregut. The mRNA expression of apelin and apjs increased rapidly at mealtime and significantly decreased after 30 min of feeding. In addition, there were obvious circadian rhythms (higher at nighttime and lower at daytime) in the expression of apelin and apja and apjb. Furthermore, fasting elevated the mRNA levels of apelin and apjs in the hypothalamus, foregut and hepatopancreas. When the 8‐day fasted fish were refed, apelin and apjs mRNA expression significantly decreased. However, there were differences in the response to fasting and refeeding between apja and apjb. The roles of apelin and its receptor apjs in fish are poorly understood. Herein, we employed molecular and physiological studies to characterize their structures, distribution and mRNA expression responses to periprandial changes and fasting–refeeding in Cyprinus carpio L. for the first time.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Apelin and apj in common carp ( Cyprinus carpio L.): Molecular characterization, tissue expression and responses to periprandial changes and fasting–refeeding

et al. 2020

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“…More recently, an improvement in glucose infusion rate and insulin sensitivity were also confirmed on apelin‐13 infusion to healthy overweight volunteers under euglycemic‐hyperinsulinemic clamp …”

Section: Introduction—the Apelinergic Systemmentioning

confidence: 72%

Apelins, ELABELA, and their derivatives: Peptidic regulators of the cardiovascular system and beyond

et al. 2018

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The apelinergic system emerges as an important regulator of cardiovascular functions via its actions on the heart, vasculature, and kidney. It also possesses additional beneficial properties, via its actions on the pancreas and skeletal muscle, on type 2 diabetes. The apelinergic system distinguishes itself by the presence of two structurally distinct sets of endogenous ligands, the Apelins (–13, −17, and −36) and Elabela, which both activate the apelin (APJ) receptor. In the past decade, numerous peptidic ligands have been used to better understand the structure–activity relationship of apelin (and more recently Elabela), providing important tools to rationalize how ligand modifications impact receptor structure and dynamics as well as its downstream signaling. The recently disclosed structure of the apelin receptor in complex with an analogue of apelin‐17 provides an important tool in this quest. In this review, we first summarize the physiopharmacology of the apelinergic system, then, review existing knowledge on the various ligands of the apelin receptor with an emphasis on peptidic ligands, although small molecules are covered as well. Throughout this work, we tried to integrate existing knowledge of ligands’ pharmacological profiles with structure and signaling profile.

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“…Two enzyme degradation‐resistant acylated analogs of apelin‐13 amide, (Lys 8 GluPAL)apelin‐13 amide and pGlu(Lys 8 GluPAL)apelin‐13 amide, were found to attenuate diabetic conditions, improve weight loss, and decrease circulating triglycerides and LDL cholesterol while increasing HDL cholesterol in high‐fat‐diet‐fed mice compared to saline control . A clinical trial on the influence of pyr1‐apelin‐13 (exopeptidase degradation resistant) on insulin sensitivity in healthy overweight men has been completed and shown to significantly improve insulin sensitivity in a hyperinsulinemic–euglycemic clamp study as well as cause no adverse effects due to apelin administration . A long circulating PEGylated variant of apelin‐36 was found to significantly lower blood glucose and improve glucose tolerance in diet‐induced obese mice …”

Section: Adipokines and Therapies That Modulate Their Activitymentioning

confidence: 99%

Remodeling adipose tissue inflammasome for type 2 diabetes mellitus treatment: Current perspective and translational strategies

Banerjee

Singh

2019

Bioengineering & Transla Med

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Obesity-associated type 2 diabetes mellitus (T2DM) is characterized by low-grade chronic systemic inflammation that arises primarily from the white adipose tissue. The interplay between various adipose tissue-derived chemokines drives insulin resistance in T2DM and has therefore become a subject of rigorous investigation. The adipocytokines strongly associated with glucose homeostasis include tumor necrosis factor-α, various interleukins, monocyte chemoattractant protein-1, adiponectin, and leptin, among others. Remodeling the adipose tissue inflammasome in obesity-associated T2DM is likely to treat the underlying cause of the disease and bring significant therapeutic benefit. Various strategies have been adopted or are being investigated to modulate the serum/tissue levels of pro-and anti-inflammatory adipocytokines to improve glucose homeostasis in T2DM. These include use of small molecule agonists/inhibitors, mimetics, antibodies, gene therapy, and other novel formulations. Here, we discuss adipocytokines that are strongly associated with insulin activity and therapies that are under investigation for modulation of their levels in the treatment of T2DM.

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Apelin administration improves insulin sensitivity in overweight men during hyperinsulinaemic‐euglycaemic clamp

Cited by 52 publications

References 20 publications

Apelin and apj in common carp ( Cyprinus carpio L.): Molecular characterization, tissue expression and responses to periprandial changes and fasting–refeeding

Apelin and apj in common carp ( Cyprinus carpio L.): Molecular characterization, tissue expression and responses to periprandial changes and fasting–refeeding

Apelins, ELABELA, and their derivatives: Peptidic regulators of the cardiovascular system and beyond

Remodeling adipose tissue inflammasome for type 2 diabetes mellitus treatment: Current perspective and translational strategies

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